SciELO - Scientific Electronic Library Online

 
vol.22 número1Factores de riesgo cardiovascular en pacientes con enfermedades reumáticasPrevalencia del síndrome de burnout en estudiantes de medicina índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Reumatología

versión On-line ISSN 1817-5996

Resumen

LEON FERNANDEZ, Olga Sonia et al. Gamma glutamyl transferase: an indicator of medical ozone clinical efficacy and its pathological role in rheumatoid arthritis and knee osteoarthritis. Rev Cuba Reumatol [online]. 2020, vol.22, n.1, e104.  Epub 17-Jun-2020. ISSN 1817-5996.

Introduction:

Medical ozone has demonstrated its clinical efficacy as well as the increase of beneficial/risk relationship in rheumatoid arthritis patients treated with metotrexate+ozone combined therapy. At present, gamma-glutamyl transpeptidase is considered as risk indicator of high morbimortality diseases. It has a special value in arthritis diseases due to its pathologic role associated to oxidative stress and in the abnormal bone remodeling processes.

Objective:

Assess the ozone medical effects on gamma-glutamyl transpeptidase levels.

Method:

Patients who suffered of two arthritic diseases: rheumatoid arthritis (n=100; Group treated with Metotrexate (n=50) and metotrexate+ozone (n=50) and knee osteoarthritis (n=40); Group preconditioned with ozone before arthroscopy (n=20) and Group without previous treatment with ozone before arthroscopy (n=20). Rheumatoid arthritis patients were assessed through specific clinic indicators which included antibodies against cyclic citrullinate peptides as well as reduced gluthatione concentrations which are an important endogenous antioxidant.

Results:

Medical ozone regulated serum gamma-glutamyl transpeptidase activity which correlated in inverse proportion to reduced glutathione levels which was the only one redox marker that correlated with all clinical variables (p < 0.05) when patients were treated with metotrexate+ozone.

Conclusion:

Gamma-glutamyl transpeptidase should be considered as biomarker of medical ozone clinical efficacy in rheumatoid arthritis and knee osteoarthritis due to GGT´s both pathologic functions: indicator of oxidative stress and abnormal bone remodeling processes.

Palabras clave : gamma-glutamyl transpeptidase; ozone; rheumatoid arthritis; knee osteoarthritis.

        · resumen en Español     · texto en Español     · Español ( pdf )