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Revista Cubana de Reumatología

versión On-line ISSN 1817-5996

Resumen

DE LEON OJEDA, Norma Elena et al. Platelet aggregation studies as an endophenotype of hereditary disorders of collagen fiber. Rev Cuba Reumatol [online]. 2020, vol.22, n.2, e782.  Epub 01-Ago-2020. ISSN 1817-5996.

Introduction:

Platelets contribute to hemostasis and inherited or acquired interruption; in its biochemical processes it can alter platelet function. These aggregation disorders have been associated with genetic diseases with connective tissue involvement such as Ehlers-Danlos syndrome, whose differential diagnosis with the spectrum of joint hypermobility is clinically and molecularly difficult. These entities with involvement of the collagen fibers and different clinical repercussions require differentials in their clinical diagnosis.

Methods:

353 medical records of patients attended in the Genetics service of the William Soler Pediatric Hospital from September 2009 to 2012, with a diagnosis of joint hypermobility by Beighton and Ehlers-Danlos criteria according to Villefranche (1997) were reviewed. Patients aged 5-18 years were included with documented results of the platelet aggregation study, assessed by specialists in hematology.

Results:

Platelet aggregation disorders were found in 79 of 86 patients (92%). In 7 cases with hypermobility of 65 with this diagnosis (10%), the results were negative. The 21 with Ehlers-Danlos syndrome had affectations with platelet phospholipids. Joint hypermobility was associated with the combination adenosine diphosphate (ADP) -epinephrine and the Ehlers-Danlos with the combination ADP-epinephrine-collagen-phospholipids.

Conclusions:

Patients with joint hypermobility showed an association to granule release defects with agonists such as ADP-epinephrine and Ehlers-Danlos with the availability of phospholipids, related to platelet shape change. This result can be a tool to know the platelet functional endophenotype as a differential element in collagen fiber disorders.

Palabras clave : platelet aggregation; endophenotype; collagen fiber; Ehlers-Danlos syndrome; joint hypermobility.

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