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Revista Finlay

versión On-line ISSN 2221-2434


PEREZ PONCE, Leonardo et al. Etiopathogenic Considerations of Alcohol in Pancreatitis. Rev. Finlay [online]. 2017, vol.7, n.1, pp.33-46. ISSN 2221-2434.

There is a close relation between alcohol intake and pancreas deleterious effects. Between 80 and 100 grams alcohol daily for more than three or 5 years may damage the pancreas and inflame it. This work was aimed at explaining the alcohol action mechanisms in the pancreas, so as describing the physiopathology of acute and chronic pancreatitis. For that, a total of 24 bibliographic sources were consulted, among them journal articles, books and others, accessed through the main information managers. It was concluded that the pancreas may brake down alcohol either via oxidative or non oxidative way, causing an increase of free radicals, pancreatic edema, intracellular trypsin activation, and the induction of proinflammatory transcription factors, which stimulate the stellate cells leading to a systemic inflammatory response and organic insufficiency.

Palabras clave : pancreatitis alcoholic; pancreatitis chronic.

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