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Revista Cubana de Química

versão On-line ISSN 2224-5421

Resumo

MARIN-SANCHEZ, Dayana et al. Chemical-analytic determination of Carbamazepine in antitoxic service. Presentation of case. Rev Cub Quim [online]. 2015, vol.27, n.3, pp.302-307. ISSN 2224-5421.

The drugs of narrow therapeutic margin constitutes one of the involuntary main causing chemical agents of exogenous intoxications type, one of the most common is the Carbamazepine. The clinical case describes a 7 years old male patient, which presented convulsions, hypotension, hypothermia and coma. At the admission moment in the hospital was considered the practice of the toxicological analytic chemical analysis for the causal agent's determination. The determination was carried out for the method of gas chromatography-mass spectrometry, in acids and basics urine extracts, for the confirmation of the diagnostic hypothesis. The results corroborated Carbamazepine as causal agent of intoxication, corresponding with the signs and clinical symptoms experienced by the patient. It a treatment with general measures of support was applied being reported a satisfactory clinical evolution.

Palavras-chave : carbamazepine; intoxication; GC-MS.

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