Resumo

ARRO-DIAZ, Diana Julia; CASTELNAUX-OCHOA, Naylan; OCHOA-PACHECO, Ania  e  DO-NASCIMENTO, Yuri Mangueira. Antioxidant activity of bioactive compounds isolated from leaves and bark of Gymnanthes lucida Sw. Rev Cub Quim [online]. 2021, vol.33, n.1, pp. 22-39.  Epub 10-Mar-2021. ISSN 2224-5421.

ABSTRACT Phytochemical investigations suggest that Gymnanthes lucida Sw. (aité) is a potential candidate for obtaining antioxidant principles. Total phenolic and flavonoid content were quantified and in vitro antioxidant capacity was assessed in extracts, ellagitannins, and coumarins isolated from the leaf and bark by three methods: 2,2-diphenyl-1-pricrylhydrazyl (DPPH) and 2,2´-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals scavenging activities and ferric reducing power. The highest phenolic and flavonoid content was observed in the leaf extract which also exhibited the highest activity among the extracts DPPH (IC50=12,82 ± 0,12 μg/mL), ABTS (IC50=13,83 ± 3,45 μg/mL), and reducing power (104% compared to ascorbic acid). Ellagic acid (EA) showed the highest activity, with DPPH (IC50=11,75 ± 0,53 μg/mL), ABTS (IC50=11,28 ± 0,28 μg/mL), and reducing power (107 % compared to ascorbic acid). Results suggest that G. lucida is a natural source of antioxidants where EA is the main secondary metabolite of the leaf responsible for the activity.

Palavras-chave : gymnanthes lucida Sw.; ellagitannins; coumarins; antioxidant activity.

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