Resumen

MONTES-GONZALEZ, Yanelys; HIDALGO-GUERRERO, Luis Carlos  y  MAYO-ABAD, Orestes. Sterilization of solutions for parenterals products. Problem analysis. RTQ [online]. 2017, vol.37, n.3, pp.367-379. ISSN 2224-6185.

The solutions for the formulation of parenteral products must be sterile before the aseptic formulation process. For this reason, different methods of sterilization referred in the literature are analyzed. Thermodynamic criteria that rule the sterilization are presented. Furthermore, previous experiences in the sterilization of solutions for the formulation of parental products in an autoclave are analyzed, that take large time of processing and only low volumes of solution can be handled. Using jacketed stirred tanks for the sterilization may solve the problem and, therefore, criteria for the design of the later that allow to process high volumes of solution for the formulation of parenteral products are shown.

Palabras clave : sterilization; jacketed tanks; parenterals products.

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