Resumen

BATISTA GARCIA-RAMO, Karla et al. Quantification of cerebral perfusion SPECT based on MRI co-registration and anatomic atlas. Rev cuba cienc informat [online]. 2022, vol.16, n.1, pp.113-127.  Epub 01-Mar-2022. ISSN 2227-1899.

The relative quantification of the regional cerebral blood flow by single-photon emission computed tomography presents different limitations related to the poor spatial resolution, the selection of the regions of interest and the selection of the reference region. The objective of the present work is to propose a methodology for the relative quantification of cerebral blood flow from the co-registration of functional and structural images and using anatomical atlases for the definition of regions. The methodology includes three main steps integrated into a pipeline in python: spatial pre-processing, partial volume correction, and calculation of the perfusion and asymmetry indexes. The methodology was implemented in 17 patients with epilepsy and 10 patients with Parkinson's disease. In patients with epilepsy, the results showed an increase in both perfusion and asymmetry index in the ictal study compared to the interictal one in the regions corresponding to the epileptogenic zone. In Parkinson's disease patients, regions with significant differences in both perfusion and asymmetry index were identified between patients at different stages. The methodology for the quantification of cerebral blood flow from single-photon emission computed tomography, magnetic resonance image and atlases is offered as a tool for pre-surgical evaluation of patients with epilepsy and for the evaluation of the neurodegenerative condition in Parkinson's disease.

Palabras clave : single-photon emission computed tomography; cerebral blood flow; quantification; epilepsy; Parkinson's disease.

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