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Vaccimonitor

versión impresa ISSN 1025-028Xversión On-line ISSN 1025-0298

Vaccimonitor v.15 n.3 Ciudad de la Habana sep.-dic. 2006

 

ARTICULOS DE REVISION

 

Papel de los anticuerpos en la protección contra micobacterium tuberculosis.

 

Role of antibodies in protecting against Micobacterium tuberculosis.

Nesty Olivares1, Ailín Vila1, Aniel Moya1, María Elena Sarmientos1, Armando Acosta1, Norazmi Mohd2

1. Instituto Finlay. Centro de Investigación – Producción de Vacunas. Ave.27 No. 19805. La Lisa.A.P.16017,C.P. 11600, Ciudad de La Habana.Cuba. Email:nolivares@finlay.edu.cu
2. School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.


RESUMEN

Convencionalmente se asume que la defensa del hospedero contra Mycobacterium tuberculosis se basa en los mecanismos de inmunidad celular exclusivamente y se descarta el papel de los anticuerpos en la protección. En este trabajo se analizan evidencias recientes que retan este dogma y sugieren la importancia de considerar la manipulación de la respuesta inmune humoral como una alternativa en la investigación de vacunas contra la tuberculosis.

Palabras claves: Tuberculosis, anticuerpos, vacunas.


ABSTRACT

Conventional thinking generally assumes that host defense mechanisms against Mycobacterium tuberculosis exclusively rely on cellular defense mechanisms and the role of antibodies in protecting against infection is ruled out. This work shows current evidences that change this dogma and suggest to consider the eliciting of the Humoral Immune Response as an alternative in vaccine research against Tuberculosis.

Keywords: Tuberculosis, Antibodies, Vaccines.


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