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Gaceta Médica Espirituana

On-line version ISSN 1608-8921

Gac Méd Espirit vol.22 no.2 Sancti Spíritus May.-Aug. 2020  Epub Aug 02, 2020



Incidence of non-alcoholic fatty liver disease

Conrado Ronaliet Alvarez Borges1  *

Ivianka Linares Batista2

1Policlínico Centro, Sancti Spíritus, Cuba.

2Hospital Provincial General Camilo Cienfuegos de Sancti Spíritus, Cuba.

Non-alcoholic fatty liver disease (NAFLD) is the infiltration of fat into the hepatocyte in the absence of alcohol consumption or other secondary chronic liver diseases; It includes a spectrum of liver conditions that ranges from simple steatosis to steatohepatitis, fibrosis and even cirrhosis, 1 appears in close relation with the metabolic syndrome and with it the increase in mortality from cardiovascular diseases and malignant diseases. NAFLD is slow but progressive in its evolution, so much so that it reaches advanced forms of liver damage in up to 30 % of cases in a period of 20 to 30 years. 2,3

Associated with the epidemic of obesity and diabetes mellitus, NAFLD has increased from 2.8 % to 46 %, also before 2010 it had already become 75 % of chronic liver diseases. 4 The incidence and worldwide prevalence of NAFLD is high globally and currently represents the most frequent chronic liver disease in western countries, with an estimated prevalence of 25 % in Europe in adults and it is estimated that approximately 25-30 % of these patients will progress to nonalcoholic steatohepatitis, representing an estimated prevalence of approximately 15 %. 5,6

In the general population of the countries of the western Asia it has been calculated between 20 % to 30 %; 1 it is estimated that in the United States the prevalence in the general population varies from 3 % to 23 %; in the Latino population the frequency of this disease evaluated by liver ultrasound was 15 % in Mexico and in Brazil among obese women 33 % 7. In Cuba, the actual prevalence of the disease is unknown; the data from the published studies of the disease come from postmortem studies or from research carried out in the general population using non-invasive diagnostic procedures. Non-alcoholic fatty liver disease (NAFLD) is a clinical condition that includes liver damage; it proceeds through different phases until it reaches cirrhosis (the final stage of the disease).

It is the hepatic response of the organism to the injury caused, its close relationship with other associated diseases makes it a health problem with repercussions both for the individual, the family and society. The asymptomatic or nonspecific presentation, apparently slow but progressive evolution of NAFLD, many times when it is diagnosed has already advanced. It appears with development and "new bad" lifestyles, it is frequently diagnosed at an early age; it is a disease whose evolutionary history and life span of these patients compared to liver disease caused by virus C, there are no differences between the two diseases; due to its relationship with hepatocarcinoma, it is considered the third most common indication for liver transplantation, simultaneously, there are currently no medications that reverse or prevent damage to the liver gland, so it is necessary to carry out research to find solutions that counter the fatty liver epidemic.


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2. Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology [Internet]. 2010 [cited 2018 Jan 15];51(1):121-9. Available from: Available from: ]

3. Suárez González M, López Mejia VM, Eirin Rey JM, González González EL, Medina Garrido Y, Díaz Oliva SE. Enfermedad hepática grasa no alcohólica. Algunas consideraciones diagnósticas. Acta Médica del Centro [Internet]. 2017 [citado 15 Ene 2019];11(2):10-8. Disponible en: Disponible en: ]

4. Cenetec-Salud. Guía de Práctica Clínica. Diagnóstico y Tratamiento de enfermedad hepática no alcohólica del adulto [Internet]. México: Cenetec-Salud; 2014. [citado 15 Ene 2019]. Disponible en: Disponible en: ]

5. Montes Teves P. Enfermedad por hígado graso no alcohólico: una epidemia en ascenso. Revista de gastroenterología del Perú [Internet]. 2016 Jul [citado 10 de Jul 2019];36(3):195-6. Disponible en: Disponible en: ]

6. Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, et al. Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States. Gastroenterology [Internet]. 2015 [cited 2019 Jan 15];148(3):547-55. Available from: Available from: ]

7. Sarmiento Quintero F, Botero V, D´Agostino D, Delgado Carbajal L, Dewaele Oliver MR, Guzmán C, et al. Enfermedad de hígado graso no alcohólico (EHGNA): revisión y puesta al día. Grupo de trabajo de la Sociedad Latinoamericana de Gastroenterología Hepatología y Nutrición Pediátrica (SLAGHNP). Acta Gastroenterol Latinoam [Internet]. 2016 [citado 15 Ene 2019];46(3):246-64. Disponible en: Disponible en: ]

Received: February 17, 2020; Accepted: April 07, 2020

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