<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0138-6557</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Militar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Med Mil]]></abbrev-journal-title>
<issn>0138-6557</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0138-65572021000400003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación de los niveles séricos de ácido úrico, con la mortalidad y morbilidad en pacientes graves con ventilación mecánica]]></article-title>
<article-title xml:lang="en"><![CDATA[Relationship of serum uric acid levels with mortality and morbidity in critically ill patients with mechanical ventilation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Pedroso]]></surname>
<given-names><![CDATA[Wilfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Alejo]]></surname>
<given-names><![CDATA[José Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chacón Montano]]></surname>
<given-names><![CDATA[Deyli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
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<contrib contrib-type="author">
<name>
<surname><![CDATA[Rittoles Navarro]]></surname>
<given-names><![CDATA[Aliusha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[Leticia del Rosario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chibás Ponce]]></surname>
<given-names><![CDATA[Efraín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Militar Central "Dr. Luís Díaz Soto"  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>50</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0138-65572021000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0138-65572021000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0138-65572021000400003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Los procesos oxidativos en el paciente clínico grave con ventilación mecánica, justifican investigar la posible asociación de los niveles del ácido úrico sérico, con la mortalidad y morbilidad.  Objetivo:  Identificar la posible asociación del ácido úrico sérico al ingreso, con la mortalidad y morbilidad de pacientes clínicos graves, con ventilación mecánica invasiva.  Métodos:  Se realizó estudio descriptivo longitudinal y prospectivo, en 89 pacientes clínicos graves con ventilación mecánica, ingresados en cuidados intensivos del hospital &#8220;Dr. Luís Díaz Soto&#8221; de enero del 2000 a agosto del 2007. Al ingreso y por 72 horas se determinó el ácido úrico sérico, cuyo valor medio se contrastó con la mortalidad, la morbilidad y el tiempo de ventilación mecánica. Las variables cuantitativas se expresaron como media con una desviación estándar; las cualitativas, como frecuencias absolutas o porcentajes. La comparación de medias se realizó con la t de Student. La asociación entre variables cualitativas se evaluó con el ji cuadrado.  Resultados: Predominó el sexo masculino (58,4 %), edad media de 51,2 años y como mayor diagnóstico al ingreso, la sepsis (47,1 %). Se asociaron los valores elevados del ácido úrico a la mortalidad hospitalaria, la presencia del síndrome de daño múltiple de órganos (316,8 ± 165 mmol/L, p = 0,04) y al mayor tiempo de ventilación mecánica (307,3 ± 157 mmol/L, p = 0,016).  Conclusiones: La asociación del ácido úrico sérico con la mortalidad y morbilidad, es evidente, en pacientes con afecciones clínicas graves y ventilación mecánica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: The oxidative process in severe clinically ill patient with mechanical ventilation, base the possible association of serum uric acid with mortality and morbidity.  Objectives:  To identify the possible association of serum uric acid with the mortality and morbidity of severe clinically ill patients with invasive mechanical ventilation.  Methods: A longitudinal and prospective observational study was carried out in 89 patients with invasive mechanical ventilation, admitted to the intensive care unit of the Hospital &#8220;Dr. Luís Díaz Soto&#8221;, from January 2000 to August 2007. On admission and for three consecutive days, the serum uric acid was determined with a Hitachi 902 microprocessor. The mean value was contrasted with mortality, morbidity, and mechanical ventilation time. Quantitative variables were expressed as mean and standard deviation; the comparison of means was made with Student&#8217;s t test. Qualitative variables were expressed with absolute frequencies and percentages; the association was evaluated with the chi square.  Results: Male sex predominated (58,4 %) and mean age of 51,2 ± 14,9 years. The most frequent diagnosis on admission was sepsis (47,1 %). The mortality was 59,6 % and 66,3% in the hospital. The higher value of uric acid was associated to hospital mortality, the multiple organ damage syndrome (316,8 ± 165 mmol/l p=0,04) and the longer mechanical ventilation time (307,3 ± 157 mmol/l p=0,016).  Conclusions:  The association of mortality and morbidity, with serum uric acid on admission, was evident in severe clinical patients with mechanical ventilation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácido úrico]]></kwd>
<kwd lng="es"><![CDATA[ventilación mecánica invasiva]]></kwd>
<kwd lng="es"><![CDATA[cuidados intensivos]]></kwd>
<kwd lng="en"><![CDATA[uric acid]]></kwd>
<kwd lng="en"><![CDATA[critical care]]></kwd>
<kwd lng="en"><![CDATA[severe surgical patients]]></kwd>
<kwd lng="en"><![CDATA[mechanical ventilation]]></kwd>
</kwd-group>
</article-meta>
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