<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002020000100021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actividad biológica y toxicológica de los ácidos biliares en la actualidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Biological and toxicological activity of bile acids today]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piñol Jiménez]]></surname>
<given-names><![CDATA[Felipe Neri]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Torres]]></surname>
<given-names><![CDATA[Julián Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Segura Fernández]]></surname>
<given-names><![CDATA[Nilmer]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Proaño Toapanta]]></surname>
<given-names><![CDATA[Pedro Segundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Figueroa]]></surname>
<given-names><![CDATA[Eder Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Cirugía de Mínimo Acceso  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,GastroSalud  ]]></institution>
<addr-line><![CDATA[Chiclayo ]]></addr-line>
<country>Perú</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital General San Vicente de Paúl de Ibarra  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Mexicano de Cirugía Endoscópica Hospital General de Zona # 67 ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>39</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002020000100021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002020000100021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002020000100021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: los ácidos biliares no solo tienen como actividad biológica regular la absorción de vitaminas liposolubles, colesterol y lípidos, sino actúan también como moléculas de señalización, moduladores de la proliferación celular intestinal, de la expresión de genes y del metabolismo energético según estudios in vitro e in vivo; en condiciones fisiológicas mantienen su homeostasis, que al ser interrumpida promueve suacción toxicológica.  Objetivo: describir la actualidad de los nuevos conocimientos sobre la actividad biológica y toxicológica de los ácidos biliares en el aparato digestivo, dirigido a cirujanos generales, gastroenterólogos, clínicos y fisiólogos que les permitan contextualizar el proceso inflamación-carcinogénesis relacionado con los efectos toxicológicos de los ácidos biliares.  Método: se realizó una revisión sistemática de la actividad biológica y toxicológica de los ácidos biliares para los cirujanos generales, gastroenterólogos, clínicos y fisiólogos, como herramienta útil en la compresión fisiopatológico del metabolismo de los ácidos biliares.  Conclusión: los ácidos biliares desempeñan una función clave como moléculas de señalización en la modulación de la proliferación de células epiteliales, la expresión de genes y el metabolismo energético, que cuando se interrumpe su homeostasis se promueve la acción tóxica de estos, lo que se traduce en el proceso inflamación-carcinogénesis digestiva.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  bile acids not only have as a regular biological activity the absorption of fat-soluble vitamins, cholesterol and lipids, but also act as signaling molecules, modulators of intestinal cell proliferation, gene expression and energy metabolism according to in vitro studies and in vivo; under physiological conditions they maintain their homeostasis, which when interrupted promotes their toxicological action.  Objective:  to describe the news of the new knowledge about the biological and toxicological activity of bile acids in the digestive system, aimed at general surgeons, gastroenterologists, clinicians and physiologists that allow them to contextualize the inflammation-carcinogenesis process related to the toxicological effects of bile acids. Method: A systematic review of the biological and toxicological activity of bile acids was performed for general surgeons, gastroenterologists, clinicians and physiologists, as a useful tool in the pathophysiological compression of bile acid metabolism.  Conclusion:  bile acids play a key role as signaling molecules in the modulation of epithelial cell proliferation, gene expression and energy metabolism, which when their homeostasis is interrupted, their toxic action is promoted, which translates in the inflammation-digestive carcinogenesis process.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácidos biliares]]></kwd>
<kwd lng="es"><![CDATA[actividad biológica]]></kwd>
<kwd lng="es"><![CDATA[toxicología]]></kwd>
<kwd lng="en"><![CDATA[biliary acids]]></kwd>
<kwd lng="en"><![CDATA[biological activity]]></kwd>
<kwd lng="en"><![CDATA[toxicology]]></kwd>
</kwd-group>
</article-meta>
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