<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-084X</journal-id>
<journal-title><![CDATA[Nucleus]]></journal-title>
<abbrev-journal-title><![CDATA[Nucleus]]></abbrev-journal-title>
<issn>0864-084X</issn>
<publisher>
<publisher-name><![CDATA[CUBAENERGIA]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-084X2019000100023</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The modeling of the reaction cross sections in the production of teranositic radionuclides]]></article-title>
<article-title xml:lang="es"><![CDATA[La modelación de las secciones eficaces de reacción en la producción de radionúclidos teranosíticos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fontana]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pupillo]]></surname>
<given-names><![CDATA[Gaia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mou]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rossi Alvarez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Esposito]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Canton]]></surname>
<given-names><![CDATA[Luciano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Pavia (PV) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Italy</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Istituto Nazionale di Fisica Nucleare (INFN) Laboratori Nazionali di Legnaro (LNL) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Italy</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Padova (PD) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Italy</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<numero>65</numero>
<fpage>23</fpage>
<lpage>27</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-084X2019000100023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-084X2019000100023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-084X2019000100023&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract We utilize various nuclear reaction codes with the aim to guide, interpret, and support the experiments in the proton-induced production measurements of radionuclides for the development of innovative radio-pharmaceuticals. The understanding of reaction cross sections at low-intermediate energies is crucial in this context and requires the knowledge of nuclear models available in different codes, such as EMPIRE, TALYS, and FLUKA. These nuclear reaction codes serve as tool to interpret the measurement of production cross-sections and to complete the measurements with estimates of production of contaminants and/or stable isotopes that are difficult to measure. We illustrate different model calculations to simulate isotope production useful in experiments devoted to the measurement of proton-induced production of the two theranostic radio-isotopes 67Cu and 47Sc.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Utilizamos varios códigos de reacción nuclear con el objetivo de guiar, interpretar y respaldar los experimentos en las mediciones de producción de radionúclidos inducidas por protones para el desarrollo de productos radio-farmacéuticos innovadores. La comprensión de las secciones eficaces de reacción en energías intermedias bajas es crucial en este contexto y requiere el conocimiento de modelos nucleares disponibles en diferentes códigos, como EMPIRE, TALYS y FLUKA. Estos códigos de reacción nuclear sirven como herramienta para interpretar la medición de secciones eficaces de producción y para completar las mediciones con estimaciones de producción de contaminantes y / o isótopos estables que son difíciles de medir. Ilustramos diferentes cálculos de modelos para simular la producción de isótopos útiles en experimentos dedicados a la medición de la producción inducida por protones de los dos isótopos teranósticos 67Cu y 47Sc.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[nuclear reactions]]></kwd>
<kwd lng="en"><![CDATA[isotope production]]></kwd>
<kwd lng="en"><![CDATA[copper 67]]></kwd>
<kwd lng="en"><![CDATA[scandium 47]]></kwd>
<kwd lng="en"><![CDATA[cross sections]]></kwd>
<kwd lng="en"><![CDATA[simulation]]></kwd>
<kwd lng="es"><![CDATA[reacciones nucleares]]></kwd>
<kwd lng="es"><![CDATA[producción de isotopos]]></kwd>
<kwd lng="es"><![CDATA[cobre 67]]></kwd>
<kwd lng="es"><![CDATA[escandio 47]]></kwd>
<kwd lng="es"><![CDATA[secciones eficaces]]></kwd>
<kwd lng="es"><![CDATA[simulación]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>[1]</label><nlm-citation citation-type="book">
<collab>IAEA</collab>
<source><![CDATA[Cyclotron produced radionuclides: physical characteristics and production methods]]></source>
<year>2009</year>
<publisher-loc><![CDATA[Vienna ]]></publisher-loc>
<publisher-name><![CDATA[IAEA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>[2]</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[JALILIAN]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<source><![CDATA[IAEA. Therapeutic radiopharmaceuticals labelled with new emerging radionuclides (67Cu, 186Re, 47Sc)]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Vienna ]]></publisher-loc>
<publisher-name><![CDATA[IAEA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>[3]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[NOVAK-HOFER]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[SCHUBINGER]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Copper-67 as a therapeutic nuclide for radioimmunotheraphy]]></article-title>
<source><![CDATA[Eur J Nucl Med]]></source>
<year>2002</year>
<numero>29</numero>
<issue>29</issue>
<page-range>821-30</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>[4]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MAUSNER]]></surname>
<given-names><![CDATA[LF]]></given-names>
</name>
<name>
<surname><![CDATA[KOLSKY]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[JOSHI]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[SRIVASTAVA]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Radionuclide development at BNL for nuclear medicine therapy]]></article-title>
<source><![CDATA[Appl Radiat Isot]]></source>
<year>1998</year>
<numero>49</numero>
<issue>49</issue>
<page-range>285-94</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>[5]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[PUPILLO]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[SOUNALET]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[MICHEL]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[MOU]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New production cross section for the theranostic radionuclide 67Cu]]></article-title>
<source><![CDATA[Nuclear Inst. and Methods in Physics Research B]]></source>
<year>2018</year>
<numero>415</numero>
<issue>415</issue>
<page-range>41-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>[6]</label><nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[KONING]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[HILARIE]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[DUIJVESTIJN]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<source><![CDATA[TALYS-1.0]]></source>
<year>2007</year>
<conf-name><![CDATA[ Proceedings of the International Conference on Nuclear Data for Science and Technology]]></conf-name>
<conf-loc> </conf-loc>
<page-range>211-4</page-range><publisher-loc><![CDATA[Nice, France ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B7">
<label>[7]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HERMAN]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[CAPOTE]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[CARLSON]]></surname>
<given-names><![CDATA[BV]]></given-names>
</name>
<name>
<surname><![CDATA[OBLOZINSKY]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[EMPIRE: nuclear reaction model code system for data evaluation]]></article-title>
<source><![CDATA[Nucl. Data Sheets]]></source>
<year>2007</year>
<numero>108</numero>
<issue>108</issue>
<page-range>2655-715</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>[8]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BOEHLEN]]></surname>
<given-names><![CDATA[TT]]></given-names>
</name>
<name>
<surname><![CDATA[CERUTTI]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[CHIN]]></surname>
<given-names><![CDATA[MPW]]></given-names>
</name>
<name>
<surname><![CDATA[FASSO&#8217;]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The FLUKA code: developments and challenges for high energy and medical applications]]></article-title>
<source><![CDATA[Nucl. Data Sheets]]></source>
<year>2014</year>
<numero>120</numero>
<issue>120</issue>
<page-range>211-4</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>[9]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[INFANTINO]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[OEHLKE]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[MOSTACCIA]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[SCHAFFER]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: simulations against experimental measurements]]></article-title>
<source><![CDATA[Nuclear Inst. and Methods in Physics Research B]]></source>
<year>2016</year>
<volume>366</volume>
<page-range>117-23</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>[10]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DUCHEMIN]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[GUERTIN]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[HADDAD]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[MICHEL]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of medical isotopes from a thorium target irradiated by light charged particles up to 70 MeV]]></article-title>
<source><![CDATA[Phys Med Biol]]></source>
<year>2015</year>
<volume>60</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>931-46</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>[11]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GORIELY]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[HILAIRE]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[KONING]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Improved microscopic nuclear level densities within the Hartree-Fock-Bogoliubov plus combinatorial method]]></article-title>
<source><![CDATA[Phys. Rev. C]]></source>
<year>2008</year>
<volume>78</volume>
</nlm-citation>
</ref>
<ref id="B12">
<label>[12]</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DITRÒI]]></surname>
</name>
<name>
<surname><![CDATA[TARKANYI]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[TAKACS]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[HERMANNE]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Activation cross-sections of proton induced reactions on vanadium in the 37-65 MeV energy range]]></article-title>
<source><![CDATA[Nuclear Inst. and Methods in Physics Research B]]></source>
<year>2016</year>
<volume>381</volume>
<page-range>16-28</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
