<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[AMC]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552018000400417</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores atópicos asociados a la sibilancia recurrente en el menor de cinco años]]></article-title>
<article-title xml:lang="en"><![CDATA[Atopic risk factors for recurrent wheeze in children under five years old]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coronel Carvajal]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Hospital General Universitario Armando Cardoso de Guáimaro ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>417</fpage>
<lpage>431</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552018000400417&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552018000400417&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552018000400417&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  la sibilancia recurrente es la presencia de tres o más episodios de sibilancias y constituye la forma de presentación más frecuente del asma en el menor de cinco años.  Objetivo:  determinar los factores atópicos asociados a la sibilancia recurrente en el menor de cinco años.  Métodos:  se realizó un estudio de casos y controles en Guáimaro provincia de Camagüey, desde junio de 2015 hasta enero de 2017. Los casos fueron 114 niños menores de cinco años con sibilancias recurrentes e igual cantidad de niños sin este diagnóstico conformaron los controles. La información se obtuvo mediante un cuestionario a los padres.  Resultados:  el diagnóstico de dermatitis atópica (OR=6, 1. IC95%3,5-10,3), antecedentes atópicos en madre o padre (OR=3,7IC95%2,5-5,4), alergia alimentaria (OR 3,6IC95%2,2-5,9), estigmas atópicos cutáneos (OR 2,9 IC95%1,8-4,1), eosinofilia&gt; 4 % (OR=2,8IC95%1,8-4,1) y la marcha alérgica (OR=8,4IC95%4,7-14,3) mostraron asociación de estadística significativa con la sibilancia recurrente. La presencia de dos factores atópicos elevó el riesgo en ocho veces para la sibilancia recurrente OR=8,3 (IC95%5,4-12,2), tres a cuatro lo elevaron en más de 12 veces OR=12,2 (IC95%7,6-19,2) y cinco o más incrementaron el riesgo en casi 20 veces OR=19,8 (IC95%10,5-36,8).  Conclusiones:  fueron factores de riesgo para la sibilancia recurrente: el diagnóstico de dermatitis atópica, la historia de familiares de atópicos, la alergia alimentaria, la presencia de estigmas atópicos cutáneos, la eosinofilia mayor de 4 % y la marcha atópica. El riesgo de sibilancia recurrente aumentó en proporción con el número de factores atópicos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  the recurrent wheeze is the presence of the three or more episodes of wheeze and is the main manifestation of asthma in children under five years old.  Objective:  to determine the atopic factors associated with recurrent wheeze in children less than five years.  Methods:  a case-control study was made in Guáimaro, Camagüey province, Cuba from June 2015 to January 2017. The cases were 114 children under five years old with diagnostic of recurrent wheeze and the same number of children without diagnostic of recurrent wheeze were the controls. The information was obtained through a questionnaire applied to parents of children.  Results:  the diagnosis of allergic dermatitis (OR=6,1, IC95%3,5-10,3), history of atopic disease in mother o father (OR=3,7IC95% 2,5-5,4), food allergy (OR 3,6IC95% 2,2-5,9), cutaneous atopic stigma (OR 2,9 IC95% 1,8-4,1), eosinophilia &gt; 4 % (OR=2,8IC95%1,8-4,1) and allergic march (OR=8,4IC95% 4,7-14,3) showed significant associations with recurrent wheeze. The presence of two atopic factors increased in 8 times the risk of recurrent wheeze (OR=8,3; IC95% 5,4-12,2), three to four factors elevated the possibility in more than 12 times (OR=12,2; IC95% 7,6-19,2) and five o- more increased the risk almost 20 times (OR=19,8; IC95% 10,5-36,8).  Conclusions:  the risk factors for recurrent wheeze were the diagnosis of allergic dermatitis, family history of atopic disease, food allergy, cutaneous atopic stigma, eosinophilia higher than 4% and allergic march. The risk of recurrent wheeze increased proportionally to the number of the atopic factors.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[RUIDOS RESPIRATORIOS]]></kwd>
<kwd lng="es"><![CDATA[RISK FACTORS]]></kwd>
<kwd lng="es"><![CDATA[DERMATITIS ATÓPICA]]></kwd>
<kwd lng="es"><![CDATA[PREESCOLAR]]></kwd>
<kwd lng="es"><![CDATA[ESTUDIOS DE CASOS Y CONTROLES]]></kwd>
<kwd lng="en"><![CDATA[RESPIRATORY SOUNDS]]></kwd>
<kwd lng="en"><![CDATA[RISK FACTORS]]></kwd>
<kwd lng="en"><![CDATA[DERMATITIS, ATOPIC]]></kwd>
<kwd lng="en"><![CDATA[CHILD, PRESCHOOL]]></kwd>
<kwd lng="en"><![CDATA[CASE-CONTROL STUDIES]]></kwd>
</kwd-group>
</article-meta>
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