<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942021000600016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alternativa de tratamiento con células madre en pacientes con colitis ulcerosa]]></article-title>
<article-title xml:lang="en"><![CDATA[Alternative stem cell therapy in patients with ulcerative colitis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Francés-Acosta]]></surname>
<given-names><![CDATA[Yantiel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-López]]></surname>
<given-names><![CDATA[Medardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Ruiz]]></surname>
<given-names><![CDATA[Adisnubia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pimienta-Lorenzo]]></surname>
<given-names><![CDATA[Abel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mayor-Porras]]></surname>
<given-names><![CDATA[Aymee]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Hospital General Docente Abel Santamaría Cuadrado ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942021000600016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942021000600016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942021000600016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la colitis ulcerosa es una enfermedad crónica, inflamatoria, ulcerosa y recidivante del tracto gastrointestinal, que evoluciona por recaídas.  Objetivo:  determinar la efectividad del tratamiento alternativo con células madre en los paciente con diagnóstico de colitis ulcerosa, en el Hospital &#8220;Abel Santamaría Cuadrado &#8220;de Pinar del Río en período del 2018-2020.  Métodos:  se realizó un estudio descriptivo, longitudinal y prospectivo. El universo estuvo constituido por 425 pacientes y la muestra quedó conformada por 135 pacientes con diagnóstico de colitis ulcerosa que cumplieron con los criterios de inclusión. Se revisaron las historias clínicas individuales.  Resultados:  predominó el grupo de edades de 45-54 años (44 %) y el sexo femenino (59,25 %). Predominaron los malos hábitos dietéticos (65,1 %); la ingestión de medicamentos (40 %) y el tabaquismo (32,5 %); además de los antecedentes patológicos familiares de colitis ulcerosa (48,1 %). Predominaron las deposiciones mucosanguinolentas (65,1 %), la rectorragia (48,1 %) y el dolor abdominal (23,7 %); así como el método endoscópico (69,6 %). Se constató una evolución satisfactoria (93,5 %) con la aplicación de la terapia celular.  Conclusiones:  el sexo femenino y el grupo de edades entre 45 - 54 años fueron los predominantes. Los factores de riesgo predominantes fueron, los malos hábitos dietéticos y la ingestión de medicamentos. Preponderó la colitis ulcerosa como antecedente patológico familiar. Las deposiciones mucosanguinolentas, la rectorragia, y el dolor abdominal, fueron los síntomas más relevantes. El procedimiento endoscópico constituyó el método más importante y quedó demostrada la efectividad del método alternativo con células madre autólogas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ ABSTRACT  Introduction: ulcerative colitis is a chronic, inflammatory, ulcerative and relapsing disease of the gastrointestinal tract, which evolves by relapses.  Objective: to determine the effectiveness of alternative treatment with stem cells in patients diagnosed with ulcerative colitis at Abel Santamaria Cuadrado General Teaching Hospital, Pinar del Rio province in the period of 2018-2020.  Methods: a descriptive, longitudinal and prospective study was conducted. The target group consisted of 425 patients and the sample comprised 135 patients with a diagnosis of ulcerative colitis who met the inclusion criteria. Individual medical records were reviewed.  Results: the age group 45-54 years (44 %) and female sex (59,25 %) predominated. Poor dietary habits (65,1 %), medication intake (40 %) and smoking (32,5 %) predominated, as well as a family history of ulcerative colitis (48.1 %). Mucous bloody stools (65,1 %), rectorrhagia (48,1 %) and abdominal pain (23,7 %) predominated, as well as the endoscopic method (69,6 %). A satisfactory evolution (93,5 %) was observed with the application of stem cell therapy.  Conclusions: female sex and the age group 45-54 years were predominant. The main risk factors were poor dietary habits and medication intake. Ulcerative colitis predominated as a family pathological history. Mucous bloody stools, rectorrhagia and abdominal pain were the most relevant symptoms. The endoscopic procedure was the most important method and the effectiveness of the alternative method with autologous stem cells was demonstrated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CÉLULAS MADRE]]></kwd>
<kwd lng="es"><![CDATA[COLITIS ULCEROSA]]></kwd>
<kwd lng="es"><![CDATA[TERAPIA CELULAR]]></kwd>
<kwd lng="en"><![CDATA[STEM CELLS]]></kwd>
<kwd lng="en"><![CDATA[COLITIS, ULCERATIVE]]></kwd>
<kwd lng="en"><![CDATA[IMMUNOTHERAPY, ADOPTIVE]]></kwd>
</kwd-group>
</article-meta>
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