<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-897X</journal-id>
<journal-title><![CDATA[MediSur]]></journal-title>
<abbrev-journal-title><![CDATA[Medisur]]></abbrev-journal-title>
<issn>1727-897X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas, Provincia de Cienfuegos.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-897X2020000100050</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alteraciones funcionales ventilatorias en pacientes adultos con drepanocitosis]]></article-title>
<article-title xml:lang="en"><![CDATA[Functional ventilatory alterations in adult patients with sickle cell disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña Batista]]></surname>
<given-names><![CDATA[Andrés Pavel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sierra Martínez]]></surname>
<given-names><![CDATA[Dianelis Perla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Águila]]></surname>
<given-names><![CDATA[Julio Dámaso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabrera Zamora]]></surname>
<given-names><![CDATA[Maritza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pino Blanco]]></surname>
<given-names><![CDATA[Reinaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Villares]]></surname>
<given-names><![CDATA[Flora]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Universitario Dr. Gustavo Aldereguía Lima  ]]></institution>
<addr-line><![CDATA[Cienfuegos Cienfuegos]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Cienfuegos  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<volume>18</volume>
<numero>1</numero>
<fpage>50</fpage>
<lpage>57</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-897X2020000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-897X2020000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-897X2020000100050&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  en los pacientes con drepanocitosis las alteraciones de la función pulmonar son frecuentes y pueden detectarse por la espirometría.  Objetivo:  describir las alteraciones de la función ventilatoria en los pacientes con drepanocitosis seguidos en consulta provincial de hemoglobinopatías.  Métodos:  estudio observacional, descriptivo, de corte transversal. Se incluyeron 76 pacientes, seleccionados por muestreo no probabilístico accidental, de 88 adultos seguidos en el Hospital Dr. Gustavo Aldereguía Lima. Las variables estudiadas fueron: edad, sexo, tipo de hemoglobinopatía, síntomas respiratorios, antecedentes de síndrome torácico agudo, (formas clínicas y número de eventos), comorbilidades y patrón ventilatorio. Las pruebas funcionales ventilatorias se realizaron con Microspiro digital Hellige.  Resultados:  el grupo de edad entre 20-29 años fue el más frecuente (34,2 %). Hubo discreto predominio del sexo femenino (56,1 %) y del genotipo SS (67,1 %). El más frecuente de los síntomas respiratorios fue la disnea y entre las comorbilidades la insuficiencia cardíaca en 9,2 % de los enfermos. En 42,1 % se registró antecedentes de síndrome torácico agudo, neumonía en la mayoría de los casos. Nueve enfermos (11,8 %) presentaron trastornos obstructivos y 43 enfermos (56,6 %) un patrón restrictivo.En el genotipo SS el riesgo de tener alteraciones en la espirometría resultó tres veces mayor que el resto [OR=3,2 IC (1,7-5,9)]  Conclusiones:  resultó común el hallazgo de prueba funcional ventilatoria alterada con predominio del patrón restrictivo. Estas modificaciones se observaron con mayor frecuencia en pacientes con el genotipo SS.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Foundation:  in patients with sickle cell disease, lung function abnormalities are frequent and can be detected by spirometry.  Objective:  to describe the disturbances of the respiratory functions in patients with sickle cell disease followed in a provincial consultation of hemoglobinopathies.  Methods:  observational, descriptive, cross-sectional study. Seventy six patients, selected by accidental non-probabilistic sampling, of 88 adults followed at the Dr. Gustavo Aldereguía Lima Hospital were included. The variables studied were: age, sex, type of hemoglobinopathy, respiratory symptoms, history of acute thoracic syndrome, (clinical forms and number of events), comorbidities and ventilatory pattern. Functional ventilatory tests were performed with Hellige digital Microspiro.  Results:  the age group between 20-29 years was the most frequent (34.2%). There was a discrete female predominance (56.1%) and the SS genotype (67.1%). The most frequent of the respiratory symptoms was dyspnea and among the comorbidities heart failure in 9.2% of the patients. In 42.1% there was a history of acute chest syndrome, pneumonia in most cases. Nine patients (11.8%) presented obstructive disorders and 43 patients (56.6%) a restrictive pattern. In the SS genotype the risk of having spirometry alterations was three times higher than the rest [OR = 3.2 IC (1.7-5.9)]  Conclusion:  the finding of altered respiratory functional test with a predominance of the restrictive pattern was common. These modifications were observed more frequently in patients with the SS genotype.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[anemia de células falciformes]]></kwd>
<kwd lng="es"><![CDATA[ventilación pulmonar]]></kwd>
<kwd lng="es"><![CDATA[espirometría]]></kwd>
<kwd lng="en"><![CDATA[anemia]]></kwd>
<kwd lng="en"><![CDATA[sickle cell]]></kwd>
<kwd lng="en"><![CDATA[respiration]]></kwd>
<kwd lng="en"><![CDATA[spirometry]]></kwd>
</kwd-group>
</article-meta>
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