<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2442</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Químicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Quím.]]></abbrev-journal-title>
<issn>2221-2442</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24422023000100027</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[SÍNTESIS DE NANOHIDROXIAPATITA DOPADA CON IONES ESTRONCIO: INFLUENCIA DEL sr2+ EN LAS PROPIEDADES ESTRUCTURALES DE LAS NANOPARTÍCULAS Y DE BIOMATERIALES CERÁMICOS MICROPOROSOS]]></article-title>
<article-title xml:lang="en"><![CDATA[SYNTHESIS OF NANOHYDROXIAPATITE DOPED WITH STRONTIUM IONS: INFLUENCE OF sr2+ ON THE STRUCTURAL PROPERTIES OF NANOPARTICLES AND MICROPOROUS CERAMIC BIOMATERIALS]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morejón Alonso]]></surname>
<given-names><![CDATA[Lizette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermúdez Pérez]]></surname>
<given-names><![CDATA[Sheyla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado García-Menocal]]></surname>
<given-names><![CDATA[José Angel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendizábal Mijares]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Biomateriales (BIOMAT)  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Estudios Avanzados de Cuba (CEA)  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Internacional de Catalunya (UIC)  ]]></institution>
<addr-line><![CDATA[ Barcelona]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI, UdG)  ]]></institution>
<addr-line><![CDATA[ Guadalajara]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>54</volume>
<fpage>27</fpage>
<lpage>43</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24422023000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24422023000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24422023000100027&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En la actualidad la hidroxiapatita funcionalizada con iones (HA-X) permite el desarrollo de nuevas propuestas de implantes biomédicos con mayor similitud a la hidroxiapatita natural, algunos de estos iones incentivan procesos biológicos para la osteointegración temprana de los implantes. En particular, el dopaje con Sr2+ resulta de interés por el papel dual conocido de este ion de incidir en el metabolismo óseo favoreciendo la osteosíntesis y a la vez limitando la osteoclastia. Este trabajo evalúa la efectividad de la síntesis por vía húmeda acoplada a ultrasonido para la obtención de HA-Sr con 0, 10, 20% molar de substitución del ion Ca2+. Las partículas se caracterizaron por Espectroscopia Infrarroja, Difracción de Rayos-X, Espectroscopia Fotoelectrónica de Rayos-X y Dispersión de Luz Dinámica. Se prepararon cerámicas a partir de las apatitas sintetizadas por sinterización a 900 °C/6 h, las cuales se analizaron por Microscopía Electrónica de Barrido y se estudió su bioactividad in vitro por inmersión en solución de Fluido Fisiológico Simulado. Los resultados obtenidos indicaron buena eficacia de la metodología utilizada en la obtención de las HA-Sr. Se detectó que las partículas resultaron nanométricas, que con la incorporación de Sr2+ los tamaños de cristalito disminuyen desde ~50nm a ~30nm, la fracción de cristalinidad disminuye casi en un 80% (desde 74,3% a 12,5%), mientras incrementó el volumen de la celda unidad. La presencia de Sr2+ en la hidroxiapatita aumentó significativamente la contracción de las piezas cerámicas por lo cual disminuyó su porosidad total. A la vez, aumentó el tamaño de los granos cerámicos, disminuyó las dimensiones de poros e hizo estrecha sus distribuciones. Se demostró que la presencia de Sr2+ acelera la bioactividad de las cerámicas lo que hace a estas cerámicas apropiadas para su interacción con el tejido óseo vivo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT At present, ion-functionalized hydroxyapatite (HA-X) allows the development of new proposals for biomedical implants with greater similarity to natural hydroxyapatite, while some of these ions encourage biological processes for early implant osseointegration. In particular, doping with Sr2+ is very interesting due to the known dual role of this ion of influencing bone metabolism, favoring osteosynthesis and, at the same time, limiting osteoclasty. This work evaluates the effectiveness of the wet synthesis coupled to ultrasound to obtain HA-Sr with 0, 10, 20% molar substitution of the Ca2+ ion. The particles were characterized by Infrared Spectroscopy, X-Ray Diffraction, X-Ray Photoelectron Spectroscopy and Dynamic Light Scattering. Ceramics were prepared from the synthesized apatites by sintering at 900 °C/6 h, which were analyzed by Scanning Electron Microscopy and their in vitro bioactivity was studied by immersion in Simulated Body Fluid solution. The results obtained indicated good efficacy of the methodology used to obtain the HA-Sr. It was detected that particles were nanometric, that with the incorporation of Sr2+ the crystallite sizes decrease from ~50nm to ~30nm, the crystallinity fraction decreases by almost 80% (from 74.3% to 12.5%), while the volume of the unit cell increased. The presence of Sr2+ in the hydroxyapatite significantly increased the shrinkage of the ceramic pieces and decreased their total porosity. At the same time, it increased the size of the ceramic grains, decreased the dimensions of the pores and narrowed their distributions. It was also shown that the presence of Sr2+ accelerates the bioactivity of ceramics, making them suitable for interaction with the living bone tissue.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hidroxiapatita sustituida con Sr+2]]></kwd>
<kwd lng="es"><![CDATA[biomateriales para el tejido óseo, estroncio, bioactividad]]></kwd>
<kwd lng="en"><![CDATA[Sr-substituted hydroxyapatite]]></kwd>
<kwd lng="en"><![CDATA[bone tissue biomaterials]]></kwd>
<kwd lng="en"><![CDATA[strontium, bioactivity]]></kwd>
</kwd-group>
</article-meta>
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