<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev cubana med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232019000200002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hipotiroidismo primario, insulinorresistencia y la aterosclerosis carotídea subclínica]]></article-title>
<article-title xml:lang="en"><![CDATA[Primary hypothyroidism, insulin resistance, and subclinical carotid atherosclerosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Busto Mesa]]></surname>
<given-names><![CDATA[Abdel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos Robleda]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pulido Prieto]]></surname>
<given-names><![CDATA[Yunior Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pozo]]></surname>
<given-names><![CDATA[Silvia Maria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Hospital Clínico Quirúrgico 10 de Octubre ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>58</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232019000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232019000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232019000200002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El hipotiroidismo es considerado un factor de riesgo de enfermedad cardiovascular por su relación con la dislipidemia, la hipertensión arterial y la cardiopatía isquémica. En Cuba, después de la diabetes, ocupa el segundo lugar en la prevalencia de las enfermedades endocrinas.  Objetivo:  Identificar si existe relación entre la presencia de hipotiroidismo primario e insulinorresistencia y la aterosclerosis carotídea subclínica.  Métodos:  Se realizó un estudio analítico, multicéntrico, de corte transversal, en 150 pacientes divididos en dos grupos de comparación: 1) hipotiroidismo primario (n=75) y 2) insulinorresistencia sin hipotiroidismo (n=75) a los cuales se les realizaron procederes de laboratorio y ecográficos. Los pacientes fueron atendidos en las consultas de endocrinología de Hospital Clínico Quirúrgico 10 de Octubre, Hospital Miguel Enríquez y del Instituto Nacional de Endocrinología.  Resultados:  En el grupo con hipotiroidismo, los valores medios de índice de masa corporal, colesterol total, hormona estimulante de la tiroides y grosor íntima-media carotideo fueron significativamente mayores respecto a los insulinorresistentes. El HOMA-IR fue significativamente mayor en el grupo con insulinorresistencia. El valor de TSH &#8805; 4,20 µmol/L mostró sensibilidad de 95,5 % y especificidad de 73,3 % en la predicción de aumento del GIMC. El HOMA-IR &#8805;3,10 tuvo sensibilidad de 95,5 % y especificidad de 73,1 %.  Conclusiones:  El hipotiroidismo y la insulinorresistencia son predictores independientes de aterosclerosis carotídea subclínica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Hypothyroidism is considered a risk factor for cardiovascular disease due to its relationship with dyslipidemia, high blood pressure and ischemic heart disease. In Cuba, after diabetes, it ranks second in the prevalence of endocrine diseases.  Objective:  To identify if there is a relationship between the presence of primary hypothyroidism and insulin resistance and subclinical carotid atherosclerosis.  Methods:  An analytical, multicenter, cross-sectional study was carried out in 150 patients separated into two comparison groups: 1) primary hypothyroidism (n = 75) and 2) insulin resistance with no hypothyroidism (n = 75). They underwent laboratory and ultrasound procedures. The patients were treated at the endocrinology consultations from 10 de Octubre Clinical Surgical Hospital, Miguel Enríquez Hospital and the National Institute of Endocrinology.  Results:  The hypothyroidism group showed mean values of body mass index, total cholesterol, thyroid-stimulating hormone and carotid intima-media thickness significantly higher compared to insulin-resistant drugs. HOMA-IR was significantly higher in the insulin resistance group. TSH value &#8805; 4.20 µmol / L showed 95.5% sensitivity and 73.3% specificity in predicting GIMC increase. HOMA-IR &#8805; 3.10 had 95.5% sensitivity and 73.1% specificity.  Conclusions:  Hypothyroidism and insulin resistance are independent predictors of subclinical carotid atherosclerosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hipotiroidismo]]></kwd>
<kwd lng="es"><![CDATA[insulinorresistencia]]></kwd>
<kwd lng="es"><![CDATA[grosor íntima-media carotideo]]></kwd>
<kwd lng="en"><![CDATA[hypothyroidism]]></kwd>
<kwd lng="en"><![CDATA[insulin resistance]]></kwd>
<kwd lng="en"><![CDATA[carotid intima-media thickness]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parlá Sardiñas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hipotiroidismo]]></article-title>
<source><![CDATA[Rev Cubana Endocrinol]]></source>
<year>2012</year>
<volume>23</volume>
<page-range>208-12</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pando Álvarez]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Torres Aparcana]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
<name>
<surname><![CDATA[Arbañil Huamán]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Aliaga Herrera]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aterosclerosis subclínica y perfil metabólico en mujeres asintomáticas de edad media, con TSH = 2,5 uUI/mL]]></article-title>
<source><![CDATA[An Fac Med]]></source>
<year>2012</year>
<volume>73</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kilic]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Tanriverdi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Fenkci]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Akin]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Uslu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kaftan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Noninva-sive indicators of atherosclerosis in subclinical hypothyroidism]]></article-title>
<source><![CDATA[Indian J Endocrinol Metab]]></source>
<year>2013</year>
<volume>17</volume>
<page-range>271-5</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calderín Bouza]]></surname>
<given-names><![CDATA[RO]]></given-names>
</name>
<name>
<surname><![CDATA[Yanes Quesada]]></surname>
<given-names><![CDATA[MÁ]]></given-names>
</name>
<name>
<surname><![CDATA[Yanes Quesada]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez Paneque]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández-Britto Rodríguez]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[León Álvarez]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Propuesta de clasificación cubana para el estudio del síndrome de insulinorresistencia en pacientes dislipidémicos]]></article-title>
<source><![CDATA[Acta Médica de Cuba]]></source>
<year>2017</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cabrera Rego]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Gandarilla Sarmientos]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[del Busto Mesa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Valiente Mustelier]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Grasa epicárdica y su asociación con el HOMA-IR y el grosor íntima-media carotideo]]></article-title>
<source><![CDATA[Rev Argent Cardiol]]></source>
<year>2012</year>
<volume>80</volume>
<page-range>223-30</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Busto Mesa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cabrera Rego]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Gandarilla]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Valiente]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insulinorresistencia y su asociación con aterosclerosis carotidea subclínica]]></article-title>
<source><![CDATA[Rev Cubana Cardiol Cir Cardiovasc]]></source>
<year>2011</year>
<volume>17</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>167-75</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Busto Mesa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cabrera Rego]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Carrero Fernández]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández Roca]]></surname>
<given-names><![CDATA[CV]]></given-names>
</name>
<name>
<surname><![CDATA[González Valdés]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[de la Rosa Pazos]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Endocrinol Nutr]]></source>
<year>2015</year>
<volume>62</volume>
<page-range>270-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arranz]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Utilización de un método rápido para la separación de la hormona libre y unida en el radioinmunoensayo de insulina]]></article-title>
<source><![CDATA[Rev Cubana Invest Biomed]]></source>
<year>1988</year>
<volume>7</volume>
<page-range>150-6</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Pedro S]]></surname>
<given-names><![CDATA[Benozzi S]]></given-names>
</name>
<name>
<surname><![CDATA[Becerra H]]></surname>
<given-names><![CDATA[Bonacorsi SM]]></given-names>
</name>
<name>
<surname><![CDATA[Jouffré G]]></surname>
<given-names><![CDATA[Kriplianski]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factores de riesgo cardiovascular en pacientes con hipotiroidismo subclínico]]></article-title>
<source><![CDATA[Rev Argent Endocrinol Metab]]></source>
<year>2012</year>
<volume>49</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Takamura]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Akilzhanova]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hayashida]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Kadota]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Yamasaki]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Usa]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thyroid function is associated with carotid intima-media thickness in euthyroid subjects]]></article-title>
<source><![CDATA[Atherosclerosis]]></source>
<year>2013</year>
<volume>204</volume>
<page-range>77-81</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Biondi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of hyperthyroidism on the cardiovascular and musculoskeletal systems and management of patients with subclinical Graves' Disease]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Bahn]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
</person-group>
<source><![CDATA[Grave's Disease]]></source>
<year>2015</year>
<page-range>133-46</page-range><publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[Springer]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moura Souza]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Herrera]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Leiva]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insulin resistance and changes in thyrotropin levels in patients with euthyroidism or subclinic thyroid dysfunction. Insulinorresistencia y nivel de TSH]]></article-title>
<source><![CDATA[Rev Argent Endocrinol]]></source>
<year>2014</year>
<volume>49</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanyal]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Raychaudhuri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hypothyroidism and obesity An intriguing link]]></article-title>
<source><![CDATA[Indian J Endocrinol Metab]]></source>
<year>2016</year>
<volume>20</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>554</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nagasaki]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Inaba]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Henmi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kumeda]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ueda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tahara]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Decrease in carotid intima media thickness in hypothyroid patients after normalization of thyroid function]]></article-title>
<source><![CDATA[Clin Endocrinol]]></source>
<year>2003</year>
<volume>59</volume>
<page-range>607-12</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Leite]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Salles]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Waisman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism]]></article-title>
<source><![CDATA[Clinics]]></source>
<year>2011</year>
<volume>66</volume>
<page-range>1321-7</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[YZ]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carotid intima-media thickness in patients with subclinical hypothyroidism a meta-analysis]]></article-title>
<source><![CDATA[Atherosclerosis]]></source>
<year>2013</year>
<volume>227</volume>
<page-range>18-25</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
