<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Cuban de Med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232024000100006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Pénfigo paraneoplásico manifestación inicial de tumor renal]]></article-title>
<article-title xml:lang="en"><![CDATA[Paraneoplastic Pemphigus Initial Manifestation of Renal Tumor]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortúzar Menesia]]></surname>
<given-names><![CDATA[Elisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alduenda Ceja]]></surname>
<given-names><![CDATA[José Ramón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mudarra De León]]></surname>
<given-names><![CDATA[Rita Madgledys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Pérez]]></surname>
<given-names><![CDATA[Kirenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>63</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232024000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232024000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232024000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El pénfigo paraneoplásico es una enfermedad ampollosa autoinmune asociada a una neoplasia oculta o previamente diagnosticada con manifestaciones clínicas, histológicas e inmunológicas bien definidas.  Objetivo: Presentar pénfigo paraneoplásico asociado a tumor renal.  Presentación de caso:  Se presentó un paciente de sexo masculino de 47 años con antecedentes de asma bronquial desde la infancia, con hipertensión arterial hace tres años; además, de tener catarata y reflujo gastroesofágico por hernia hiatal. El motivo de su ingreso fue por lesiones erosivas de la mucosa oral, dolorosas con costras hemorrágicas y saliveo con afectación de carrillos, lengua, encías; además de lesiones en la mucosa conjuntival y nasal. En la histopatología se observó acantólisis y queratinocitos necróticos respectivamente. La presencia de tumor renal confirmó el diagnóstico. Se realizó una embolización de tumor renal conjuntamente con altas dosis de corticosteroides para sus lesiones cutáneo mucosas, con buena respuesta a dicho tratamiento, aunque es infrecuente la presencia de pénfigo paraneoplásico asociado a tumor renal, se debe tener en cuenta entre los diagnósticos diferenciales de las dermatosis erosivas periorificiales.  Conclusiones:  Es esencial reconocer la importancia de la correlación de los hallazgos clinicopatológico e inmunológicos en el pénfigo paraneoplásico, así como la posibilidad de que se produzcan presentaciones que urjan la pronta confirmación y evaluación inmunopatológicas de una neoplasia oculta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introducción:  Paraneoplastic pemphigus is an autoimmune blistering disease associated with an occult or previously diagnosed neoplasia, with well-defined clinical, histological and immunological manifestations.  Objective:  To present paraneoplastic pemphigus associated with kidney tumor.  Case report:  A 47-year-old male patient was reported, with a history of bronchial asthma since childhood, high blood pressure for three years, in addition to having cataract and gastroesophageal reflux due to hiatal hernia, motivating his admission due to erosive lesions of his oral mucosa, painful with hemorrhagic crusts and saliva affecting the cheeks, tongue, gums, as well as lesions in the conjunctival and nasal mucosa. Histopathology revealed acantholysis and necrotic keratinocytes, respectively. The presence of a kidney tumor confirmed the diagnosis. Embolization of the kidney tumor was performed together with high doses of corticosteroids for the cutaneous-mucosal lesions, with good response to said treatment, although the presence of paraneoplastic pemphigus associated with a kidney tumor is rare and should be taken into account among the differential diagnoses of periorificial erosive dermatoses.  Conclusions:  It is essential to recognize the importance of the correlation of clinicopathological and immunological findings in paraneoplastic pemphigus, as well as the possibility of presentations that require prompt confirmation and immunopathological evaluation of an occult neoplasia.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[pénfigo paraneoplásico]]></kwd>
<kwd lng="es"><![CDATA[tumor renal]]></kwd>
<kwd lng="es"><![CDATA[estomatitis oral]]></kwd>
<kwd lng="en"><![CDATA[paraneoplastic pemphigus]]></kwd>
<kwd lng="en"><![CDATA[kidney tumor]]></kwd>
<kwd lng="en"><![CDATA[oral stomatitis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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