0138-6557 0138-6557 S0138-65572021000100017 Cuba Cuba Cuba 00 03 2021 00 03 2021 50 1

1 Organización Panamericana para la Salud 2005 2 Centro para el Control Estatal de Medicamentos, Equipos y Dispositivos Médicos 2000 3 United States Department of Health and Human Services Food and Drug Administration 2018 4 2001 5 2012 129 3 3 6 2017 14 1 1 7 2002 21 8 2015 49 5 5 9 2014 onible 10 2016 316 22 22 2359-60 11 2017 42 4 4 12 2019 2 13 2016 42 4 4 14 2016 50 5 5 648-59 15 Canadian Cancer Trials Group 2017 16 DEMOCLES Study Group 2005 365 9460 9460 711-22 17 Past SOCRA source articles 2003 18 2019 3 19 2017 18 120 20 Food and Drug Administration 2006 21 European Medicines Agency 2005 onible 22 National Health and Medical Research Council 2018 23 25/0 3/ 20 24 Turkish Medicine and Medical Device Agency 2013 25 Special Programmer for Research and Training in Tropical Diseases 2005 26 U.S. Department of Health and Human Services 2017 27 2015 33 3 3 143-8 28 2007 33 1815-8 29 2016 30 2008 61 3 3 241-6 31 CTSA Collaborative DSMB Workgroup 2018 32 2017 14 4 4 342-8