<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0253-570X</journal-id>
<journal-title><![CDATA[Revista de Salud Animal]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Salud Anim.]]></abbrev-journal-title>
<issn>0253-570X</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Sanidad Agropecuaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0253-570X2019000200001</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Assessment of the Ecuadorian ECJB 2000 isolate of classical swine fever virus as challenge strain]]></article-title>
<article-title xml:lang="es"><![CDATA[Evaluación del aislamiento ecuatoriano ECJB 2000 del virus de la peste porcina clásica como cepa de desafío]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santafé-Huera]]></surname>
<given-names><![CDATA[Viviana Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrera-Valle]]></surname>
<given-names><![CDATA[Maritza Isidra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrionuevo-Samaniego]]></surname>
<given-names><![CDATA[Margoth Yolanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sotomayor-Ramos]]></surname>
<given-names><![CDATA[William Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garrido-Haro]]></surname>
<given-names><![CDATA[Ana Dolores]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta-Batallas]]></surname>
<given-names><![CDATA[Alfredo Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Baquero-Cárdenas]]></surname>
<given-names><![CDATA[María I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Central del Ecuador Facultad de Medicina Veterinaria y Zootecnia ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,AGROCALIDAD, Agencia Ecuatoriana de Aseguramiento de la Calidad del Agro  ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,James Brown Pharma  ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Técnica de Manabí Facultad de Ciencias Veterinarias ]]></institution>
<addr-line><![CDATA[Portoviejo Manabí]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>41</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0253-570X2019000200001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0253-570X2019000200001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0253-570X2019000200001&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Classical swine fever (CSF) is an infectious disease responsible for high economic losses in pigs of all ages. Several programs for the control and eradication of this disease have been implemented at a global level, being vaccination the principal mechanism. This research had the purpose of identifying the pathogenicity of an isolated circulating strain in Ecuador, and determining the efficacy of the vaccine applied for prevention. Animals were challenged with decreasing doses of the viral strain ECJB 2000 to obtain 10 median infective doses of this strain in pigs (DI50). Afterward, the efficacy of a vaccine of the lapinized Chinese strain was evaluated against the virus of porcine cholera adapted to a cell culture line derived from a miniature pig kidney (MPK-LC-HCV), averaging a trial potency following the standard protocol of the World Organization for Animal Health (OIE). The vaccine was applied at different dilutions, and 14 days later, a viral challenge was done with DI50. The unimmunized pigs presented clinical signs from day three post-infection, and the statistical results did not show significant differences in the body temperature registers and leukocyte count. Spearman-Kärber&#8217;s trial determined that the vaccine contained 239.88 protective doses (DI50); taking into account that an effective vaccine against classical swine fever virus (CSFV) must have a value of &gt; 100. This study demonstrated that the circulating strain in Ecuador is of elevated pathogenicity and that the vaccine is effective for the control of the disease.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La peste porcina clásica (PPC) es una enfermedad infecciosa responsable de altas pérdidas económicas en cerdos de todas las edades. Varios programas para el control y la erradicación de esta enfermedad se han implementado a nivel mundial, pero el mecanismo principal es la vacunación. Esta investigación tuvo como objetivo determinar la patogenicidad de una cepa circulante aislada en Ecuador y determinar la eficacia de la vacuna aplicada para la prevención. Los animales fueron desafiados con dosis decrecientes de la cepa viral ECJB 2000 para obtener 10 dosis infectivas medianas de esta cepa (DI50) en cerdos. Posteriormente, se evaluó la eficacia de una vacuna de la cepa china lapinizada contra el virus del cólera porcino, adaptado a una línea de cultivo celular derivada de riñón de cerdo en miniatura (MPK-LC-HCV), promediando una potencia de prueba y siguiendo el protocolo estándar de la Organización Mundial de Sanidad Animal (OIE). La vacuna se aplicó a diferentes diluciones y, a los catorce días de aplicada, se realizó un desafío viral con DI50. Los cerdos no inmunizados presentaron signos clínicos desde el día 3, posterior a la infección. Los resultados no mostraron diferencias significativas en los registros de temperatura corporal y en el recuento de leucocitos. El ensayo de Spearman-Kärber determinó que la vacuna contenía 239,88 dosis protectoras (DI50), si se tiene en cuenta que una vacuna eficaz contra el virus de la peste porcina clásica (CSFV) debe tener un valor &gt; 100. Este estudio demostró que la cepa circulante en Ecuador tiene una patogenicidad elevada y la vacuna es eficaz para el control de la enfermedad.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Classical Swine Fever]]></kwd>
<kwd lng="en"><![CDATA[efficacy]]></kwd>
<kwd lng="en"><![CDATA[challenge]]></kwd>
<kwd lng="en"><![CDATA[immunization]]></kwd>
<kwd lng="en"><![CDATA[strain ECJB 2000]]></kwd>
<kwd lng="es"><![CDATA[cepa ECJB 2000]]></kwd>
<kwd lng="es"><![CDATA[desafío]]></kwd>
<kwd lng="es"><![CDATA[eficacia]]></kwd>
<kwd lng="es"><![CDATA[inmunización]]></kwd>
<kwd lng="es"><![CDATA[Peste Porcina Clásica]]></kwd>
</kwd-group>
</article-meta>
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