<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0375-0760</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Trop]]></abbrev-journal-title>
<issn>0375-0760</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0375-07602005000100016</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Probable areas of infection and ambience of occurrence of human leptospirosis in Brazil (2001-2003)]]></article-title>
<article-title xml:lang="es"><![CDATA[Áreas probables de infección y ambiente de ocurrencia de leptospirosis humana en Brasil (2001-2003)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Simões Arsky]]></surname>
<given-names><![CDATA[Maria de Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kleber Oliveira]]></surname>
<given-names><![CDATA[Wanderson]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cerqueira Oliveira]]></surname>
<given-names><![CDATA[Rosely]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Strugo Arruda]]></surname>
<given-names><![CDATA[Aderbal Henry]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,National Health Surveillance Secretary, Brazilian Ministry of Heatlh  ]]></institution>
<addr-line><![CDATA[Brasília/DF ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2005</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2005</year>
</pub-date>
<volume>57</volume>
<numero>1</numero>
<fpage>59</fpage>
<lpage>60</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0375-07602005000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0375-07602005000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0375-07602005000100016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[It was studied the probable location of infection (PLI/area) and ambience of occurrence of human Leptospirosis cases, confirmed by laboratory report in Brazil from 2001 to 2003. The disease had more connection to the urban and suburban areas, suggesting that the occurrence of the disease is related to the life conditions and housing sanitation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Se estudió la ubicación probable de la infección (PLI/área) y ambiente de ocurrencia de casos de leptospirosis en humanos confirmados mediante informe de laboratorio en Brasil de 2001 a 2003. La enfermedad estaba más relacionada con las áreas urbanas y suburbanas, lo que sugiere que la ocurrencia de la enfermedad está vinculada con las condiciones de vida y la higiene de la vivienda.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Leptospirosis]]></kwd>
<kwd lng="en"><![CDATA[ambience]]></kwd>
<kwd lng="en"><![CDATA[PLI/area]]></kwd>
<kwd lng="es"><![CDATA[Leptospirosis]]></kwd>
<kwd lng="es"><![CDATA[ambiente]]></kwd>
<kwd lng="es"><![CDATA[PLI/área]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <div class=Section1>          <p class=MsoNormal><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>National Health Surveillance Secretary, Brazilian</span></span></p>   <h2 class=MsoNormal><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>Probable areas of infection and ambience of occurrence      of human <span class=SpellE>leptospirosis</span> in </span></span><st1:country-region><st1:place><span   style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>Brazil</span></span></st1:place></st1:country-region><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>      (2001-2003)</span></span></h2>       <p class=MsoNormal><span style='mso-bookmark:arsky1'><span lang=PT-BR style='mso-ansi-language:PT-BR'><a href="#creditos">Dr. Maria de Lourdes Simões<span style='mso-bidi-font-weight:bold'> Arsky,<sup>1</sup></span> Mr. Wanderson Kleber      Oliveira,<sup>2</sup> Dr. Rosely Cerqueira Oliveira,<sup>3</sup> y Dr. Aderbal      Henry Strugo Arruda<sup>4</sup></a><sup><a name="autores"></a></sup></span></span></p>   <h4 class=MsoNormal><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>Summary</span></span></h4>       <p class=MsoNormal><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>It was studied the probable location of infection      (PLI/area) and ambience of occurrence of human <span class=SpellE><i style='mso-bidi-font-style:normal'>Leptospirosis</i></span> cases, confirmed by      laboratory report in </span></span><st1:country-region><st1:place><span   style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>Brazil</span></span></st1:place></st1:country-region><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'>      from 2001 to 2003. The disease had more connection to the urban and suburban      areas, suggesting that the occurrence of the disease is related to the life      conditions and housing sanitation.</span></span></p>       <p class=MsoNormal><span style='mso-bookmark:arsky1'><span lang=EN-US style='mso-ansi-language:EN-US'><b>Key words</b>: <span class=SpellE>Leptospirosis</span>,      ambience, PLI/area.</span></span></p>   <span style='mso-bookmark:arsky1'></span>        <p class=MsoNormal>&nbsp;</p>       <p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>The <span class=SpellE>leptospirosis</span> is one of the important zoonosis in our environment,      bringing sanitary and economical problems to men.<sup>1</sup> <span class=GramE>The</span> disease occurs on rural and urban ambiences. At the urban      areas, the cases are more emphatic due to many factors as high density of      low-income population, living in inhospitable condition concerning sanitation,      occurrence of intense rain showers and high population of rodents.<sup>1-5</sup>      From 2001 to 2003, there were 34.599 notified cases of Leptospirosis in Brazil      from that amount, 7.818 was confirmed. Objective: Analyze the probable location      of infection (PLI/area) and ambience of occurrence of human Leptospirosis      cases, confirmed by lab report in </span><st1:country-region><st1:place><span   lang=EN-US style='mso-ansi-language:EN-US'>Brazil</span></st1:place></st1:country-region><span lang=EN-US style='mso-ansi-language:EN-US'> from 2001 to 2003.</span></p>       <p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>The data      used was the ones from the <span class=SpellE>Sistema</span> <span class=SpellE>Nacional</span> de <span class=SpellE>Notificação</span>/SINAN (National      System of Notification) from the years of 2001 to 2003</span></p>       <p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>During 2001      to 2003 from the total of 7.818 confirmed cases of the disease, 3.747 (48      %) that were confirmed by laboratory criteria and with determined PLI epidemiological      investigation were investigated. After that, was observed that 2.687 cases      (72 %) had occurred in urban/suburban areas. At those areas, 1.746 (65 %)      had occurred in domicile ambience, 624 (23<span class=GramE>,2</span> %) in      labor ambience and 317 (11,8 %) in leisure ambience. In rural areas, was observed      1.060 cases (28<span class=GramE>,2</span> % of the total), being 297 (28      %) in domicile ambience, 572 (54 %) in labor ambience and 180 (17 %) in leisure      ambience. </span></p>       <p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>Analyzing      the ambience factor, were observed the domiciles ambience appeared in 2.043      cases (55 % of the total), labor ambience (32 %) and leisure ambience (13      % of the total)</span></p>       ]]></body>
<body><![CDATA[<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>After these      results, one can conclude that during the analyzed period the disease had      more connection to the urban and suburban areas, and the domicile ambience      was more frequent than the others, suggesting that the occurrence of the disease      is related to the life conditions and housing sanitation. The importance of      a program to make the ambiences inappropriate to the installation and procreation      of rodents, allied to an improvement of the sanitary infrastructure are essentials      at the control the disease in </span><st1:country-region><st1:place><span   lang=EN-US style='mso-ansi-language:EN-US'>Brazil</span></st1:place></st1:country-region><span lang=EN-US style='mso-ansi-language:EN-US'>. </span></p>       <p class=MsoNormal>&nbsp;</p>   <h2 class=MsoNormal><span style='mso-ansi-language:ES-MX'>Áreas probables de      infección y ambiente de ocurrencia de <span class=SpellE>leptospirosis</span>      humana en Brasil (2001-2003)</span></h2>   <h4 class=MsoNormal><span lang=ES>Resumen</span></h4>       <p class=MsoNormal><span style='mso-ansi-language:ES-MX'>Se estudió la ubicación      probable de la infección (PLI/área) y ambiente de ocurrencia de casos de <span class=SpellE>leptospirosis</span>      en humanos confirmados mediante informe de laboratorio en Brasil de 2001 a      2003. La enfermedad estaba más relacionada con las áreas urbanas y suburbanas,      lo que sugiere que la ocurrencia de la enfermedad está vinculada con las condiciones      de vida y la higiene de la vivienda. </span></p>       <p class=MsoNormal><span lang=PT-BR style='mso-ansi-language:PT-BR'><b>Palabras      clave</b>: Leptospirosis, ambiente, PLI/área.</span></p>       <!-- ref --><p class=MsoNormal>&nbsp;<!-- ref -->WHO. Human leptospirosis: guidance        for diagnosis, surveillance and control. </span><st1:country-region><st1:place><span        lang=EN-US style='mso-ansi-language:EN-US'>Malta</span></st1:place></st1:country-region><span      lang=EN-US style='mso-ansi-language:EN-US'>, 2003.</span></li>     <li class=MsoNormal style='mso-list:l2 level1 lfo3;'><span      lang=PT-BR style='mso-ansi-language:PT-BR'>    <!-- ref -->Brasil. Manual de leptospirose.        4 ed. Brasília: Ministério da Saúde, Fundação Nacional de Saúde, 1999. </span></li>     <li class=MsoNormal style='mso-list:l2 level1 lfo3;'><span      lang=PT-BR style='mso-ansi-language:PT-BR'>    <!-- ref -->Brasil. Manual de controle de        roedores. Brasília: Ministério da Saúde, Fundação Nacional de Saúde, 2002.</span></li>     <li class=MsoNormal style='mso-list:l2 level1 lfo3;'><span      lang=PT-BR style='mso-ansi-language:PT-BR'>    <!-- ref -->Brasil. Leptospirose. In: Guia        de vigilância epidemiológica. 5 ed. Brasília: Ministério da Saúde, Fundação        Nacional de Saúde, 2002.</span></li>    </ol>       ]]></body>
<body><![CDATA[<p class=MsoNormal><span lang=PT-BR style='mso-ansi-language:PT-BR'>Recibido:      27 de diciembre de 2004. Aprobado: 10 de marzo de 2005.    <br>     </span><span lang=PT-BR style='mso-ansi-language:PT-BR'>Dr. <i style='mso-bidi-font-style:normal'>Maria de Lourdes Simões<span style='mso-bidi-font-weight:bold'> Arsky</span></i></span><span lang=FR style='mso-ansi-language:FR'>. </span><span lang=EN-US style='mso-ansi-language: EN-US'>National Health Surveillance Secretary, Brazilian Ministry of <span class=SpellE>Heatlh</span>, SAS Quadra 4 <span class=SpellE>Bloco</span> N- <span class=SpellE>Sala</span> 709, Brasília/DF – </span><st1:country-region><st1:place><span   lang=EN-US style='mso-ansi-language:EN-US'>Brazil</span></st1:place></st1:country-region><span lang=EN-US style='mso-ansi-language:EN-US'>, ZIP: 70. 070- 040. Fax: (55 61) 321      0544. E-mail<span style='mso-bidi-font-weight:bold'>:</span><i><span style='mso-bidi-font-weight:bold'>      </span></i><span style='color:windowtext; text-decoration:none;text-underline:none'><a href="mailto:%20lourdes.simoes@funasa.gov.br">lourdes.simoes@funasa.gov.br</a></span><i><span style='mso-bidi-font-weight:bold'>&nbsp;</span></i></span></p>       <p class=MsoNormal><span class=GramE><sup><span lang=EN-US style='mso-ansi-language: EN-US'><a href="#autores">1 </a></span></sup><a href="#autores"><span lang=EN-US style='mso-ansi-language:EN-US'>Veterinary      with Specialization in Public Health.</span></a></span><a href="#autores"><span lang=EN-US style='mso-ansi-language:EN-US'> <span class=SpellE>Leptospirosis</span> Surveillance      National Program.    <br>     </span></a><a href="#autores"><sup><span lang=EN-US style='mso-ansi-language:EN-US'>2      </span></sup><span class=GramE><span lang=EN-US style='mso-ansi-language:EN-US'>Nurse</span></span><span lang=EN-US style='mso-ansi-language:EN-US'> with Specialization in Epidemiology.      <span class=GramE>CDC/Atlanta/<span class=SpellE>Brasil</span>.    <br>     </span></span></a><a href="#autores"><sup><span lang=EN-US style='mso-ansi-language:EN-US'>3</span></sup><span lang=EN-US style='mso-ansi-language:EN-US'> Doctor with Specialization in Public      Health and Epidemiology- Coordinator of Coordination of Vectors Transmitted      Diseases and <span class=SpellE>Antropozoonosis</span>. <span class=SpellE>Departament</span> of Epidemiological Surveillance    <br>     </span></a><a href="#autores"><span class=GramE><sup><span lang=EN-US style='mso-ansi-language: EN-US'>4</span></sup><span lang=EN-US style='mso-ansi-language:EN-US'> Doctor      Master in Epidemiology.</span></span></a><span lang=EN-US style='mso-ansi-language: EN-US'><a name="creditos"></a></span></p>  </div>      ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Faine]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Leptospira and Leptospirosis]]></source>
<year>1994</year>
<publisher-loc><![CDATA[Boca Ratón ]]></publisher-loc>
<publisher-name><![CDATA[CRC Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="">
<collab>WHO</collab>
<source><![CDATA[Human leptospirosis: guidance for diagnosis, surveillance and control. Malta]]></source>
<year>2003</year>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="book">
<source><![CDATA[Manual de leptospirose]]></source>
<year>1999</year>
<edition>4</edition>
<publisher-loc><![CDATA[Brasília ]]></publisher-loc>
<publisher-name><![CDATA[Ministério da Saúde, Fundação Nacional de Saúde]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="book">
<source><![CDATA[Manual de controle de roedores]]></source>
<year>2002</year>
<publisher-loc><![CDATA[Brasília ]]></publisher-loc>
<publisher-name><![CDATA[Ministério da Saúde, Fundação Nacional de Saúde]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="book">
<article-title xml:lang="pt"><![CDATA[Leptospirose]]></article-title>
<source><![CDATA[Guia de vigilância epidemiológica]]></source>
<year>2002</year>
<edition>5</edition>
<publisher-loc><![CDATA[Brasília ]]></publisher-loc>
<publisher-name><![CDATA[Ministério da Saúde, Fundação Nacional de Saúde]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
