<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0375-0760</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Trop]]></abbrev-journal-title>
<issn>0375-0760</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0375-07602021000100004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación preliminar de la actividad de Ageratina havanensis contra virus dengue 2]]></article-title>
<article-title xml:lang="en"><![CDATA[Preliminary evaluation of the activity of Ageratina havanensis against the dengue 2 virus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Barrio Alonso]]></surname>
<given-names><![CDATA[Gloria del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jardines Figueredo]]></surname>
<given-names><![CDATA[Yenisey]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spengler Salabarría]]></surname>
<given-names><![CDATA[Iraida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Pérez]]></surname>
<given-names><![CDATA[Trina Haydee]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roque Quintero]]></surname>
<given-names><![CDATA[Annele]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarez Vera]]></surname>
<given-names><![CDATA[Mayling]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Facultad de Biología Departamento de Microbiología y Virología]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de La Habana Facultad de Química Centro de Estudios de Productos Naturales]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Medicina Tropical &#8220;Pedro Kourí&#8221; Laboratorio Nacional de Referencia de Arbovirus ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<volume>73</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0375-07602021000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0375-07602021000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0375-07602021000100004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El dengue es la enfermedad viral transmitida por mosquitos de más rápida propagación en el mundo. A pesar de la alta incidencia de la enfermedad no existe tratamiento antiviral efectivo ni vacuna aprobada para su uso contra esta infección. La planta Ageratina havanensis ha sido ampliamente utilizada por nuestra cultura popular y en otros países debido a sus diversas propiedades biológicas.  Objetivo:  Evaluar la actividad antiviral de cuatro extractos provenientes de Ageratina havanensis y dos flavonoides aislados de dicha planta frente al virus dengue 2.  Métodos:  La pesquisa primaria de actividad antiviral de cada extracto y flavonoide se realizó mediante el ensayo de detección de la productividad vírica, y se evaluó la acción virucida de los extractos etanólico de tallo y butanólico de hoja.  Resultados:  Todos los extractos inhibieron la replicación viral al evidenciarse disminución del número de placas de lisis, sin embargo, no se evidenció disminución del título infectivo viral en el ensayo virucida. El tratamiento con la sakuranetina mostró valores de inhibición de la productividad viral entre 61-91 %, y para la 7-metoxiaromadendrina se registraron valores de reducción viral entre 64-86 %.  Conclusiones:  Los extractos y flavonoides aislados de Ageratina havanensis mostraron acción antiviral. Los extractos etanólico de tallo y butanólico de hojas no poseen acción virucida sobre la cepa viral empleada. El presente trabajo constituye el primer informe respecto a la evaluación de extractos y compuestos aislados de A. havanensis frente al virus dengue.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Dengue is the fastest spreading mosquito-borne viral disease worldwide. Despite its high incidence, no effective antiviral treatment or vaccine has been approved for use against this infection. The plant Ageratina havanensis has been widely used in our folk culture and in other countries due to its various biological properties.  Objective:  Evaluate the antiviral activity of four extracts from Ageratina havanensis and two flavonoids isolated from that plant against the dengue 2 virus.  Methods:  Primary screening of the antiviral activity of each extract and flavonoid was conducted by viral productivity detection assay, and an evaluation was carried out of the virucidal action of the stem ethanolic extract and the leaf butanolic extract.  Results:  All the extracts inhibited viral replication by a reduction in the number of lysis plates. However, no evidence was found of a reduced viral infective titer in the virucidal assay. Treatment with sakuranetin achieved viral productivity inhibition values of 61%-91%, whereas 7-methoxyaromadendrin obtained viral reduction values of 64%-86%.  Conclusions:  The extracts and flavonoids isolated from Ageratina havanensis displayed antiviral activity. The stem ethanolic extract and the leaf butanolic extract do not have a virucidal action against the viral strain used. The paper is the first report about the effect of extracts and compounds isolated from A. havanensis against the dengue virus.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ageratina havanensis]]></kwd>
<kwd lng="es"><![CDATA[antiviral]]></kwd>
<kwd lng="es"><![CDATA[dengue]]></kwd>
<kwd lng="es"><![CDATA[flavonoides]]></kwd>
<kwd lng="es"><![CDATA[productos naturales]]></kwd>
<kwd lng="en"><![CDATA[Ageratina havanensis]]></kwd>
<kwd lng="en"><![CDATA[antiviral]]></kwd>
<kwd lng="en"><![CDATA[dengue]]></kwd>
<kwd lng="en"><![CDATA[flavonoids]]></kwd>
<kwd lng="en"><![CDATA[natural products]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stuart]]></surname>
<given-names><![CDATA[TP]]></given-names>
</name>
<name>
<surname><![CDATA[Buck]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Shresta]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Better late than never antivirals for dengue]]></article-title>
<source><![CDATA[Expert Rev Anti Infect Ther]]></source>
<year>2011</year>
<volume>9</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>755-7</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gubler]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kuno]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Markoff]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flaviviruses]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Knipe]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Holey]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<source><![CDATA[Fields of Virology]]></source>
<year>2007</year>
<edition>5th</edition>
<page-range>1153-252</page-range><publisher-name><![CDATA[Wolters Kluwer and Lippincott Williams &amp; Wilkins]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Costa da Silveira Oliveira]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Silva de Oliveira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martins de Souza]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes da Silva]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira de Paula]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2017</year>
<volume>22</volume>
<page-range>505</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="book">
<collab>WHO</collab>
<source><![CDATA[Dengue: guidelines for diagnosis, treatment, prevention, and control Spec Program Res]]></source>
<year>2009</year>
<page-range>47</page-range><publisher-name><![CDATA[Train Trop Dis]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[WL]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[de Oliveira]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Natural Products as Source of Potential Dengue Antivirals]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2014</year>
<volume>9</volume>
<page-range>8151-76</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[del Barrio]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Spengler]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Roque]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Calderón]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiviral activity of Ageratina havanensis and major chemical compounds from the most active fraction]]></article-title>
<source><![CDATA[Brazilian Journal of Pharmacognosy]]></source>
<year>2011</year>
<volume>21</volume>
<page-range>915-20</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[TH]]></given-names>
</name>
<name>
<surname><![CDATA[Quintino da Rocha]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[ll]]></surname>
<given-names><![CDATA[Pino]]></given-names>
</name>
<name>
<surname><![CDATA[del Barrio]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Roque]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of the qualitative chemical composition o extracts from Ageratina havanenesis collected in two different phenological stages by FIA-ESI-IT-MSn and UPLC/ESI-MSn Antiviral activity]]></article-title>
<source><![CDATA[Natural Product Communications]]></source>
<year>2017</year>
<volume>1</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1-152</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mosmann]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxicity assays]]></article-title>
<source><![CDATA[J Immunol Meth]]></source>
<year>1983</year>
<numero>65</numero>
<issue>65</issue>
<page-range>55-63</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alvarez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez-Roche]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
<name>
<surname><![CDATA[Morier]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Guzmán]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
</person-group>
<source><![CDATA[Improved Dengue Virus Plaque Formation on BHK21 and LLCMK2 Cells: Evaluation of Some Factors]]></source>
<year>2005</year>
<page-range>29</page-range><publisher-name><![CDATA[Bulletin Dengue]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gubler]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dengue/dengue haemorrhagic fever: history and current status]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Bock]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Goode]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[New treatment strategies for dengue and other flaviviral diseases]]></source>
<year>2006</year>
<publisher-loc><![CDATA[Chichester ]]></publisher-loc>
<publisher-name><![CDATA[Novartis Foundation]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gubler]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kuno]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Markoff]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Flaviviruses]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Knipe]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Holey]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<source><![CDATA[Fields of Virology]]></source>
<year>2007</year>
<edition>5th</edition>
<page-range>1153-252</page-range><publisher-name><![CDATA[Wolters Kluwer and Lippincott Williams &amp; Wilkins]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abd Kadir]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Potential anti-dengue medicinal plants a review]]></article-title>
<source><![CDATA[J Nat Med]]></source>
<year>2013</year>
<volume>67</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>677-89</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singh]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Rawat]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evolving herbal formulations in management of dengue fever]]></article-title>
<source><![CDATA[Journal of Ayurveda and Integrative Medicine]]></source>
<year>2017</year>
<volume>8</volume>
<page-range>207-10</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaushik]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kaushik]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Yadav]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiviral and therapeutic uses of medicinal plants and their derivatives against dengue viruses]]></article-title>
<source><![CDATA[Phcog Rev]]></source>
<year>2018</year>
<volume>12</volume>
<page-range>177-85</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ali-Seyed]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Vijayaraghavan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dengue virus infections and anti-dengue virus activities of Andrographis paniculata]]></article-title>
<source><![CDATA[Asian Pac J Trop Med]]></source>
<year>2020</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>49-55</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Talarico]]></surname>
<given-names><![CDATA[LB]]></given-names>
</name>
<name>
<surname><![CDATA[Pujol]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Zibetti]]></surname>
<given-names><![CDATA[RGM]]></given-names>
</name>
<name>
<surname><![CDATA[Faría]]></surname>
<given-names><![CDATA[PCS]]></given-names>
</name>
<name>
<surname><![CDATA[Noseda]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Duarte]]></surname>
<given-names><![CDATA[MER]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell]]></article-title>
<source><![CDATA[Antiviral Research]]></source>
<year>2005</year>
<volume>66</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>103-10</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Talarico]]></surname>
<given-names><![CDATA[LB]]></given-names>
</name>
<name>
<surname><![CDATA[Damonte]]></surname>
<given-names><![CDATA[EB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interference in dengue virus adsorption and uncoating by carrageenans]]></article-title>
<source><![CDATA[Virol]]></source>
<year>2007</year>
<volume>363</volume>
<page-range>473-85</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Talarico]]></surname>
<given-names><![CDATA[LB]]></given-names>
</name>
<name>
<surname><![CDATA[Noseda]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Ducatti]]></surname>
<given-names><![CDATA[DRB]]></given-names>
</name>
<name>
<surname><![CDATA[Duarte]]></surname>
<given-names><![CDATA[MER]]></given-names>
</name>
<name>
<surname><![CDATA[Damonte]]></surname>
<given-names><![CDATA[EB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Differential inhibition of dengue virus infection in mammalian and mosquito cells by iota-carrageenan]]></article-title>
<source><![CDATA[J Gen Virol]]></source>
<year>2011</year>
<volume>92</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1332-42</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lyus]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro]]></article-title>
<source><![CDATA[Arch Pharm Res]]></source>
<year>2005</year>
<volume>28</volume>
<page-range>1293-301</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández-Romero]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Romeu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Valdés]]></surname>
<given-names><![CDATA[VS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Parra F In vitro antiviral activity of Phyllanthus orbicularis extracts against herpes simplex virus type 1]]></article-title>
<source><![CDATA[Phytother Res]]></source>
<year>2003</year>
<volume>17</volume>
<page-range>980-2</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[IT]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Stoco]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Schenkel]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Reginatto]]></surname>
<given-names><![CDATA[FH]]></given-names>
</name>
<name>
<surname><![CDATA[Simões]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro antiherpes effects of a C-glycosylflavonoid-enriched fraction of Cecropia glazioviisneth]]></article-title>
<source><![CDATA[Lett Appl Microbiol]]></source>
<year>2010</year>
<volume>51</volume>
<page-range>143-8</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zandi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Teoh]]></surname>
<given-names><![CDATA[BT]]></given-names>
</name>
<name>
<surname><![CDATA[Sam]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[PF]]></given-names>
</name>
<name>
<surname><![CDATA[Mustafa]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[and AbuBakar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2]]></article-title>
<source><![CDATA[J Med Plants Res]]></source>
<year>2011</year>
<volume>5</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>5534-9</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[ARA]]></given-names>
</name>
<name>
<surname><![CDATA[Morais]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Marques]]></surname>
<given-names><![CDATA[MMM]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[SCC]]></given-names>
</name>
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[Vieira]]></surname>
<given-names><![CDATA[IGP]]></given-names>
</name>
<name>
<surname><![CDATA[Guedes]]></surname>
<given-names><![CDATA[MIF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus]]></article-title>
<source><![CDATA[JVATiTD]]></source>
<year>2011</year>
<volume>17</volume>
<page-range>406-13</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
