<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002019000200254</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Proteasoma, subtipos y sus implicaciones en la tolerancia central]]></article-title>
<article-title xml:lang="en"><![CDATA[The proteasome: subtypes and involvement in central tolerance]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zelada Valdés]]></surname>
<given-names><![CDATA[Adrian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Ciencias Básicas y Preclínicas &#8220;Victoria de Girón&#8221; Departamento de Inmunología ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>38</volume>
<numero>2</numero>
<fpage>254</fpage>
<lpage>276</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002019000200254&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002019000200254&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002019000200254&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El proteasoma es un complejo proteico grande, el cual se encuentra fundamentalmente en todas las células eucariotas ya que juega un rol muy importante en los procesos celulares, tales como: la diferenciación celular, la progresión del ciclo celular, el desarrollo y la apoptosis celular. Existen varios tipos de proteasomas como el constitutivo, los intermedios, el inmunoproteasoma y el timoproteasoma, los cuales están presenten en las células del cuerpo en dependencia de la estructura y función de ellas. Sin embargo, se encuentran en las células del sistema inmune donde no solo juegan un papel muy importante en el procesamiento antigénico para la respuesta inmune, sino en los mecanismos de tolerancia central durante el proceso de ontogenia de los linfocitos T en el timo. Así, las células epiteliales tímicas corticales son células presentadoras de antígenos, las cuales presentan características intrínsecas únicas al presentar el timoproteasoma, la catepsina L y la proteasa serin específica del timo. Además, se ha observado una alta tasa de macroautofagia en comparación a las otras células del cuerpo, por lo que serán esenciales en la obtención de un repertorio de linfocitos T CD4+ y CD8+ que tendrán la capacidad de discriminar lo propio y lo no propio. Por lo que se debería considerar que la tolerancia central no está únicamente definida por el mecanismo de selección negativa, sino que a su vez la selección positiva juega un papel muy importante en la definición del repertorio de clones de linfocitos T no autorreactivos. El objetivo es discutir acerca del proteasoma, los tipos de proteasomas y sus implicaciones en la tolerancia central de los linfocitos T.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The proteasome is a large protein complex mainly located in all eukaryote cells, where it plays a very important role in cellular processes like differentiation, cycle progression, development and apoptosis. There are several types of proteasomes: constitutive, intermediate, immunoproteasome and thymoproteasome, which are present in cells depending on their structure and functions. However, they are found in cells of the immune system, where they play a very important role not only in antigenic processes related to the immune response, but also in central tolerance mechanisms during T lymphocyte ontogeny in the thymus. Thymic cortical epithelial cells are therefore antigen-presenting cells with unique intrinsic characteristics, since they contain thymoproteasome, cathepsin L, and thymus-specific serine protease. Additionally, a high rate of macroautophagy has been observed in comparison with bibr cells of the body. They are thus essential to obtain a repertoire of CD4+ and CD8+ T lymphocytes capable of distinguishing the body's own elements from alien structures. Therefore, central tolerance should not be viewed as only defined by the negative selection mechanism, since positive selection also plays a very important role in defining the repertoire of non-autoreactive T lymphocyte clones. The purpose of the study was to discuss the proteasome, the types of proteasomes and their involvement in T lymphocyte central tolerance.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ubiquitina]]></kwd>
<kwd lng="es"><![CDATA[proteasoma]]></kwd>
<kwd lng="es"><![CDATA[inmunoproteasoma]]></kwd>
<kwd lng="es"><![CDATA[timoproteasoma]]></kwd>
<kwd lng="es"><![CDATA[selección positiva]]></kwd>
<kwd lng="es"><![CDATA[tolerancia central]]></kwd>
<kwd lng="en"><![CDATA[ubiquitin]]></kwd>
<kwd lng="en"><![CDATA[proteasome]]></kwd>
<kwd lng="en"><![CDATA[immunoproteasome]]></kwd>
<kwd lng="en"><![CDATA[thymoproteasome]]></kwd>
<kwd lng="en"><![CDATA[positive selection]]></kwd>
<kwd lng="en"><![CDATA[central tolerance]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Hydrophobic Amino Acid Residues Are Critical for the Immunodominant Epitope of the Goodpasture Autoantigen A Molecular Basis for the Cryptic Nature of the Epitope]]></article-title>
<source><![CDATA[Journal of Biological Chemistry]]></source>
<year>2001</year>
<volume>276</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>6370-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
