<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002020000300004</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Software for cerebrospinal fluid diagnostics and statistics]]></article-title>
<article-title xml:lang="es"><![CDATA[Software para el diagnóstico y estadísticas del líquido cefalorraquídeo]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reiber]]></surname>
<given-names><![CDATA[Hansotto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Georg August Universität  ]]></institution>
<addr-line><![CDATA[Göttingen ]]></addr-line>
<country>Germany</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>39</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002020000300004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002020000300004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002020000300004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  In CSF analysis for diagnostics we have knowledge-based software for numerical and graphical data interpretation, but software programs for statistics are scarce. Free, stand-alone software programs that calculate all individual functions of CSF protein analysis and allow the statistical treatment of groups of diseases numerically and graphically are presented for relevant examples.  Methods:  Diagnosis of an intrathecal synthesis refers to the upper limit of the reference range, Qlim = Qmean +3SD, but statistical evaluation of its frequency is referred to Qmean+2SD. When quantifying intrathecal synthesis for statistics, either the absolute amount (IgGloc) or the relative intrathecal fraction (IgGIF) can be reported with reference to the mean reference curve, Qmean. The free software &#8220;CSF research Tool&#8221; for immunoglobulins allows diagnostic and statistic evaluations with Reibergrams and calculation of mean values and standard deviations from disease groups. The software &#8220;FLC-K statistics&#8221; for free light chains Kappa offers for diagnostics and statistics the numerical and graphical interpretation basis for statistical processing in exported Excel tables. A free &#8220;CSF-App&#8221; for Smartphones provides data calculation for diagnostics of single patients with examples of disease-related data patterns.  Results:  Patients with clinically isolated syndrome (CIS) who were later diagnosed as MS showed no immunological differences to patients initially diagnosed as MS (same mean quantity of intrathecal synthesis in CIS and MS detectable for IgG and FLC-K). The frequently claimed diagnostically higher sensitivity of the FLCK analysis compared to IgG, can be explained by the up to 3-fold higher mean intrathecal fraction of FLC-K, corresponding to a higher frequency in the detection of intrathecal synthesis with FLCK analysis.  Conclusions:  With a knowledge-based quantification in CSF analysis, supported by knowledge-based software programs, scientifically and diagnostically important results can be obtained.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Los programas de software gratuitos y autónomos que calculan todas las funciones individuales del análisis de proteínas del líquido cefalorraquídeo (LCR) y permiten el tratamiento estadístico de grupos de enfermedades de forma numérica y gráfica se presentan como ejemplos relevantes.  Métodos:  Cuando se cuantifica la síntesis intratecal para la estadística, se puede informar la cantidad absoluta (IgGloc) o la fracción intratecal relativa (IgGIF) con referencia a la curva de referencia media, Qmean. El software gratuito &#8220;CSF research Tool&#8221; para inmunoglobulinas permite realizar evaluaciones diagnósticas y estadísticas con Reibergrams y calcular los valores medios y las desviaciones estándar de los grupos de enfermedades. El software &#8220;FLC-K statistics&#8221; para Free light chains Kappa ofrece para el diagnóstico y la estadística la base de interpretación numérica y gráfica para el procesamiento estadístico en tablas exportadas de Excel. El programa &#8220;CSF-App&#8221; para teléfonos inteligentes es gratuito y ofrece el cálculo de datos para el diagnóstico de pacientes individuales con ejemplos de patrones de datos relacionados con enfermedades.  Resultados:  Los pacientes con síndrome clínico aislado (SCA) que posteriormente fueron diagnosticados como EM no mostraron diferencias inmunológicas con respecto a los pacientes inicialmente diagnosticados como EM (la misma cantidad media de síntesis intratecal en el síndrome clínico aislado y EM detectable para IgG y FLC-K). La sensibilidad más elevada que se afirma con frecuencia en el diagnóstico del análisis de FLC-K en comparación con la IgG, puede explicarse por la fracción intratecal media hasta tres veces mayor de FLC-K, que corresponde a una mayor frecuencia en la detección de la síntesis intratecal con el análisis de FLC-K.  Conclusiones:  Con la cuantificación en el análisis del LCR se pueden obtener resultados importantes desde el punto de vista científico y diagnóstico.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cerebrospinal fluid]]></kwd>
<kwd lng="en"><![CDATA[Statistics]]></kwd>
<kwd lng="en"><![CDATA[Software]]></kwd>
<kwd lng="en"><![CDATA[CSF-App]]></kwd>
<kwd lng="en"><![CDATA[Clinically Isolated Syndrome]]></kwd>
<kwd lng="en"><![CDATA[Multiple Sclerosis]]></kwd>
<kwd lng="en"><![CDATA[IgG]]></kwd>
<kwd lng="en"><![CDATA[Free light chains Kappa]]></kwd>
<kwd lng="es"><![CDATA[líquido cefalorraquídeo]]></kwd>
<kwd lng="es"><![CDATA[estadística]]></kwd>
<kwd lng="es"><![CDATA[software]]></kwd>
<kwd lng="es"><![CDATA[CSF-App]]></kwd>
<kwd lng="es"><![CDATA[síndrome clínico aislado]]></kwd>
<kwd lng="es"><![CDATA[esclerosis múltiple]]></kwd>
<kwd lng="es"><![CDATA[IgG]]></kwd>
<kwd lng="es"><![CDATA[cadenas ligeras libres kappa]]></kwd>
</kwd-group>
</article-meta>
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<given-names><![CDATA[B]]></given-names>
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<article-title xml:lang=""><![CDATA[The MRZ reaction as a highly specific marker of multiple sclerosis re-evaluation and structured review of the literature]]></article-title>
<source><![CDATA[J Neurol]]></source>
<year>2017</year>
<volume>264</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>453-66</page-range></nlm-citation>
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