<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002021000500021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Magnesio e indicadores bioquímicos óseo-minerales según tasa de filtración glomerular en estudiantes sin enfermedad renal]]></article-title>
<article-title xml:lang="en"><![CDATA[Magnesium and osseous-mineral biochemical indicators according to glomerular filtration rate testing in students without kidney disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brissón]]></surname>
<given-names><![CDATA[Cecilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuestas]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Denner]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prono Minella]]></surname>
<given-names><![CDATA[Priscila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bonifacino Belzarena]]></surname>
<given-names><![CDATA[Rosina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Colussi]]></surname>
<given-names><![CDATA[Vanesa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marsili]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brissón]]></surname>
<given-names><![CDATA[María Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosso]]></surname>
<given-names><![CDATA[Facundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Facultad de Bioquímica y Ciencias Biológicas Nacional del Litoral ]]></institution>
<addr-line><![CDATA[ Santa Fe]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>40</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002021000500021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002021000500021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002021000500021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La variación del magnesio y de indicadores bioquímicos del metabolismo óseo-mineral según la tasa de filtración glomerular en jóvenes sin enfermedad renal es poco conocida por lo que es necesario considerarla para delimitar lo no atribuible a enfermedad renal crónica. El papel que desempeña el magnesio está en estudio. En la enfermedad renal crónica hay una alteración progresiva del metabolismo óseo-mineral que comienza tempranamente.  Objetivos: Evaluar valores séricos de magnesio, calcio, fósforo, fosfatasa alcalina y parathormona, excreciones urinarias de 24 h y excreción fraccional de estos electrolitos según categoría G de tasa de filtración glomerular estimada por clearance de creatinina: G1 (normal a alta) y G2 (levemente disminuida) en estudiantes sin enfermedad renal crónica.  Material y métodos: Estudio analítico y corte transversal con una muestra de 55 estudiantes voluntarios sin enfermedad renal en el periodo 2018 a 2019. Los analitos se determinaron en suero y algunos en orina de 24 h.  Resultados:  Solamente magnesio sérico y excreción fraccional de magnesio excreción fraccional de magnesio mostraron diferencias significativas según la categoría G (p &lt; 0,05). Los valores de magnesio sérico magnesio sérico estuvieron dentro de los valores de referencia para el método. En G2, magnesio sérico, descendido respecto a G1 y excreción fraccional de magnesio aumentada, inversamente relacionados. El magnesio sérico disminuyó en promedio 0,26 mg/dL por unidad de aumento de excreción fraccional de magnesio (p = 0,0502).  Conclusiones: Se observaron diferencias en magnesio sérico y excreción fraccional de magnesio al comparar los resultados en G1 y G2. Los demás indicadores bioquímicos estudiados no mostraron diferencias por categoría G. Diseños de corte longitudinal en muestras mayores pueden confirmar o no estos hallazgos. Tales estudios pueden aportar a la comprensión de cambios bioquímicos del metabolismo óseo-mineral en etapas iniciales de disminución de la tasa de filtración glomerular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Not much is known about the variation in magnesium and biochemical indicators of the osseous-mineral metabolism according to glomerular filtration rate testing in young people without kidney disease. This variation should therefore be considered to delimit whatever is not attributable to chronic kidney disease. The role played by magnesium is currently under study. In chronic kidney disease a progressive alteration of the osseous-mineral metabolism starts early.  Objectives: Evaluate serum values of magnesium, calcium, phosphorus, alkaline phosphatase and parathormone, 24-hour urinary excretion and fractional excretion of these electrolytes according to category G of the glomerular filtration rate estimated by creatinine clearance: G1 (normal to high) and G2 (slightly reduced) in students without chronic kidney disease.  Methods: An analytical cross-sectional study was conducted of a sample of 55 student volunteers without kidney disease in the period 2018-2019. The analytes were determined in serum and some in 24-hour urine.  Results: Only serum magnesium and magnesium fractional excretion displayed significant differences according to category G (p &lt; 0.05). Serum magnesium values were within the reference values for the method. In G2, serum magnesium was lower than in G1, whereas magnesium fractional excretion was higher, i.e. an inverse relation is observed. Serum magnesium reduction averaged 0.26 mg/dl per unit of magnesium fractional excretion increase (p = 0.0502).  Conclusions: Comparison of G1 and G2 results revealed differences in serum magnesium and magnesium fractional excretion. The remaining biochemical indicators studied did not show any differences in category G. Longitudinal studies with larger samples may or may not confirm these findings, thus contributing to a better understanding of the biochemical changes in osseous-mineral metabolism occurring in the initial stages of glomerular filtration rate reduction.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[magnesio]]></kwd>
<kwd lng="es"><![CDATA[excreción fraccional de magnesio]]></kwd>
<kwd lng="es"><![CDATA[tasa de filtraciónglomerular]]></kwd>
<kwd lng="es"><![CDATA[enfermedad renal crónica]]></kwd>
<kwd lng="es"><![CDATA[trastorno mineral y óseo asociado a la enfermedad renal crónica]]></kwd>
<kwd lng="en"><![CDATA[magnesium]]></kwd>
<kwd lng="en"><![CDATA[magnesium fractional excretion]]></kwd>
<kwd lng="en"><![CDATA[glomerular filtration rate]]></kwd>
<kwd lng="en"><![CDATA[chronic kidney disease]]></kwd>
<kwd lng="en"><![CDATA[mineral and osseous disorder associated to chronic kidney disease]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moe]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Drueke]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Cunningham]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Goodman]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Olgaard]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: Improving Global Outcomes (KDIGO)]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2006</year>
<volume>69</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1945-53</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zou]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of klotho in chronic kidney disease]]></article-title>
<source><![CDATA[BMC Nephrol]]></source>
<year>2018</year>
<volume>19</volume>
<numero>285</numero>
<issue>285</issue>
<page-range>2-12</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pendón-Ruiz de Mier]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
<name>
<surname><![CDATA[Rodelo-Haad]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Tocados]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Muñoz-Castañeda]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Magnesium: An old player revisited in the context of CKD-MBD]]></article-title>
<source><![CDATA[ClinChim Acta]]></source>
<year>2020</year>
<volume>501</volume>
<page-range>53-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ikee]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions]]></article-title>
<source><![CDATA[Ren Replace Ther]]></source>
<year>2018</year>
<volume>4</volume>
<page-range>1</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<collab>Kidney Disease: Improving Global Outcomes (KDIGO) CKD WorkGroup</collab>
<article-title xml:lang=""><![CDATA[KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease]]></article-title>
<source><![CDATA[Kidney Int Suppl]]></source>
<year>2013</year>
<volume>3</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-150</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Levey]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Eckardt]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Dorman]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Christiansen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hoorn]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Ingelfinger]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nomenclature for kidney function and disease: report of a kidney disease: improving global outcomes (KDIGO) consensus conference]]></article-title>
<source><![CDATA[KidneyInt]]></source>
<year>2020</year>
<volume>97</volume>
<page-range>1117-29</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lujan Ramos]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez Arce]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Acevedo Romero]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez Jiménez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cañas Osorio]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Santander Bohorquez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia de las alteraciones del metabolismo oseo-mineral asociadas a enfermedad renal crónica no en diálisis]]></article-title>
<source><![CDATA[Rev. Colomb. Nefrol]]></source>
<year>2019</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>17-27</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Craver]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Marco]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Rue]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Borràs]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Martín]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mineral metabolism parameters throughout chronic kidney disease stages 1-5--achievement of K/DOQI target ranges]]></article-title>
<source><![CDATA[Nephrol Dial Transplant]]></source>
<year>2007</year>
<numero>4</numero>
<issue>4</issue>
<page-range>1171-6</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hsiao]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Liao]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Kao]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chuu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of fractional excretion of electrolytes in patients at different stages of chronic kidney disease]]></article-title>
<source><![CDATA[Medicine (Baltimore)]]></source>
<year>2020</year>
<volume>99</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferrè]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Adams-Huet]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Maalouf]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Sakhaee]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Toto]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low serum magnesium is associated with faster decline in kidney function: the Dallas Heart Study experience]]></article-title>
<source><![CDATA[J Investig Med]]></source>
<year>2019</year>
<volume>67</volume>
<page-range>987-94</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Grams]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Maruthur]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Astor]]></surname>
<given-names><![CDATA[BC]]></given-names>
</name>
<name>
<surname><![CDATA[Couper]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Mosley]]></surname>
<given-names><![CDATA[TH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Results from the atherosclerosis risk in communities study suggest that low serum magnesium is associated with incident kidney disease]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2015</year>
<volume>87</volume>
<page-range>820-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Joosten]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Gansevoort]]></surname>
<given-names><![CDATA[RT]]></given-names>
</name>
<name>
<surname><![CDATA[Bakker]]></surname>
<given-names><![CDATA[SJL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low plasma magnesium and risk of developing chronic kidney disease: results from the PREVEND Study]]></article-title>
<source><![CDATA[KidneyInt]]></source>
<year>2015</year>
<volume>87</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1262-3</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
