<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192018000800755</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectividad del Vimang® en pacientes con lesión hepática a causa del virus del dengue]]></article-title>
<article-title xml:lang="en"><![CDATA[Effectiveness of the Vimang® in patients with liver damage due to dengue virus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Valle Díaz]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piñera Martínez]]></surname>
<given-names><![CDATA[Marjoris]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betancourt Hechavarría]]></surname>
<given-names><![CDATA[Frank Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Valle Piñera]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Valle Piñera]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Provincial Docente Clinicoquirúrgico &#8220;Saturnino Lora Torres&#8221; ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas Facultad de Medicina No. 1 ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>8</numero>
<fpage>755</fpage>
<lpage>769</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192018000800755&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192018000800755&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192018000800755&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  En la evolución de la infección por el virus de dengue es frecuente la aparición de la lesión hepática, lo cual se asocia con el estrés oxidativo.  Objetivo:  Demostrar la efectividad del concentrado de Vimang® en pacientes con diagnóstico de lesión hepática por virus del dengue.  Métodos:  Se efectuó un ensayo clínico en fase III, abierto y aleatorizado, en la consulta de Hepatología del Hospital Provincial Docente Clinicoquirúrgico &#8220;Saturnino Lora Torres&#8221; de Santiago de Cuba, desde junio del 2014 hasta igual mes del 2017, consistente en la aplicación del concentrado de Vimang® en 39 pacientes con hepatitis reactiva por dengue, que conformaron el grupo de estudio, para luego comparar los resultados con los del grupo de control, integrado por igual número de pacientes con la afección, en quienes solo se aplicaron las medidas higiénico-dietéticas habituales.  Resultados:  En la serie se obtuvo un descenso importante de los valores medios de las pruebas para evaluar la función hepática en ambos grupos de trabajo, pero fueron más significativos en los pacientes que recibieron Vimang®. Del mismo modo, a los 9 meses se apreció una mejoría en 89,0 % de los casos en cuanto a la disminución de los síntomas, frente a tan solo 69,2 % de los controles. La hepatomegalia, como signo físico más importante, desapareció en el total de los casos al año de seguimiento clínico; sin embargo, se mantuvo en 7,2 % del grupo de control.  Conclusiones:  Pudo demostrarse que el Vimang® influye de manera importante en el control de los síntomas y en la mejoría humoral de los pacientes que presentan lesión hepática ocasionada por el dengue.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The emergence of the liver damage is frequent in the clinical course of the infection due to the dengue virus, which is associated to the oxidative stress.  Objective:  To demonstrate the effectiveness of the Vimang® concentrate in patients with diagnosis of liver damage due to dengue virus.  Methods:  A clinical open and randomized assay in phase III was carried out, in the Hepathology department of "Saturnino Lora Torres" Teaching Provincial Clinical Surgical Hospital in Santiago de Cuba, from June, 2014 to the same month in 2017, consistent in the use of Vimang® concentrate in 39 patients with reactive hepatitis due to dengue fever, who formed the study group, and then the results were compared with those of the control group, integrated by equally number of patients with the affection, in whom the habitual hygienic-dietary measures were applied.  Results:  In the series an important decrease of the mean values of the tests was obtained to evaluate the hepatic function in both groups, but they were more significant in the patients who received Vimang®. In the same way, an improvement was appreciated after 9 months in 89.0 % of the cases as for the decrease of the symptoms, compared to a 69.2 % of the controls. Hepatomegaly, as the most important physical sign, disappeared in the total of the cases after a year of clinical follow-up; however, it remained in 7.2 % of the control group.  Conclusions:  It could be demonstrated that Vimang® influences in a significant way in the control of the symptoms and in the humoral improvement of the patients who present liver damage caused by dengue fever.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Vimang®]]></kwd>
<kwd lng="es"><![CDATA[hepatitis reactiva]]></kwd>
<kwd lng="es"><![CDATA[estrés oxidativo]]></kwd>
<kwd lng="es"><![CDATA[virus del dengue]]></kwd>
<kwd lng="en"><![CDATA[Vimang®]]></kwd>
<kwd lng="en"><![CDATA[reactive hepatitis]]></kwd>
<kwd lng="en"><![CDATA[oxidative stress]]></kwd>
<kwd lng="en"><![CDATA[dengue virus]]></kwd>
</kwd-group>
</article-meta>
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