<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-8120</journal-id>
<journal-title><![CDATA[Humanidades Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Hum Med]]></abbrev-journal-title>
<issn>1727-8120</issn>
<publisher>
<publisher-name><![CDATA[Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-81202023000200007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Consideraciones bioéticas sobre los incentivos a participantes voluntarios sanos en investigaciones Fase I]]></article-title>
<article-title xml:lang="en"><![CDATA[Bioethical considerations on incentives for healthy volunteer participants in Phase I Research]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casas Martínez]]></surname>
<given-names><![CDATA[María de la Luz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Panamericana Centro Interdisciplinario de Bioética ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>23</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-81202023000200007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-81202023000200007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-81202023000200007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los ensayos clínicos en Fase I se realzan con la participación de voluntarios sanos de prueban la seguridad y tolerabilidad de los productos farmacéuticos en investigación. En ellos, los participantes están expuestos a riesgos de medicamentos del estudio sin la posibilidad de un beneficio médico directo y, por lo general, deben pasar días o semanas en un centro de investigación. Los incentivos, como pagos monetarios se utilizan para incentivar la inscripción y compensar a los participantes por su tiempo. Estas características de los ensayos voluntarios sanos de fase I crean un contexto de investigación que difiere notablemente de la mayoría de las otras investigaciones clínicas, pues la mayoría de ellos son personas vulnerables económicamente. Este artículo presenta el objetivo de analizar factores bioéticos que inciden en el otorgamiento de incentivos a participantes voluntarios sanos en investigaciones Fase I.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Phase I Clinical Trials are conducted with the participation of healthy volunteers to test the safety and tolerability of pharmaceutical products. In them, participants are exposed to study drug risks without the possibility of direct medical benefit and usually must spend days or weeks at a research site. Incentives such as monetary payments are used to encourage enrollment and compensate participants for their time. These characteristics of Phase I healthy volunteer trials create a research context that differs markedly from most other clinical research, as most of them are financially vulnerable individuals. This paper aims to analyze bioethical factors that influence the granting of incentives to healthy volunteer participants in Phase I research.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[investigación]]></kwd>
<kwd lng="es"><![CDATA[sujetos sanos]]></kwd>
<kwd lng="es"><![CDATA[ensayos clínicos fase I]]></kwd>
<kwd lng="es"><![CDATA[bioética]]></kwd>
<kwd lng="en"><![CDATA[research]]></kwd>
<kwd lng="en"><![CDATA[healthy volunteers]]></kwd>
<kwd lng="en"><![CDATA[Phase I clinical trials]]></kwd>
<kwd lng="en"><![CDATA[bioethics]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA['My Body Is One of the Best Commodities': Exploring the Ethics of Commodification in Phase I Healthy Volunteer Clinical Trials]]></article-title>
<source><![CDATA[Kennedy Institute of Ethics Journal]]></source>
<year>2019</year>
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