<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-897X</journal-id>
<journal-title><![CDATA[MediSur]]></journal-title>
<abbrev-journal-title><![CDATA[Medisur]]></abbrev-journal-title>
<issn>1727-897X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas, Provincia de Cienfuegos.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-897X2021000100157</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectividad de Cucurbita pepo en el tratamiento de la hiperplasia prostática. Revisión sistemática y meta-análisis]]></article-title>
<article-title xml:lang="en"><![CDATA[Effectiveness of Cucurbita pepo in the prostatic hyperplasia treatment. Systematic review and meta-analysis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila Cabreja]]></surname>
<given-names><![CDATA[José Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Méndez]]></surname>
<given-names><![CDATA[Felicia María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Venegas]]></surname>
<given-names><![CDATA[Elia de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña Velázquez]]></surname>
<given-names><![CDATA[Adolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Facultad de Ciencias Médicas Manuel Fajardo  ]]></institution>
<addr-line><![CDATA[La Habana La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Facultad de Ciencias Médicas Finlay Albarrán  ]]></institution>
<addr-line><![CDATA[La Habana La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2021</year>
</pub-date>
<volume>19</volume>
<numero>1</numero>
<fpage>157</fpage>
<lpage>165</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-897X2021000100157&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-897X2021000100157&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-897X2021000100157&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  La hiperplasia prostática benigna es el tumor benigno más frecuente en hombres. El aceite extraído de la semilla de calabaza (Curcubita pepo) se emplea en el tratamiento de los síntomas asociados a dicha enfermedad. Sin embargo, los estudios en humanos son escasos, y la evidencia disponible, insuficiente.  Objetivos:  determinar la efectividad de la semilla de calabaza en el tratamiento de la hiperplasia prostática benigna realizar revisión sistemática y meta-análisis.  Métodos:  se realizó revisión sistemática y meta-análisis, de la literatura existente en las bases de datos Pubmed/Medline, Ebsco, Scopus y Scielo. Fueron seleccionados los ensayos clínicos aleatorizados, en cualquier idioma, que evaluaron la efectividad de fitomedicamentos compuestos por la Cucurbita pepo, comparándolo con un placebo; en pacientes con diagnóstico de hiperplasia prostática comprobado; y con un tiempo de evaluación mayor a seis meses.  Resultados:  la población total estudiada en los estudios seleccionados fue de 1403 hombres, todos mayores de 50 años. Todos los estudios evaluaron la efectividad del aceite de la semilla de calabaza. La diferencia de medias global fue significativa (DM: -0,76 IC 95%: -1,40; -0,13; I  2 =26,75 %). No se encontró una mejoría significativa en cuanto a la calidad de vida, parámetros uroflujométricos, volumen residual, valores del antígeno prostático de superficie y el tamaño de la próstata.  Conclusión:  Los resultados mostraron, con un nivel de evidencia moderado, que los fitomedicamentos basados en la semilla de calabaza o su extracto no se asoció con una mejoría clínica ni funcional de la hiperplasia prostática benigna.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Benign prostatic hyperplasia is the most common benign tumor in men. The oil extracted from the pumpkin seed (Curcubita pepo) is used to treat the symptoms associated with this disease. However, human studies are few, and insufficient available evidence.  Objectives:  to determine the effectiveness of pumpkin seed in the treatment of benign prostatic hyperplasia. To carry out a systematic review and meta-analysis on it.  Methods:  a systematic review and meta-analysis of the existing literature in the Pubmed / Medline, Ebsco, Scopus and Scielo databases were carried out. Randomized clinical trials were selected, in any language that evaluated the effectiveness of phytomedicines composed of Cucurbita pepo, comparing it with a placebo; in patients with a proven diagnosis of prostatic hyperplasia; and with an evaluation time greater than six months.  Results:  the total population in the selected studies was 1403 men, all over 50 years of age. All studies evaluated the effectiveness of pumpkin seed oil. The global mean difference was significant (MD: -0.76 95% CI: -1.40, -0.13, I2 = 26.75%). No significant improvement was found in terms of quality of life, uroflowmetric parameters, residual volume, prostate surface antigen values, and prostate size.  Conclusion:  The results showed, with a moderate level of evidence, that phytomedicines based on pumpkin seed or its extract were not associated with a clinical or functional improvement of benign prostatic hyperplasia.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hyperplasia prostática]]></kwd>
<kwd lng="es"><![CDATA[cucurbita]]></kwd>
<kwd lng="es"><![CDATA[ensayos clínicos como asunto]]></kwd>
<kwd lng="en"><![CDATA[Prostatic hyperplasia]]></kwd>
<kwd lng="en"><![CDATA[cucurbita]]></kwd>
<kwd lng="en"><![CDATA[clinical trials as topic]]></kwd>
</kwd-group>
</article-meta>
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