<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2020000400002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Comorbilidades y gravedad clínica de la COVID-19: revisión sistemática y meta-análisis]]></article-title>
<article-title xml:lang="en"><![CDATA[Comorbidities and clinical severity of COVID-19: systematic review and meta-analysis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Plasencia-Urizarri]]></surname>
<given-names><![CDATA[Thais M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilera-Rodríguez]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Almaguer-Mederos]]></surname>
<given-names><![CDATA[Luis E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Universitario &#8220;Vladimir Ilich Lenin&#8221;  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro para la Investigación y Rehabilitación de Ataxias Hereditarias  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Holguín  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>19</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2020000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2020000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2020000400002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La emergencia de la COVID-19 se ha convertido en un serio problema de salud a nivel mundial. La identificación de comorbilidades asociadas a la presentación clínica grave de la COVID-19, es de importancia para el adecuado abordaje terapéutico de los pacientes afectados.  Objetivo: Evaluar el riesgo de COVID-19 con presentación clínica grave en pacientes con comorbilidades.  Material y métodos:  Se realizó una revisión sistemática y meta-análisis en bases de datos especializadas en busca de artículos publicados hasta el 20 de marzo de 2020, que aportaran información sobre la asociación entre la gravedad de la presentación clínica de la COVID-19 y comorbilidades. Se empleó la razón de probabilidades con un intervalo de confianza de 95 %, y modelos de efectos fijos o aleatorios.  Resultados:  En el análisis fueron incluidos 13 estudios para un total de 99 817 pacientes. Se obtuvieron los efectos globales para la hipertensión arterial (RP: 4,05; IC 95 %: 3,45-4,74), enfermedad cardiovascular (RP: 4,39; IC 95 %: 3,29-5,87), Diabetes Mellitus (RP: 3,53; IC 95 %: 2,79-4,47), hábito de fumar (RP: 2,87; IC 95 %: 1,81-4,54), enfermedades respiratoria (RP: 2,73; IC 95 %: 2,55-2,94), renal (RP: 5,60; IC 95 %: 4,13-7,60) y hepática crónicas (RP: 1,98 (IC 95 %: 1,08-3,64) e inmunodeficiencias (RP: 2,90; IC 95 %: 2,06-4,09), en pacientes graves en comparación con pacientes no graves.  Conclusiones: La enfermedad renal crónica, la enfermedad cardiovascular, la hipertensión arterial y la Diabetes Mellitus están entre las comorbilidades que mayor riesgo implican para una presentación clínica grave en pacientes con COVID-19, seguidas en importancia por las inmunodeficiencias, hábito de fumar, enfermedad respiratoria crónica y enfermedad hepática crónica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The recent emergence of COVID-19 has become a serious global health problem. The identification of comorbidities associated with the clinical severity in COVID-19 patients is of paramount significance for the appropriate therapeutic approach of affected patients.  Objective:  To evaluate the risk of severe clinical presentation of COVID-19 in patients with comorbidities.  Materials and methods: A systematic literature search and meta-analysis was conducted in specialized databases to obtain information from articles published until March 20, 2020. All relevant papers with information on the association between clinical severity and comorbidities were included. The odds ratio with 95 % confidence interval and fixed or random effect models were used.  Results: Thirteen studies were included for a total of 99 817 patients. Global effects were obtained for hypertension (OR: 4.05; 95 % CI: 3.45-4.74), cardiovascular disease (OR: 4.39; 95 % CI: 3.29-5.87), diabetes mellitus (OR: 3.53; 95 % CI: 2.79-4.47), smoking (OR: 2.87; 95 % CI: 1.81-4.54), chronic lung disease (OR: 2.73; 95 % CI: 2.55-2.94), chronic kidney disease (OR: 5.60; 95 % CI: 4.13-7.60), chronic liver disease (OR: 1.98; 95 % CI: 1.08-3.64), and immunodeficiency (OR: 2.90; 95 % CI: 2.06-4.09) in severe patients compared with non-severe patients.  Conclusions: Chronic kidney disease, cardiovascular disease, hypertension and diabetes are among the comorbidities with the highest risk of severe clinical presentation in COVID-19 patients, followed in importance by immunodeficiency, smoking, chronic lung disease and chronic liver disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Comorbilidades]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[gravedad clínica]]></kwd>
<kwd lng="es"><![CDATA[meta-análisis]]></kwd>
<kwd lng="en"><![CDATA[Comorbidities]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[clinical severity]]></kwd>
<kwd lng="en"><![CDATA[meta-analysis]]></kwd>
</kwd-group>
</article-meta>
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