<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2079-3480</journal-id>
<journal-title><![CDATA[Cuban Journal of Agricultural Science]]></journal-title>
<abbrev-journal-title><![CDATA[Cuban J. Agric. Sci.]]></abbrev-journal-title>
<issn>2079-3480</issn>
<publisher>
<publisher-name><![CDATA[Editorial del Instituto de Ciencia Animal]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2079-34802020000200243</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Evaluation of the antioxidant and hepatoprotective activity of Mucuna pruriens (L) cv. utilis forage meal and their polyphenols extract in Sprague Dowley rats]]></article-title>
<article-title xml:lang="es"><![CDATA[Evaluación de la actividad antioxidante y hepatoprotectora de la harina de forraje de Mucuna pruriens (L) vc. utilis y su extracto de polifenoles en ratas Sprague Dowley]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Scull Rodríguez]]></surname>
<given-names><![CDATA[Idania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Savón Valdés]]></surname>
<given-names><![CDATA[Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spengler Salabarria]]></surname>
<given-names><![CDATA[Iraida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera Villafranca]]></surname>
<given-names><![CDATA[Magaly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Ciencia Animal Dpto. Monogástrico ]]></institution>
<addr-line><![CDATA[San José de las Lajas Mayabeque]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de La Habana Facultad de Química Centro de Estudios de Productos Naturales]]></institution>
<addr-line><![CDATA[ Cuidad de La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>54</volume>
<numero>2</numero>
<fpage>243</fpage>
<lpage>255</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2079-34802020000200243&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2079-34802020000200243&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2079-34802020000200243&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In order to evaluate the antioxidant and hepatoprotective effect of Mucuna pruriens (L) cv. utilis forage meal and their polyphenol extract, an intoxication model induced with carbon tetrachloride (CCl4) was used. A total of 60 Sprague Dowley rats from both sex of 7-8 weeks of age were used, distributed in three treatments, according to a completely random design. The treatments consisted in a control group with EAO-1004 diet, which contained the premixture with antioxidants, and two experimental groups, which was supplied the Mucuna pruriens forage meal and their polyphenol extract, in a dose of 300 mg/kg body weight respectively, in replacement of the control diet premixture. All groups received the diet of their treatments and water ad libitum. At the end of the experimental period (30d), the animals were slaughtered and biochemical blood indicators were studied, the alanine aminotransferase (ALT) and the aspartate aminotransferase (AST) enzymes were quantified. The activity of the catalase antioxidant enzyme and the antioxidant state of the animals were also determined. The increase of the catalase enzyme concentration in liver (10.42 UI/L) and blood serum (20.50 UI/L) showed that the meal and their extract change the redox state caused by the CCl4.The forage meal and their polyphenols extract showed its hepatoprotective effect against the damage action of the CCl4,evaluated by the alanine aminotransferase and aspartate aminotransferase. The results showed that it is possible to use, in diets for rats the forage meal and their polyphenols extract with antioxidants effects similar to those of the control diet, which used synthetic antioxidants, vitamins and minerals. It is suggested to developed similar studies in productive animals, that includes studies of doses optimization for different animal categories.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Para evaluar el efecto antioxidante y hepatoprotector de la harina de forraje de Mucuna pruriens (L) vc. utilis y su extracto de polifenoles, se utilizó un modelo de intoxicación inducida con tetracloruro de carbono (CCl4). Se emplearon 60 ratas Sprague Dowley de ambos sexos, de 7-8 semanas de edad, distribuidas en tres tratamientos, según diseño completamente aleatorizado. Los tratamientos consistieron en un grupo control con dieta EAO-1004, que contenía la premezcla con los antioxidantes, y dos grupos experimentales, a los que se les suministró la harina de forraje de Mucuna pruriens y su extracto de polifenoles, en una dosis de 300 mg/kg de peso corporal respectivamente, en sustitución de la premezcla de la dieta control. Todos los grupos recibieron la dieta de sus respectivos tratamientos y el agua ad libitum. Al término del período experimental (30 d), los animales se sacrificaron y se estudiaron indicadores de la bioquímica sanguínea, se cuantificaron las enzimas alanino aminotrasferasa (ALT) y el aspartato aminotransferasa (AST). También se determinó la actividad de la enzima antioxidante catalasa y el estatus antioxidante de los animales. El incremento de la concentración de la enzima catalasa en hígado (10.42 UI/L) y suero (20.50 UI/L) indicó que la harina y su extracto transformaron el estado redox producido por el CCl4. La harina de forraje y su extracto de polifenoles mostraron su efecto hepatoprotector ante la acción nociva del CCl4, evaluado por la alanino aminotrasferasa y aspartato aminotransferasa. Los resultados señalan que es posible utilizar en la dieta de las ratas la harina de forraje y su extracto de polifenoles con efectos antioxidantes similares a los que manifiesta la dieta control, que utiliza antioxidantes sintéticos, vitaminas y minerales. Se sugiere desarrollar en animales productivos estudios similares, que incluyan trabajos de optimización de dosis para diferentes categorías de animales.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[oxidative stress]]></kwd>
<kwd lng="en"><![CDATA[serum polyphenols]]></kwd>
<kwd lng="en"><![CDATA[catalase]]></kwd>
<kwd lng="en"><![CDATA[aspartate aminotransferase]]></kwd>
<kwd lng="es"><![CDATA[estrés oxidativo]]></kwd>
<kwd lng="es"><![CDATA[polifenoles séricos]]></kwd>
<kwd lng="es"><![CDATA[catalasa]]></kwd>
<kwd lng="es"><![CDATA[aspartato aminotransferasa]]></kwd>
</kwd-group>
</article-meta>
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