<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2434</journal-id>
<journal-title><![CDATA[Revista Finlay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Finlay]]></abbrev-journal-title>
<issn>2221-2434</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos. Centro Provincial de información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24342022000200144</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Marcadores bioquímicos de aterosclerosis subclínica en pacientes con diabetes mellitus tipo 2]]></article-title>
<article-title xml:lang="en"><![CDATA[Biochemical Markers of Subclinical Atherosclerosis in Patients with Type 2 Diabetes Mellitus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Osorio Sosa]]></surname>
<given-names><![CDATA[Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nápoles Acosta]]></surname>
<given-names><![CDATA[Leonar Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vallés Gamboa]]></surname>
<given-names><![CDATA[Alfredo Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caballero Laguna]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Docente Guillermo Domínguez López  ]]></institution>
<addr-line><![CDATA[Las Tunas ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>12</volume>
<numero>2</numero>
<fpage>144</fpage>
<lpage>150</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24342022000200144&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24342022000200144&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24342022000200144&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  la resistencia a la insulina y las alteraciones metabólicas asociadas, como la dislipemia, la hipertensión, la obesidad y la hipercoagulabilidad, influyen en la aparición cada vez más prematura y la severidad de la aterosclerosis que desarrollan los pacientes con diabetes mellitus  Objetivo:  evaluar los marcadores bioquímicos de aterosclerosis subclínica en pacientes con diabetes mellitus tipo 2.  Método:  se realizó un estudio descriptivo y transversal para evaluar marcadores bioquímicos de aterosclerosis subclínica en 100 pacientes con diabetes mellitus tipo 2 atendidos en el Hospital General Docente Guillermo Domínguez López desde abril del 2020 hasta marzo del 2021. Las variables analizadas fueron: edad, sexo, tensión arterial, antecedentes patológicos personales de diabetes mellitus, hábitos tóxicos y riesgo cardiovascular. Estos pacientes fueron clasificados según su riesgo cardiovascular global utilizando las gráficas de riesgo que establece la Organización Mundial de la Salud para la región de las Américas y se les realizaron las determinaciones de colesterol total, triglicéridos, LDL colesterol, HDL colesterol, creatinina, ácido úrico, cistatina C, fibrinógeno, proteína C reactiva de alta sensibilidad. La información se procesó mediante métodos de estadística descriptiva, principalmente tasas y porcientos.  Resultados:  la mayoría de los pacientes se clasificaron en riesgo cardiovascular global 2 y 3. Sus marcadores mostraron asociación con las categorías de riesgo establecidas en cada paciente. Las determinaciones de triglicéridos, HDL-colesterol y ácido úrico fueron las más significativas para identificar el daño vascular en los pacientes con diabetes mellitus tipo 2.  Conclusiones:  hubo una relación directa entre los valores alterados de la proteína C reactiva de alta sensibilidad y el riesgo cardiovascular global en los pacientes estudiados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  insulin resistance and associated metabolic alterations, such as dyslipidemia, hypertension, obesity and hypercoagulability, influence the increasingly premature appearance and severity of atherosclerosis that patients with diabetes mellitus develop.  Objective:  to evaluate the biochemical markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus.  Method:  a descriptive and cross-sectional study was carried out to evaluate biochemical markers of subclinical atherosclerosis in 100 patients with type 2 diabetes mellitus treated at the Guillermo Dominguez López General Teaching Hospital from April 2020 to March 2021. The used variables were: age, sex, blood pressure, personal medical history of diabetes mellitus, toxic habits and cardiovascular risk. These patients were classified according to their global cardiovascular risk using the risk charts established by the World Health Organization for the Americas region and total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, creatinine, uric acid determinations were performed, cystatin C, fibrinogen, high-sensitivity C-reactive protein. The information was processed using descriptive statistics methods, mainly rates and percentages.  Results:  most of the patients were classified in global cardiovascular risk 2 and 3. Their markers showed association with the risk categories established in each patient. The determinations of triglycerides, HDL-cholesterol and uric acid were the most significant to identify vascular damage in patients with type 2 diabetes mellitus.  Conclusions:  there was a direct relationship between altered values &#8203;&#8203;of high-sensitivity C-reactive protein and global cardiovascular risk in the studied patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[aterosclerosis]]></kwd>
<kwd lng="es"><![CDATA[marcadores bioquímicos]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus tipo 2]]></kwd>
<kwd lng="en"><![CDATA[atherosclerosis]]></kwd>
<kwd lng="en"><![CDATA[biochemical markers]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus type 2]]></kwd>
</kwd-group>
</article-meta>
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