<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212019000300371</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Reductive amination of 4,5-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde derived from aloe-emodin]]></article-title>
<article-title xml:lang="es"><![CDATA[Aminación reductiva del 4,5-dimetoxi-9,10-dioxo-9,10-dihidroantraceno-2-carbaldehído derivado de aloe-emodin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Molina]]></surname>
<given-names><![CDATA[Yennys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Verniest]]></surname>
<given-names><![CDATA[Guido]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casals-Hung]]></surname>
<given-names><![CDATA[Magaly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acevedo-Martínez]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Oriente Faculty of Natural and Exact Sciences Department of Chemistry]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Vrije Universiteit Brussel (VUB) Faculty of Science and Bio-Engineering Sciences Research Group of Organic Chemistry, Department of Chemistry and Department of Bio-Engineering Sciences]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Belgium</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>31</volume>
<numero>3</numero>
<fpage>371</fpage>
<lpage>387</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212019000300371&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212019000300371&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212019000300371&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The reductive amination of the 1,8-O-protected aloe-emodin carbaldehyde to obtain amino derivatives using different reducing agents and conditions is reported in this article. Aldehyde was obtained in good yield using manganese dioxide as oxidizing agent. The synthesis of two new imines derived from 1,8-O-dimethyl aloe-emodin carbaldehyde is reported as wellin good yields. Sodium borohydride in methanolgave the best conversions as reducing agent for the reductive amination and the conditions were adjusted to increase the conversion to 59 % of the desired product. Same results were obtained starting from the aldehyde or from the imine, in a stepwise or an indirect reductive amination respectively.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La aminación reductiva para obtener aminas derivadas del carbaldehído del aloe-emodin 1,8-O-protegido empleando diferentes condiciones y agentes reductores es reportada en este artículo. El aldehído fue obtenido con buen rendimiento usando dióxido de manganeso como agente oxidante. De igual manera, se reporta la síntesis de nuevas iminas derivadas de dicho aldehído con buenos rendimientos. Usando borohidruro de sodio en metanol, como agente reductor para la aminación reductiva, se obtuvieron los mejores resultados y las condiciones fueron ajustadas para incrementar el porciento de conversión hasta un 59 % del producto deseado. Se obtuvieron los mismos resultados partiendo del aldehído o de la imina, usando el procedimiento indirecto o paso a paso, respectivamente.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[aloe-emodin]]></kwd>
<kwd lng="en"><![CDATA[reductive amination]]></kwd>
<kwd lng="en"><![CDATA[imine]]></kwd>
<kwd lng="en"><![CDATA[amine]]></kwd>
<kwd lng="en"><![CDATA[sodium borohydride]]></kwd>
<kwd lng="es"><![CDATA[aloe-emodin]]></kwd>
<kwd lng="es"><![CDATA[aminación reductiva]]></kwd>
<kwd lng="es"><![CDATA[imina]]></kwd>
<kwd lng="es"><![CDATA[amina]]></kwd>
<kwd lng="es"><![CDATA[borohidruro de sodio]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CARCASONA]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[GRIMMINGER]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[HIETALA]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[ZAESKE]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[WITTHOHN]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Method of preparing Diacetyl Rhein]]></source>
<year>1995</year>
<month>-0</month>
<day>2-</day>
<publisher-loc><![CDATA[Germany ]]></publisher-loc>
<publisher-name><![CDATA[Madaus AG]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MITSCHER]]></surname>
<given-names><![CDATA[L. A]]></given-names>
</name>
</person-group>
<source><![CDATA[Anthracycline synthesis]]></source>
<year>1980</year>
<month>-0</month>
<day>7-</day>
<publisher-loc><![CDATA[USA ]]></publisher-loc>
<publisher-name><![CDATA[University of Kansas Endowment Association]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[LIN]]></surname>
<given-names><![CDATA[H.-D.]]></given-names>
</name>
<name>
<surname><![CDATA[LI]]></surname>
<given-names><![CDATA[K.-T.]]></given-names>
</name>
<name>
<surname><![CDATA[DUAN]]></surname>
<given-names><![CDATA[Q.-Q.]]></given-names>
</name>
<name>
<surname><![CDATA[CHEN]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[TIAN]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[CHU]]></surname>
<given-names><![CDATA[E. S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[BAI]]></surname>
<given-names><![CDATA[D.-Q]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study]]></article-title>
<source><![CDATA[Oncology Lett]]></source>
<year>2017</year>
<volume>13</volume>
<page-range>3431-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CHANG]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[ZHAO]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[TIAN]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[JIANG]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[LU]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[MA]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[ZHANG]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[JIN]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[DONG]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[LIU]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[DONG]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation]]></article-title>
<source><![CDATA[Oncology Lett]]></source>
<year>2016</year>
<volume>12</volume>
<page-range>2232-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[THIMMEGOWDA]]></surname>
<given-names><![CDATA[N. R.]]></given-names>
</name>
<name>
<surname><![CDATA[PARK]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[SHWETHA]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[SAKCHAISRI]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[LIU]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[HWANG]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[LEE]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[JEONG]]></surname>
<given-names><![CDATA[S. J.]]></given-names>
</name>
<name>
<surname><![CDATA[SOUNG]]></surname>
<given-names><![CDATA[N. K.]]></given-names>
</name>
<name>
<surname><![CDATA[JANG]]></surname>
<given-names><![CDATA[J. H.]]></given-names>
</name>
<name>
<surname><![CDATA[RYOO]]></surname>
<given-names><![CDATA[I.-J.]]></given-names>
</name>
<name>
<surname><![CDATA[AHN]]></surname>
<given-names><![CDATA[J. S.]]></given-names>
</name>
<name>
<surname><![CDATA[ERIKSON]]></surname>
<given-names><![CDATA[R. L.]]></given-names>
</name>
<name>
<surname><![CDATA[KIM]]></surname>
<given-names><![CDATA[B. Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives]]></article-title>
<source><![CDATA[Chem Biol Drug Des]]></source>
<year>2015</year>
<volume>85</volume>
<page-range>638-44</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[YAO]]></surname>
<given-names><![CDATA[G.-Y.]]></given-names>
</name>
<name>
<surname><![CDATA[YE]]></surname>
<given-names><![CDATA[M.-Y.]]></given-names>
</name>
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[R.-Z.]]></given-names>
</name>
<name>
<surname><![CDATA[LI]]></surname>
<given-names><![CDATA[Y.-J.]]></given-names>
</name>
<name>
<surname><![CDATA[PAN]]></surname>
<given-names><![CDATA[Y.-M.]]></given-names>
</name>
<name>
<surname><![CDATA[XU]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[LIAO]]></surname>
<given-names><![CDATA[Z.-X.]]></given-names>
</name>
<name>
<surname><![CDATA[WANG]]></surname>
<given-names><![CDATA[H.-S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synthesis and antitumor activities of novel rhein a-aminophosphonates conjugates]]></article-title>
<source><![CDATA[Bioorg Med Chem Lett]]></source>
<year>2014</year>
<volume>24</volume>
<page-range>501-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[P.-H.]]></given-names>
</name>
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[C.-Y.]]></given-names>
</name>
<name>
<surname><![CDATA[CHEN]]></surname>
<given-names><![CDATA[M.-C.]]></given-names>
</name>
<name>
<surname><![CDATA[LEE]]></surname>
<given-names><![CDATA[Y.-T.]]></given-names>
</name>
<name>
<surname><![CDATA[YUE]]></surname>
<given-names><![CDATA[C.-H.]]></given-names>
</name>
<name>
<surname><![CDATA[WANG]]></surname>
<given-names><![CDATA[H.-Y.]]></given-names>
</name>
<name>
<surname><![CDATA[LIN]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ERa Inhibition]]></article-title>
<source><![CDATA[Evidence-Based Complementary and Alternative Medicine]]></source>
<year>2013</year>
<volume>2013</volume>
<page-range>376123</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[YANG]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[SUN]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[YANG]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[WANG]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel Rhein Analogues as Potential Anticancer Agents]]></article-title>
<source><![CDATA[Chem Med Chem]]></source>
<year>2011</year>
<volume>6</volume>
<page-range>2294-301</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[PECERE]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[GAZZOLA]]></surname>
<given-names><![CDATA[M. V.]]></given-names>
</name>
<name>
<surname><![CDATA[MUCIGNAT]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[PAROLIN]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[VECCHIA]]></surname>
<given-names><![CDATA[F. D.]]></given-names>
</name>
<name>
<surname><![CDATA[CAVAGGIONI]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[BASSO]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[DIASPRO]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[SALVATO]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[CARLI]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[PALÙ]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aloe-emodin Is a New Type of Anticancer Agent with Selective Activity against Neuroectodermal Tumors]]></article-title>
<source><![CDATA[Cancer Res]]></source>
<year>2000</year>
<volume>60</volume>
<page-range>2800-4</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DIVYA]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[PANONNUMMAL]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[GUPTA]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[JAYAKUMAR]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[SABITHA]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acitretin and Aloe-emodin loaded chitin nanogel for the treatment of psoriasis]]></article-title>
<source><![CDATA[Eur J Pharm Biopharm]]></source>
<year>2016</year>
<volume>107</volume>
<page-range>97-109</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[AGARWAL]]></surname>
<given-names><![CDATA[S. K.]]></given-names>
</name>
<name>
<surname><![CDATA[SINGH]]></surname>
<given-names><![CDATA[S. S.]]></given-names>
</name>
<name>
<surname><![CDATA[VERMA]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[KUMAR]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antifungal activity of anthraquinone derivatives from Rheum emodi]]></article-title>
<source><![CDATA[J Ethnopharm]]></source>
<year>2000</year>
<volume>72</volume>
<page-range>43-6</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[NG]]></surname>
<given-names><![CDATA[Y. C.]]></given-names>
</name>
<name>
<surname><![CDATA[KIM]]></surname>
<given-names><![CDATA[Y. W.]]></given-names>
</name>
<name>
<surname><![CDATA[RYU]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[LEE]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[LEE]]></surname>
<given-names><![CDATA[J.-S.]]></given-names>
</name>
<name>
<surname><![CDATA[SONG]]></surname>
<given-names><![CDATA[M. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Suppression of norovirus by natural phytochemicals from Aloe vera and Eriobotryae Folium]]></article-title>
<source><![CDATA[Food Control]]></source>
<year>2017</year>
<volume>73</volume>
<page-range>1362-70</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[LI]]></surname>
<given-names><![CDATA[S.-W.]]></given-names>
</name>
<name>
<surname><![CDATA[YANG]]></surname>
<given-names><![CDATA[T.-C.]]></given-names>
</name>
<name>
<surname><![CDATA[LAI]]></surname>
<given-names><![CDATA[C.-C.]]></given-names>
</name>
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[S.-H.]]></given-names>
</name>
<name>
<surname><![CDATA[LIAO]]></surname>
<given-names><![CDATA[J.-M.]]></given-names>
</name>
<name>
<surname><![CDATA[WAN]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[LIN]]></surname>
<given-names><![CDATA[Y.-J.]]></given-names>
</name>
<name>
<surname><![CDATA[LIN]]></surname>
<given-names><![CDATA[C.-W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation]]></article-title>
<source><![CDATA[Eur J Pharmac]]></source>
<year>2014</year>
<volume>738</volume>
<page-range>125-32</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BARNARD]]></surname>
<given-names><![CDATA[D. L.]]></given-names>
</name>
<name>
<surname><![CDATA[HUFFMAN]]></surname>
<given-names><![CDATA[J. H.]]></given-names>
</name>
<name>
<surname><![CDATA[MORRIS]]></surname>
<given-names><![CDATA[J. L. B.]]></given-names>
</name>
<name>
<surname><![CDATA[WOOD]]></surname>
<given-names><![CDATA[S. G.]]></given-names>
</name>
<name>
<surname><![CDATA[HUGHES]]></surname>
<given-names><![CDATA[B. G.]]></given-names>
</name>
<name>
<surname><![CDATA[SIDWELL]]></surname>
<given-names><![CDATA[R. W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus]]></article-title>
<source><![CDATA[Antiviral Res]]></source>
<year>1992</year>
<volume>17</volume>
<page-range>63-77</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DAI]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[HARINANTENAINA]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[BOWMAN]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
<name>
<surname><![CDATA[FONSECA]]></surname>
<given-names><![CDATA[I. O. D.]]></given-names>
</name>
<name>
<surname><![CDATA[BRODIE]]></surname>
<given-names><![CDATA[P. J.]]></given-names>
</name>
<name>
<surname><![CDATA[GOETZ]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[CASSERA]]></surname>
<given-names><![CDATA[M. B.]]></given-names>
</name>
<name>
<surname><![CDATA[KINGSTON]]></surname>
<given-names><![CDATA[D. G. I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds]]></article-title>
<source><![CDATA[Bioorg Med Chem]]></source>
<year>2014</year>
<volume>22</volume>
<page-range>269-76</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[PILLAY]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Synthesis and Biological Activity of Aloin Derivatives]]></source>
<year>2008</year>
<publisher-loc><![CDATA[Pietermaritzburg, South Africa ]]></publisher-loc>
<publisher-name><![CDATA[University of KwaZulu-Natal]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CUI]]></surname>
<given-names><![CDATA[X.-R.]]></given-names>
</name>
<name>
<surname><![CDATA[TAKAHASHI]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[SHIMAMURA]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[KOYANAGI]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[KOMADA]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[SAITO]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preparation of 1,8-Di-O-alkylaloe-emodins and 15-Amino-, 15-Thiocyano-, and 15-Selenocyanochrysophanol Derivatives from Aloe-Emodin and Studying Their Cytotoxic Effects]]></article-title>
<source><![CDATA[Chem Pharm Bull]]></source>
<year>2008</year>
<volume>56</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>497-503</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[KOYAMA]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[TAKAHASHI]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[CHOU]]></surname>
<given-names><![CDATA[T.-C.]]></given-names>
</name>
<name>
<surname><![CDATA[DARZYNKIEWICZ]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[KAPUSCINSKI]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[KELLY]]></surname>
<given-names><![CDATA[T. R.]]></given-names>
</name>
<name>
<surname><![CDATA[WATANABE]]></surname>
<given-names><![CDATA[K. A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intercalating Agents with Covalent Bond Forming Capability. A Novel Type of Potential Anticancer Agents. 2.1 Derivatives of Chrysophanol and Emodin]]></article-title>
<source><![CDATA[J Med Chem]]></source>
<year>1989</year>
<volume>32</volume>
<page-range>1594-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[HANESSIAN]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[GUESNE]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[RIBER]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[MARIN]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[BENOIST]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[MENNECIER]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[RUPIN]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[VERBEUREN]]></surname>
<given-names><![CDATA[T. J.]]></given-names>
</name>
<name>
<surname><![CDATA[DE NANTEUIL]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Targeting ACE and ECE with dual acting inhibitors]]></article-title>
<source><![CDATA[Bioorg Med Chem Lett]]></source>
<year>2008</year>
<volume>18</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1058-62</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SHI]]></surname>
<given-names><![CDATA[D.-H.]]></given-names>
</name>
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[LI]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[WANG]]></surname>
<given-names><![CDATA[L.-T.]]></given-names>
</name>
<name>
<surname><![CDATA[WANG]]></surname>
<given-names><![CDATA[S.-F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors]]></article-title>
<source><![CDATA[Bioorg Med Chem]]></source>
<year>2013</year>
<volume>21</volume>
<page-range>1064-73</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ABDEL-MAGID]]></surname>
<given-names><![CDATA[A. F.]]></given-names>
</name>
<name>
<surname><![CDATA[MARYANOFF]]></surname>
<given-names><![CDATA[C. A.]]></given-names>
</name>
<name>
<surname><![CDATA[CARSON]]></surname>
<given-names><![CDATA[K. G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reductive Amination of Aldehydes and Ketones by Using Sodium Triacetoxyborohydride]]></article-title>
<source><![CDATA[Tetrahedron Lett]]></source>
<year>1990</year>
<volume>31</volume>
<numero>39</numero>
<issue>39</issue>
<page-range>5595-8</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ABDEL-MAGID]]></surname>
<given-names><![CDATA[A. F.]]></given-names>
</name>
<name>
<surname><![CDATA[CARSON]]></surname>
<given-names><![CDATA[K. G.]]></given-names>
</name>
<name>
<surname><![CDATA[HARRIS]]></surname>
<given-names><![CDATA[B. D.]]></given-names>
</name>
<name>
<surname><![CDATA[MARYANOFF]]></surname>
<given-names><![CDATA[C. A.]]></given-names>
</name>
<name>
<surname><![CDATA[SHAH]]></surname>
<given-names><![CDATA[R. D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures]]></article-title>
<source><![CDATA[J Org Chem]]></source>
<year>1996</year>
<volume>61</volume>
<page-range>3849-62</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MATTSON]]></surname>
<given-names><![CDATA[R. J.]]></given-names>
</name>
<name>
<surname><![CDATA[PHAM]]></surname>
<given-names><![CDATA[K. M.]]></given-names>
</name>
<name>
<surname><![CDATA[LEUCK]]></surname>
<given-names><![CDATA[D. J.]]></given-names>
</name>
<name>
<surname><![CDATA[COWEN]]></surname>
<given-names><![CDATA[K. A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An improved method for reductive alkylation of amines using titanium(IV) isopropoxide and sodium cyanoborohydride]]></article-title>
<source><![CDATA[J Org Chem]]></source>
<year>1990</year>
<volume>55</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2552-4</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BANDGAR]]></surname>
<given-names><![CDATA[B. P.]]></given-names>
</name>
<name>
<surname><![CDATA[NIKAT]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[WADGAONKAR]]></surname>
<given-names><![CDATA[P. P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Reduction of Aromatic Oximes to Amines with Borohydride Exchange Resin-Nickel Acetate System]]></article-title>
<source><![CDATA[Synth Comm]]></source>
<year>1995</year>
<volume>25</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>863-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BRUSSEE]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[BENTHEM]]></surname>
<given-names><![CDATA[R. A. T. M. V.]]></given-names>
</name>
<name>
<surname><![CDATA[KRUSE]]></surname>
<given-names><![CDATA[C. G.]]></given-names>
</name>
<name>
<surname><![CDATA[GEN]]></surname>
<given-names><![CDATA[A. V. D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Magnesium ion mediated stereospecific formation of N-substituted ethanolamines during reductive amination]]></article-title>
<source><![CDATA[Tetrahedron: Asymmetry]]></source>
<year>1990</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>163-6</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SHI]]></surname>
<given-names><![CDATA[D.-H.]]></given-names>
</name>
<name>
<surname><![CDATA[HUANG]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[LI]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[LIU]]></surname>
<given-names><![CDATA[Y.-W.]]></given-names>
</name>
<name>
<surname><![CDATA[WANG]]></surname>
<given-names><![CDATA[S.-F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors]]></article-title>
<source><![CDATA[Eur J Med Chem]]></source>
<year>2014</year>
<volume>75</volume>
<page-range>289-96</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[LIU]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[WU]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[CHEN]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design and synthesis of aloe-emodin derivatives as potent anti-tyrosinase, antibacterial and anti-inflammatory agents]]></article-title>
<source><![CDATA[Bioorg Med Chem Lett]]></source>
<year>2015</year>
<volume>25</volume>
<page-range>5142-6</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ROY]]></surname>
<given-names><![CDATA[B. N.]]></given-names>
</name>
<name>
<surname><![CDATA[SING]]></surname>
<given-names><![CDATA[G. P.]]></given-names>
</name>
<name>
<surname><![CDATA[LATHI]]></surname>
<given-names><![CDATA[P. S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eco-friendly method for catalytic aerial oxidation of Aloe-emodin to rheinal: An intermediate for diacerein]]></article-title>
<source><![CDATA[Indian J Chem]]></source>
<year>2012</year>
<volume>51B</volume>
<page-range>988-91</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ZHANG]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[ZHANG]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[WU]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Preparation of rhein from aloe-emodin in nonmetallicoxidate medium]]></source>
<year>2009</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>13-6</page-range><publisher-name><![CDATA[Dalian Gongye Daxue Xuebao]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[YANG-MING]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[DIANGEN]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[WENJIE]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[BO]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Technique for preparing diacerein by two-step oxidation process]]></source>
<year>2006</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
