<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-6185</journal-id>
<journal-title><![CDATA[Tecnología Química]]></journal-title>
<abbrev-journal-title><![CDATA[RTQ]]></abbrev-journal-title>
<issn>2224-6185</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-61852019000300638</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Simulación de propuestas tecnológicas para la producción de ramnolípidos ORA9 a escala piloto]]></article-title>
<article-title xml:lang="en"><![CDATA[Simulation of technological proposals for rhamnolipids ORA9 production at pilot scale]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Gámez]]></surname>
<given-names><![CDATA[MSc. Odalys]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nápoles-Alvarez]]></surname>
<given-names><![CDATA[MSc. Janet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[DraC. Yudith González]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ábalos-Rodríguez]]></surname>
<given-names><![CDATA[DraC.Arelis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,aff2  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>39</volume>
<numero>3</numero>
<fpage>638</fpage>
<lpage>654</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-61852019000300638&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-61852019000300638&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-61852019000300638&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los ramnolipidos son biosurfactantes glicolipídicos producidos por bacterias del género Pseudomona y representan una alternativa ecológica a sus contrapartes de origen petroquímico pues exhiben baja toxicidad, alta actividad superficial y son estables en condiciones extremas de pH, temperatura y salinidad. En este trabajo se realizó la simulación de dos propuestas tecnológicas para el proceso de producción de ramnolipidos ORA9 a escala piloto. Con el empleo del software SuperPro Designer® se determinó que se necesitan 126 ciclos productivos con una duración de 144 horas cada uno para producir 67 kg de ramnolipidos y 11 kg de PHA. El punto crítico o cuello de botella lo constituye la etapa de fermentación con aproximadamente 50 horas de duración. En ambas variantes fue posible aumentar la productividad de la planta hasta 95 kg de ramnolipidos y 16 kg de polihidroxialcanoatos al año con el empleo de cuatro fermentadores operando en modo escalonado. Los residuales generados en ambas propuestas no constituyen riesgo para el medio ambiente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The rhamnolipids are glycolipid biosurfactants produced by bacteria of the genus Pseudomona and represent an ecological alternative to their counterparts of petrochemical origin because they exhibit low toxicity, high surface activity and are stable under extreme conditions of pH, temperature and salinity.In this work the simulation of two technological proposals for rhamnolipids ORA9 production process at pilot scale was carried out. With the use of SuperPro Designer® software, it was determined that 126 production cycles with a duration of 144 hours each are required to produce 67 kg of rhamnolipids and 11 kg of polyhydroxyalkanoates. The critical point or bottleneck is the fermentation stage with approximately 50 hours of duration. In both variants was possible to increase the plant productivity up to 95 kg of rhamnolipidsand 16 kg of polyhydroxyalkanoatesper year with the use of four fermenters operating in staggered mode. The residuals generated in both proposals do not constitute a risk for the environment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[simulación]]></kwd>
<kwd lng="es"><![CDATA[ramnolipidos]]></kwd>
<kwd lng="es"><![CDATA[polihidroxialcanoatos]]></kwd>
<kwd lng="es"><![CDATA[programa SuperPro Designer]]></kwd>
<kwd lng="en"><![CDATA[simulation]]></kwd>
<kwd lng="en"><![CDATA[rhamnolipids]]></kwd>
<kwd lng="en"><![CDATA[polyhydroxyalkanoates]]></kwd>
<kwd lng="en"><![CDATA[SuperPro Designer software]]></kwd>
</kwd-group>
</article-meta>
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