<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272021000100020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características clínico-epidemiológicas en pacientes hospitalizados con úlcera grave de la córnea]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinico-epidemiological characteristics in hospitalized patients with severe corneal ulcer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Vázquez]]></surname>
<given-names><![CDATA[Niurka]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña Mollineda]]></surname>
<given-names><![CDATA[Daylenis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Milán]]></surname>
<given-names><![CDATA[Yudalkys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardet Sánchez]]></surname>
<given-names><![CDATA[Carol]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>15</volume>
<numero>1</numero>
<fpage>20</fpage>
<lpage>28</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272021000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272021000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272021000100020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la úlcera corneal grave es una enfermedad que no tratada oportunamente suele cursar con complicaciones y secuelas y llegar a comprometer la función visual, por lo que requiere de estricto seguimiento y de ingreso hospitalario.  Objetivo:  describir el comportamiento clínico-epidemiológico de pacientes con diagnóstico de úlcera grave de la córnea.  Métodos:  estudio descriptivo, transversal en 52 pacientes hospitalizados con diagnóstico de úlcera grave de la córnea en el Hospital &#8220;Arnaldo Milián Castro&#8221; de la Provincia de Villa Clara en el período comprendido desde enero de 2016 hasta diciembre de 2019.  Resultados:  predominaron los hombres (67,3%) con edades de 60 años y más, este mismo grupo etario fue el de mayor número de pacientes (63,4%), el 75% tenían procedencia rural y aquí el sexo masculino aportó un 50%, las enfermedades sistémicas se manifestaron como principal factor predisponente en un 69,2%, en el 71,2% de las muestras para cultivo se aislaron bacterias, por lo que la vancomicina y la ceftazidima en colirios fortificados se utilizaron, cada una, en 40 de los pacientes del estudio, el 34,6% presentaron complicaciones y fue la perforación corneal (19,2%) la predominante, el 67,3% mantuvieron una estadía hospitalaria de ocho a 14 días.  Conclusiones:  las queratitis infecciosas graves son frecuentes en adultos mayores del sexo masculino con procedencia rural, las enfermedades sistémicas constituyen el principal factor predisponente, son las bacterias el agente causal en su mayoría, se utilizaron fundamentalmente los colirios fortificados de vancomicina y ceftazidima y las complicaciones, como la perforación corneal, conllevan a un aumento en la estadía hospitalaria.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  severe corneal ulcer is a disease that is not treated in a timely manner, usually with complications and sequelae and can compromise visual function, requiring strict monitoring and hospitalization.  Objective:  to describe the clinical-epidemiological behavior of patients diagnosed with severe corneal ulcer.  Methods:  descriptive, cross-sectional study in 52 hospitalized patients diagnosed with severe corneal ulcer at &#8220;Arnaldo Milián Castro&#8221; Hospital in Villa Clara Province in the period from January 2016 to December 2019.  Results:  Men predominated (67.3%) with ages of 60 years and older, this same age group had the highest number of patients (63.4%), 75% were of rural origin and here the male sex contributed 50%, systemic diseases were the main predisposing factor in 69.2%, in 71, Bacteria were isolated from 2% of the culture samples, so vancomycin and ceftazidime in fortified eye drops were used, each one, in 40 of the patients in the study, 34.6% presented complications and it was corneal perforation (19.2%) the predominant one, 67.3% maintained a hospital stay of 8 to 14 days.  Conclusions:  severe infectious keratitis is frequent in older male adults of rural origin, systemic diseases are the main predisposing factor, bacteria are the causal agent in the majority, vancomycin and ceftazidime fortified eye drops were mainly used and complications, such as corneal perforation, lead to an increase in hospital stay.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[úlcera grave de la córnea]]></kwd>
<kwd lng="es"><![CDATA[perforación corneal]]></kwd>
<kwd lng="es"><![CDATA[descematocele]]></kwd>
<kwd lng="en"><![CDATA[severe corneal ulcer]]></kwd>
<kwd lng="en"><![CDATA[corneal perforation]]></kwd>
<kwd lng="en"><![CDATA[descematocele]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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