<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272022000200272</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diagnóstico etiológico y epidemiología de la cromoblastomicosis]]></article-title>
<article-title xml:lang="en"><![CDATA[Etiologic diagnosis and epidemiology of chromoblastomycosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Gómez]]></surname>
<given-names><![CDATA[Dianiley]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Durán Morera]]></surname>
<given-names><![CDATA[Noira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Rodríguez]]></surname>
<given-names><![CDATA[José Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mesa Coello]]></surname>
<given-names><![CDATA[Leisky]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Artiles Martínez]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Ginecoobstétrico Universitario &#8220;Mariana Grajales&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>16</volume>
<numero>2</numero>
<fpage>272</fpage>
<lpage>279</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272022000200272&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272022000200272&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272022000200272&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la cromoblastomicosis es una micosis subcutánea, crónica, causada por un grupo de hongos dematiáceos; Fonsecaea pedrosoi es de los agentes etiológicos más frecuentes, está presente en climas tropicales, de abundante vegetación. El diagnóstico se basa en tres pilares fundamentales: el clínico-epidemiológico, el de Anatomía Patológica y el microbiológico.  Objetivo:  describir el diagnóstico etiológico y las variables epidemiológicas de interés de la enfermedad en la Provincia de Villa Clara durante el período de 2003 a 2018.  Métodos:  estudio descriptivo, transversal en una población de 47 pacientes. Como medida de resumen se utilizaron las frecuencias absolutas y relativas y para la exploración espaciotemporal la técnica de Kulldorff.  Resultados:  del total de pacientes al 19% se le realizaron estudios micológicos en los que se aislaron las especies Fonsecaea pedrosoi, Cladophialophora carrionii y Phialophora verrucosa. En el Municipio de Manicaragua se identificó un conglomerado espacial verdadero de alta tasa de incidencia. Fue 2,12 veces más frecuente en hombres que en mujeres.  Conclusiones:  en la provincia no existe integración clínica, anatomopatológica y microbiológica para el diagnóstico de la cromoblastomicosis; al menos tres agentes etiológicos conocidos, Fonsecaea pedrosoi, Cladophialophora carrionii y Phialophora verrucosa, fueron causa de la enfermedad durante el período estudiado. El Municipio montañoso de Manicaragua constituye un área geográfica de alto riesgo en la provincia. El sexo más afectado por la enfermedad fue el masculino.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Chromoblastomycosis is a chronic subcutaneous mycosis caused by a group of dematiaceous fungi; Fonsecaea pedrosoi is one of the most frequent etiological agents and is found in tropical climates with abundant vegetation. The diagnosis is based on three fundamental pillars: clinical-epidemiological, pathological anatomy and microbiological.  Objective:  to describe the etiological diagnosis and epidemiological variables of interest of the disease in Villa Clara Province during the period from 2003 to 2018.  Methods:  descriptive, cross-sectional study in a population of 47 patients. Absolute and relative frequencies were used as summary measures and the Kulldorff technique was used for spatiotemporal exploration.  Results:  from the total number of patients, 19% were submitted to mycological studies in which the species Fonsecaea pedrosoi, Cladophialophora carrionii and Phialophora verrucosa were isolated. In the municipality of Manicaragua, a true spatial cluster with a high incidence rate was identified. It was 2.12 times more frequent in men than in women.  Conclusions:  in the province there is no clinical, anatomopathological and microbiological integration for the diagnosis of chromoblastomycosis; at least three known etiological agents, Fonsecaea pedrosoi, Cladophialophora carrionii and Phialophora verrucosa, were the cause of the disease during the period studied. The mountainous municipality of Manicaragua constitutes a high-risk geographical area in the province. The sex most affected by the disease was male.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[cromoblastomicosis]]></kwd>
<kwd lng="es"><![CDATA[hongos dematiáceos]]></kwd>
<kwd lng="es"><![CDATA[dermatomicosis]]></kwd>
<kwd lng="en"><![CDATA[chromoblastomycosis]]></kwd>
<kwd lng="en"><![CDATA[dematiaceous fungi]]></kwd>
<kwd lng="en"><![CDATA[dermatomycosis]]></kwd>
</kwd-group>
</article-meta>
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