<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272022000200366</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Linfoma difuso de células B grandes cutáneo primario. Informe de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Diffuse lymphoma of primary cutaneous large B-cell. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Escudero]]></surname>
<given-names><![CDATA[Mabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales Piñeiro]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sosa Estebanez]]></surname>
<given-names><![CDATA[Hanuarys Lázaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial General Universitario &#8220;Mártires del 9 de Abril&#8221;  ]]></institution>
<addr-line><![CDATA[Sagua la Grande Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>16</volume>
<numero>2</numero>
<fpage>366</fpage>
<lpage>373</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272022000200366&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272022000200366&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272022000200366&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el linfoma cutáneo primario de células B es una proliferación neoplásica poco frecuente de linfocitos de inmunofenotipo B; sus mecanismos patogénicos se desconocen.  Información del paciente:  se presenta un paciente masculino de 77 años de edad, que hace aproximadamente tres meses comenzó con placas eritemato-violáceas, infiltradas, multifocales, localizadas en el tronco posterior, además de una tumoración violácea, con vasos de neoformación en su superficie, lo que se acompañó de pérdida de peso. Fue valorado multidisciplinariamente y tras biopsia de la lesión y estudios de estadiaje se concluyó como linfoma difuso de células B grandes cutáneo primario. Se indicó como tratamiento poliquimioterapia con ciclofosfamida, doxorubicina, vincristina y prednisona y anticuerpo monoclonal: rituximab, con evolución favorable.  Conclusiones:  esta enfermedad, aun siendo poco frecuente, de buen pronóstico y de relativamente fácil manejo terapéutico, debe ser sospechada y diagnosticada a tiempo; no se deben olvidar las connotaciones que su diagnóstico y su tratamiento implican para el paciente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  primary cutaneous B-cell lymphoma is a rare neoplastic proliferation of immunophenotype B lymphocytes; its pathogenic mechanisms are unknown.  Patient information:  a 77-year-old male patient is presented, who approximately three months ago started with erythematous-violaceous, infiltrated, multifocal plaques, located on the posterior trunk, in addition to a violaceous tumor, with neoformation vessels on its surface, which was accompanied by weight loss. He was evaluated multidisciplinary and after biopsy of the lesion and staging studies it was concluded asDiffuse lymphoma of primary cutaneous large B-cell. Polychemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone and monoclonal antibody: rituximab was indicated as treatment, with favorable evolution.  Conclusions:  this disease, even being unfrequent, with a good prognosis and relatively easy therapeutic management, should be suspected and diagnosed in time; the connotations that its diagnosis and treatment imply for the patient should not be forgotten.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[linfoma de células B]]></kwd>
<kwd lng="es"><![CDATA[linfoma difuso de células B grandes]]></kwd>
<kwd lng="es"><![CDATA[rituximab]]></kwd>
<kwd lng="en"><![CDATA[B-cell lymphoma]]></kwd>
<kwd lng="en"><![CDATA[diffuse large B-cell lymphoma]]></kwd>
<kwd lng="en"><![CDATA[rituximab]]></kwd>
</kwd-group>
</article-meta>
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