<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7493</journal-id>
<journal-title><![CDATA[Revista Cubana de Cirugía]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Cir]]></abbrev-journal-title>
<issn>0034-7493</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74932018000400008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Uso de ácido tranexámico en las hemorragias]]></article-title>
<article-title xml:lang="en"><![CDATA[Use of traxenamic acid in hemorrhages]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piamo Morales]]></surname>
<given-names><![CDATA[Alberto J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[Mayra A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico Docente &#8220;Joaquín Albarrán&#8221;  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Ginecobstétrico &#8220;América Arias&#8221;  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>57</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-74932018000400008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-74932018000400008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-74932018000400008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Según las evidencias científicas actuales, la administración de un tratamiento simple y económico con propiedades antifibrinolíticas, como el ácido tranexámico pudiera reducir la pérdida sanguínea luego de un trauma y disminuir el riesgo asociado a transfusiones sanguíneas. El ácido tranexámico es un derivado sintético de la lisina con una actividad antifibrinolítica pura. Su mecanismo de acción se basa en la unión al enlace de la lisina del plasminógeno, lo que bloquea la unión de la fibrina al complejo activador del plasminógeno-plasmina.Ante tal evidencia, esta revisión se propone describir los resultados del empleo del ácido tranexámico según la evidencia disponible. Para ello se realizó una búsqueda en bases de datos como PubMed, SciELO y ClinicalKeys.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT According to the present scientific evidence, the administration of a simple economic treatment with anti-fibrinolytic properties such as the tranexamic acid can reduce the blood loss after trauma, and decrease the risk associated to blood transfusions. Tranexamic acid is a synthetic derivative of lysine with pure anti-fibrinolytic activity. Its mechanism of action is based on the joining to the plasminogen lysine bond, which blocks the binding of fibrin to the activating complex of plasminogen-plasmin. This review was aimed at describing the results of the use of tranexamic acid based on available evidence. To this end, a literature search was made in PubMed, SciELO and Clinical Keys databases.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácido tranexámico]]></kwd>
<kwd lng="es"><![CDATA[trauma]]></kwd>
<kwd lng="es"><![CDATA[hemorragia aguda]]></kwd>
<kwd lng="es"><![CDATA[anti-fibrinólisis]]></kwd>
<kwd lng="en"><![CDATA[tranexamic acid]]></kwd>
<kwd lng="en"><![CDATA[trauma]]></kwd>
<kwd lng="en"><![CDATA[acute hemorrhage]]></kwd>
<kwd lng="en"><![CDATA[anti-fibrinolysis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<collab>CRASH-2 Collaborators</collab>
<article-title xml:lang=""><![CDATA[Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) a randomised, placebocontrolled trial]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2010</year>
<volume>376</volume>
<numero>9734</numero>
<issue>9734</issue>
<page-range>23-32</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="">
<source><![CDATA[Anuario Estadístico Ministerio de Salud Pública]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Cuba ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kauvar]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Wade]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The epidemiology and modern management of traumatic hemorrhage US and International perspectives]]></article-title>
<source><![CDATA[Critical Care]]></source>
<year>2005</year>
<volume>9</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wee]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Clyburn]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Walker]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Brohi]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Collins]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of Anaesthetists of Great Britain and Ireland, ºBlood transfusion and the anaesthetist management of massive haemorrhage]]></article-title>
<source><![CDATA[Anaesthesia]]></source>
<year>2010</year>
<volume>65</volume>
<page-range>1153-61</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Johansson]]></surname>
<given-names><![CDATA[PI]]></given-names>
</name>
<name>
<surname><![CDATA[Ostrowski]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Secher]]></surname>
<given-names><![CDATA[NH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of major blood loss An update]]></article-title>
<source><![CDATA[Acta Anaesthesiol Scand]]></source>
<year>2010</year>
<volume>54</volume>
<page-range>1039-49</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gillette]]></surname>
<given-names><![CDATA[BP]]></given-names>
</name>
<name>
<surname><![CDATA[DeSimone]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Trousdale]]></surname>
<given-names><![CDATA[RT]]></given-names>
</name>
<name>
<surname><![CDATA[Pagnano]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Sierra]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Low risk of thromboembolic complications with tranexamicacidafter primary total hip and knee arthroplasty]]></article-title>
<source><![CDATA[Clin Orthop Relat Res]]></source>
<year>2013</year>
<volume>471</volume>
<page-range>150-4</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pinzón-Florez]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
<name>
<surname><![CDATA[Vélez]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efectividad del ácido tranexámico en las pérdidas sanguíneas perioperatorias en la artroplastia de cadera revisión sistemática de la literatura y metaanálisis]]></article-title>
<source><![CDATA[Rev Esp Anestesiol Reanim]]></source>
<year>2015</year>
<volume>62</volume>
<page-range>253-64</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Charles]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Górriz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Coderch]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ácido tranexámicointravenoso en la artroplastia total primaria de rodilla]]></article-title>
<source><![CDATA[MedClin(Barc)]]></source>
<year>2014</year>
<volume>143</volume>
<page-range>421-2</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguilera-Roig]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Jordán-Sales]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Natera-Cisneros]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Monllau-García]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Zapata]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ácido tranexámico en cirugíaortopédica]]></article-title>
<source><![CDATA[Rev Esp Cir OrtopTraumatol]]></source>
<year>2014</year>
<volume>58</volume>
<page-range>52-6</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Canillas F]]></surname>
<given-names><![CDATA[Gómez-Ramírez S]]></given-names>
</name>
<name>
<surname><![CDATA[García-Erce JA]]></surname>
<given-names><![CDATA[Pavía-MolinaJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez-Luque A]]></surname>
<given-names><![CDATA[Muñoz M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Patient blood management en cirugía ortopédica]]></article-title>
<source><![CDATA[Rev Esp Cir OrtopTraumatol]]></source>
<year>2015</year>
<volume>59</volume>
<page-range>137-49</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morrison]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Dubose]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rasmussen]]></surname>
<given-names><![CDATA[TE]]></given-names>
</name>
<name>
<surname><![CDATA[Midwinter]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[MilitaryApplication of Tranexamic Acid in Trauma Emergency Resusci-tation (MATTERs) Study]]></article-title>
<source><![CDATA[Arch Surg]]></source>
<year>2012</year>
<volume>147</volume>
<page-range>113-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morrison]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Ross]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Dubose]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Jansen]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Midwinter]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Ras-mussen]]></surname>
<given-names><![CDATA[TE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of cryoprecipitate and tranexamicacidwith improved survival following wartime injury Findings fromthe MATTERs II study]]></article-title>
<source><![CDATA[JAMA Surg]]></source>
<year>2013</year>
<volume>148</volume>
<page-range>218-25</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="">
<source><![CDATA[Joint Theater Trauma System Clinical Practice Guidelines. Damage control resuscitation at level IIb/III treatment facili-ties]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pusateri]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<name>
<surname><![CDATA[Weiskopf]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
<name>
<surname><![CDATA[Bebarta]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Butler]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Cestero]]></surname>
<given-names><![CDATA[RF]]></given-names>
</name>
<name>
<surname><![CDATA[Chaun-dry]]></surname>
<given-names><![CDATA[IH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tranexamic acid in trauma Current status andknowledge gaps with recommended research priorities]]></article-title>
<source><![CDATA[Shock]]></source>
<year>2013</year>
<volume>39</volume>
<page-range>121-6</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blackbourne]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
<name>
<surname><![CDATA[Baer]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Eastridge]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Renz]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Ching]]></surname>
<given-names><![CDATA[KK]]></given-names>
</name>
<name>
<surname><![CDATA[Dubose]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Military medical revolution Deployed hospitaland en route care]]></article-title>
<source><![CDATA[J Trauma Acute Care Surg]]></source>
<year>2012</year>
<volume>73</volume>
<page-range>378-87</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dunn]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Goa]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tranexamic acid A review of its use in surgery and other indications]]></article-title>
<source><![CDATA[Drugs]]></source>
<year>1999</year>
<volume>57</volume>
<page-range>1005-32</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mc Cormack]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Review of its Use in the Treatment of Hyperfibrinolysis: 2010]]></article-title>
<source><![CDATA[Drugs]]></source>
<year>2012</year>
<volume>72</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>585-617</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[O'Brien]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effectsoftranexamic acid and aprotinin, two antifibrinolyticdrugs, on PAF-induced plasma extravasation in unanesthetizedrats]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Battistini]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Zaharia]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Plante]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
<name>
<surname><![CDATA[Sirois]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Inflammation]]></source>
<year>2000</year>
<volume>24</volume>
<page-range>411-29</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[TK]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
<name>
<surname><![CDATA[Koh]]></surname>
<given-names><![CDATA[IJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Practical issues for the use of tra-nexamic acid in total knee arthroplasty a systematic review.KneeSurg Sports]]></article-title>
<source><![CDATA[TraumatolArthrosc]]></source>
<year>2014</year>
<volume>22</volume>
<page-range>1849-58</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poeran]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the UnitedStates retrospective analysis of effectiveness and safety]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Rasul]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Suzuki]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Danninger]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Mazumdar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Opperer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[BMJ]]></source>
<year>2014</year>
<volume>349</volume>
<page-range>4829</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gandhi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Evans]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
<name>
<surname><![CDATA[Mahomed]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Mahomed]]></surname>
<given-names><![CDATA[NN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tranexamicacid and the reduction of blood loss in total knee and hip arth-roplasty a meta-analysis]]></article-title>
<source><![CDATA[BMC Res Notes]]></source>
<year>2013</year>
<volume>6</volume>
<page-range>184</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sukeik]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Alshryda]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Haddad]]></surname>
<given-names><![CDATA[FS]]></given-names>
</name>
<name>
<surname><![CDATA[Mason]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systematic review and metaanalysis of the use of tranexamic acid in total hip replacement]]></article-title>
<source><![CDATA[J Bone Joint Surg Br]]></source>
<year>2011</year>
<volume>93</volume>
<page-range>39-46</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alshryda]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sarda]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Sukeik]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nargol]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Blenkinsopp]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mason]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tranexamic acid in total knee replacement A systematic review and metaanalysis]]></article-title>
<source><![CDATA[J Bone Joint Surg Br]]></source>
<year>2011</year>
<volume>93</volume>
<page-range>1577-85</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[ZG]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[WP]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty A meta-analysis]]></article-title>
<source><![CDATA[J Bone Joint Surg Am]]></source>
<year>2012</year>
<volume>94</volume>
<page-range>1153-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muñoz Gómez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Páramo Fernández]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Administración intravenosa de ácido tranexámico para reducir la hemorragia y la transfusión en cirugía protésica de rodilla y cadera ¿es segura y coste-efectiva?Med]]></article-title>
<source><![CDATA[Clin (Barc)]]></source>
<year>2013</year>
<volume>141</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>207-9</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kagoma]]></surname>
<given-names><![CDATA[YK]]></given-names>
</name>
<name>
<surname><![CDATA[Crowther]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Douketis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bhandari]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Eikelboom]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery A systematic review of randomized trials]]></article-title>
<source><![CDATA[Thromb Res]]></source>
<year>2009</year>
<volume>123</volume>
<page-range>687-96</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanz-Reig]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Parra Ruiz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrández Martínez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez López]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dosis única intravenosa de ácido tranexámico como medida de ahorro transfusional en prótesis total primaria de rodilla]]></article-title>
<source><![CDATA[Rev Esp Cir Ortop Traumatol]]></source>
<year>2016</year>
<volume>60</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>106-12</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aedo-Martín]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[García-Cañas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Navarro-Suay]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Roldán]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Baños-Turz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Tamburri-Bariain]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Empleo de ácido tranexámico en el herido de combate, experiencia de la sanidad militar española Serie de casos y revisión de la literatura]]></article-title>
<source><![CDATA[Rev Esp Cir Ortop Traumatol]]></source>
<year>2016</year>
<volume>60</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>200-5</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castro-Menéndez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eficacia de 2 gramos intravenosos de ácido tranexámico en la reducción del sangrado postoperatorio de la artroplastia total de cadera y rodilla]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Pena-Paz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rocha-García]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez-Casas]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Huici-Izco]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Montero-Viéites]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Esp Cir Ortop Traumatol]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zapata Avendaño]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Muñoz Acosta]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández Arias]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Administración de ácido tranexámico para hemorragia descompensada en la atención primaria del trauma]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Medellín ]]></publisher-loc>
<publisher-name><![CDATA[Universidad CES]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Larrea Fabra]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[González Sosa]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Falcón Córdova]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
</person-group>
<source><![CDATA[Uso del ácido tranexámico en el sangrado digestivo alto. Informe preliminar]]></source>
<year>2011</year>
<publisher-name><![CDATA[Archivos del Hospital Universitario "Gral. Calixto García"]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
