<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7493</journal-id>
<journal-title><![CDATA[Revista Cubana de Cirugía]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Cir]]></abbrev-journal-title>
<issn>0034-7493</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74932020000300011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Heyde]]></article-title>
<article-title xml:lang="en"><![CDATA[Heyde Syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Céspedes Rodríguez]]></surname>
<given-names><![CDATA[Héctor Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Céspedes Rodríguez]]></surname>
<given-names><![CDATA[Héctor Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Pérez]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Hospital Universitario &#8220;Manuel Ascunce Domenech&#8221; ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>59</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-74932020000300011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-74932020000300011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-74932020000300011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El síndrome de Heyde es la asociación entre estenosis valvular aórtica y sangrado gastrointestinal, por angiodisplasia intestinal. La base fisiopatológica de ese síndrome parece ser una deficiencia adquirida del factor de Von Willebrand, que lleva al sangrado de malformaciones arteriovenosas angiodisplásicas. Las alternativas de tratamiento incluyen la localización de puntos de sangrado y la cauterización, pero tal opción terapéutica está asociada a alta recurrencia. El reemplazo de la válvula parece ofrecer la mejor esperanza de resolución a largo plazo del sangrado y debe ser considerada en la mayoría de las veces.  Objetivos: Presentar el caso de un síndrome de Heyde, una causa infrecuente de hemorragia digestiva.  Caso clínico:  Paciente de 74 años con antecedentes estenosis aórtica y sangrado gastrointestinal debido a angiodisplasia duodenal localizada en la segunda porción de esta, tratada mediante la escleroterapia.  Conclusiones:  El síndrome de Heyde es una asociación poco frecuente entre una valvulopatía aortica y sangrado digestivo por una angiodisplasia que puede presentarse en cualquier parte del tubo digestivo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Heyde syndrome is the association between aortic valve stenosis and gastrointestinal bleeding, due to intestinal angiodysplasia. The pathophysiological basis of this syndrome seems to be acquired Von Willebrand factor deficiency, which leads to bleeding from angiodysplastic arteriovenous malformations. Management alternatives include localization of bleeding points and cauterization, but such a therapeutic option is associated with high recurrence. Valve replacement seems to offer the best hope for long-term solving of bleeding and should be considered for most of the cases.  Objectives: To present a case of Heyde syndrome, a rare cause of gastrointestinal bleeding.  Clinical case:  A 74-year-old patient is presented with a history of aortic stenosis and gastrointestinal bleeding due to duodenal angiodysplasia located in the second portion of it, managed by sclerotherapy.  Conclusions:  Heyde syndrome is a rare association between aortic valve disease and digestive bleeding due to angiodysplasia that can occur in any part of the digestive tract.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome de Heyde]]></kwd>
<kwd lng="es"><![CDATA[angiodisplasia intestinal]]></kwd>
<kwd lng="es"><![CDATA[sangrado]]></kwd>
<kwd lng="en"><![CDATA[Heyde syndrome]]></kwd>
<kwd lng="en"><![CDATA[intestinal angiodysplasia]]></kwd>
<kwd lng="en"><![CDATA[bleeding]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heyde]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gastrointestinal bleeding in aortic stenosis]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>1958</year>
<volume>259</volume>
<page-range>196</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Warkentin]]></surname>
<given-names><![CDATA[TE]]></given-names>
</name>
<name>
<surname><![CDATA[Moore]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Morgan]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aortic stenosis and bleeding gastrointestinal angiodysplasia is acquired von Willebrand´s disease the link?]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>1992</year>
<volume>340</volume>
<numero>8810</numero>
<issue>8810</issue>
<page-range>35-7</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morishima]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Marui]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shimamoto]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Saji]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tambara]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Nishina]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Successful aortic valve replacement for Heyde syndro- me with confirmed hematologic recovery]]></article-title>
<source><![CDATA[Ann Thorac Surg]]></source>
<year>2007</year>
<volume>83</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>287-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pate]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
<name>
<surname><![CDATA[Chandavimol]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Naiman]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Webb]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heydes syn- drome a review]]></article-title>
<source><![CDATA[J Heart Valve Dis]]></source>
<year>2004</year>
<volume>13</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>701-12</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vaz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Correia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Capelo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Henriques]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heyde syndrome The link between aortic stenosis and gastrointestinal bleeding]]></article-title>
<source><![CDATA[Rev Port Cardiol]]></source>
<year>2010</year>
<volume>29</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>309-14</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Veyradier]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Balian]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wolf]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Giraud]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Montembault]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Obert]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract]]></article-title>
<source><![CDATA[Gastroenterology]]></source>
<year>2001</year>
<volume>120</volume>
<page-range>346-53</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vincentelli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Susen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Le Tourneau]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Six]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Fabre]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Juthier]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acquired von Willebrand syndrome in aortic stenosis]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2003</year>
<volume>349</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>343-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thompson]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Schaff]]></surname>
<given-names><![CDATA[HV]]></given-names>
</name>
<name>
<surname><![CDATA[Dearani]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sundt]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Suri]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome]]></article-title>
<source><![CDATA[J Thorac Cardiovasc Surg]]></source>
<year>2012</year>
<volume>144</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>112-6</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Godino]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lauretta]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pavon]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Mangieri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Viani]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chieffo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heyde's syndrome incidence and outcome in patients undergoing transcatheter aortic valve implantation]]></article-title>
<source><![CDATA[J Am Coll Cardiol]]></source>
<year>2013</year>
<volume>61</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>687-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Figuinha]]></surname>
<given-names><![CDATA[FCR]]></given-names>
</name>
<name>
<surname><![CDATA[Spina]]></surname>
<given-names><![CDATA[GS]]></given-names>
</name>
<name>
<surname><![CDATA[Tarasoutchi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heyde´s syndrome case report and literature review]]></article-title>
<source><![CDATA[Arq Bras Cardiol]]></source>
<year>2011</year>
<volume>96</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>e42-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
