<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7507</journal-id>
<journal-title><![CDATA[Revista Cubana de Estomatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Estomatol]]></abbrev-journal-title>
<issn>0034-7507</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75072019000100011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La plausibilidad biológica entre la periodontitis crónica y el infarto cerebral isquémico]]></article-title>
<article-title xml:lang="en"><![CDATA[Biological plausibility of the relationship between chronic periodontitis and ischemic stroke]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Díaz]]></surname>
<given-names><![CDATA[María Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad de Estomatología&#8220;Raúl González Sánchez&#8221; ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>56</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75072019000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75072019000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75072019000100011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Las bolsas periodontales reales constituyen un reservorio importante de bacterias gramnegativas que pueden por diversas vías ejercer influencia en sitios distantes, lo cual provoca alteraciones sistémicas como las enfermedades derivadas de la aterosclerosis.  Objetivo:  Explicar los fundamentos teóricos que sustentan la propuesta de la periodontitis crónica como un factor de riesgo para el infarto cerebral isquémico.  Contenido:  1) La aterosclerosis y las enfermedades cerebrovasculares, generalidades de su patogenia. 2) La microbiota periodontal, fundamentos de su asociación con la aterosclerosis y la enfermedad cerebrovascular isquémica.  Exposición del tema:  La inflamación es un elemento de vital importancia en todas las fases del proceso aterosclerótico, tanto en su inicio, progresión, como en sus complicaciones. La naturaleza de las enfermedades periodontales inmunoinflamatorias crónicas y la infección subgingival anaerobia asociada a ellas, representa una injuria metastásica que produce y disemina mediadores inflamatorios favorecedores de la ateroesclerosis, participando en la colonización, y ruptura de placas ateromatosas; procesos implicados en la patogenia del infarto cerebral isquémico.  Consideraciones finales:  El mayor conocimiento de la relación riesgosa entre periodontitis crónica e infarto cerebral isquémico, permitiría una utilización racional de estrategias de prevención y tratamiento de la enfermedad cerebrovascular, basadas en la detección de procesos inflamatorios como las periodontopatías crónicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  True periodontal pockets are an important reservoir of gram-negative bacteria which may exert an influence on distant sites in a variety of manners, bringing about systemic alterations such as diseases derived from atherosclerosis.  Objective:  Explain the theoretical foundations supporting the proposal of chronic periodontitis as a risk factor for ischemic stroke.  Content: 1) Atherosclerosis and cerebrovascular disease, an overview of their pathogenesis. 2) The periodontal microbiota, bases for its association with atherosclerosis and ischemic stroke  Topic presentation:  Inflammation is an element of vital importance in all the stages of the atherosclerotic process, be it its onset, progress or complications. By their nature, chronic immunoinflammatory periodontal diseases and the associated anaerobic subgingival infection, constitute a metastatic injury that produces and spreads inflammatory mediators leading to atherosclerosis and participating in the colonization and rupture of atheromatous plaques, which are processes involved in the pathogenesis of ischemic stroke.  Final considerations:  Better knowledge about the risk relationship between chronic periodontitis and ischemic stroke would allow a rational use of strategies for the prevention and treatment of cerebrovascular disease based on detection of inflammatory processes such as chronic periodontal conditions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedad periodontal]]></kwd>
<kwd lng="es"><![CDATA[periodontitis]]></kwd>
<kwd lng="es"><![CDATA[enfermedad cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[infarto cerebral]]></kwd>
<kwd lng="en"><![CDATA[periodontal disease]]></kwd>
<kwd lng="en"><![CDATA[periodontitis]]></kwd>
<kwd lng="en"><![CDATA[cerebrovascular disease]]></kwd>
<kwd lng="en"><![CDATA[cerebral infarction]]></kwd>
</kwd-group>
</article-meta>
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