<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev cubana med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232020000300006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Seguridad de la cloroquina y la hidroxicloroquina para el tratamiento de pacientes con COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Safety of chloroquine and hydroxychloroquine for treating COVID-19 patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Venegas]]></surname>
<given-names><![CDATA[Elia de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-García]]></surname>
<given-names><![CDATA[Omar Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Denis Piedra]]></surname>
<given-names><![CDATA[Daniel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad de Ciencias Médicas Finlay Albarrán ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>59</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232020000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232020000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232020000300006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La cloroquina y su análogo hidroxicloroquina han mostrado presentar efectos antivirales y antiinflamatorios, por lo que podría ser una alternativa de tratamiento ante el nuevo coronavirus SARS-CoV-2.  Objetivo:  Describir seguridad de la cloroquina e hidroxicloroquina para el tratamiento de la COVID-19 según la evidencia científica actual.  Método:  Se empleó la estrategia de búsqueda coronavirus OR COVID-19 OR SARS-CoV2 AND Cloroquina AND Hidroxicloroquina y se utilizaron las bases de datos Pubmed, SciELO, Lilacs, Cochrane Library y Web of Science. Se obtuvo un total de 32 referencias bibliográficas, seleccionándose a partir de criterios de selección.  Conclusiones:  La eficacia de la cloroquina y la hidroxicloroquina no ha sido probada del todo, pues los resultados no han sido concluyentes y se ha encontrado diferencias entre ellos, además de que no se han estudiado muestras suficientemente representativas. Las reacciones adversas de este medicamento, siendo las cardiovasculares las más peligrosas, no se deben ignorar ya que se han presentado con cierta frecuencia y en relación con la dosis administrada. Por ello, es necesario la realización de más ensayos clínicos aleatorizados, con mayor control de sesgos y muestras representativas, que evalúen la eficacia y seguridad de este medicamento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Chloroquine and its analogue hydroxychloroquine have shown antiviral and anti-inflammatory effects, so it could be an alternative treatment to the new SARS-CoV-2 coronavirus.  Objective:  To describe the safety of chloroquine and hydroxychloroquine for treating COVID-19 according to current scientific evidence.  Method:  We used the search strategy for coronavirus OR COVID-19 OR SARS-CoV2 AND Chloroquine AND Hydroxychloroquine, and Pubmed, SciELO, Lilacs, Cochrane Library and Web of Science databases were used. Thirty two bibliographic references were recovered, selection followed the selection criteria.  Conclusions:  The efficacy of chloroquine and hydroxychloroquine has not been fully proven, since the results have not been conclusive and differences have been found between them, In addition to the fact that sufficiently representative samples have not been studied. The adverse reactions of these drugs, and the cardiovascular ones are the most dangerous, should not be ignored since they have occurred with certain frequency and in relation to the administered dose. Therefore, it is necessary to carry out more randomized clinical trials, with greater control of biases and representative samples, to evaluate the efficacy and safety of these drugs.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[coronavirus]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[cloroquina]]></kwd>
<kwd lng="es"><![CDATA[hidroxicloroquina]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[coronavirus]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[chloroquine]]></kwd>
<kwd lng="en"><![CDATA[hydroxychloroquine]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
</kwd-group>
</article-meta>
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