<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev cubana med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232021000100012</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nuevos aspectos moleculares y fisiopatológicos de la anemia drepanocítica]]></article-title>
<article-title xml:lang="en"><![CDATA[New molecular and pathophysiological aspects of sickle cell anemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soler Noda]]></surname>
<given-names><![CDATA[Gilberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escalona Muñoz]]></surname>
<given-names><![CDATA[Lilia Zenaida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña Leyva]]></surname>
<given-names><![CDATA[Kirenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Hematología e Inmunología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Pediátrico Docente "William Soler"  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad de Tecnología de la Salud ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>60</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232021000100012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232021000100012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232021000100012&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La enfermedad por hemoglobina S es una anemia hemolítica crónica hereditaria cuyas manifestaciones clínicas provienen de la tendencia de esta hemoglobina de polimerizar y deformar los eritrocitos dándoles la típica forma de media luna, platanito, drepanocitos o "sickle cell"; de aquí el nombre de anemia drepanocítica o sicklemia. Objetivo: Describir los nuevos aspectos moleculares, fisiopatológicos y el diagnóstico de la anemia drepanocítica.  Métodos:  Se realizó una revisión de la literatura, en inglés y español, a través del sitio web PubMed y el motor de búsqueda Google académico de artículos publicados en los últimos 10 años. Se hizo un análisis y resumen de la bibliografía revisada.  Conclusiones:  La comprensión de la complejidad y multiplicidad de eventos que conducen a complicaciones graves en la anemia drepanocítica y nuestra incapacidad para predecir el curso clínico en cada caso particular ayudaría en la prevención de estos eventos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Hemoglobin S disease is a hereditary chronic hemolytic anemia whose clinical manifestations come from the tendency of this hemoglobin to polymerize and deform erythrocytes, giving the typical crescent, banana, sickle cell or "sickle cell" shape; hence the name sickle cell anemia or sicklemia.  Objective:  To describe the new molecular and pathophysiological aspects and the diagnosis of sickle cell anemia.  Methods:  A literature review was carried out, in English and Spanish, through PubMed website and Google academic search engine for articles published in the last 10 years. An analysis and summary of the revised bibliography was made.  Conclusions:  Understanding the complexity and multiplicity of events that lead to serious complications in sickle cell anemia and our inability to predict the clinical course in each particular case would help preventing these events.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hemoglobinopatías]]></kwd>
<kwd lng="es"><![CDATA[HbS]]></kwd>
<kwd lng="es"><![CDATA[anemia drepanocítica]]></kwd>
<kwd lng="es"><![CDATA[sicklemia]]></kwd>
<kwd lng="es"><![CDATA[hemoglobinas anormales]]></kwd>
<kwd lng="en"><![CDATA[hemoglobinopathies]]></kwd>
<kwd lng="en"><![CDATA[HbS]]></kwd>
<kwd lng="en"><![CDATA[Sickle-cell anaemia]]></kwd>
<kwd lng="en"><![CDATA[sicklemia]]></kwd>
<kwd lng="en"><![CDATA[abnormal hemoglobins]]></kwd>
</kwd-group>
</article-meta>
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