<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev cubana med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232021000400011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Manifestaciones extrarticulares y anticuerpos contra péptidos cíclicos citrulinados en artritis reumatoide]]></article-title>
<article-title xml:lang="en"><![CDATA[Extrarticular manifestations and antibodies against citrullinated cyclic peptides in rheumatoid arthritis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chico Capote]]></surname>
<given-names><![CDATA[Araceli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bertoli González]]></surname>
<given-names><![CDATA[Liset]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estévez del Toro]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kokuina]]></surname>
<given-names><![CDATA[Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casas Figueredo]]></surname>
<given-names><![CDATA[Nelsa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Bruzón]]></surname>
<given-names><![CDATA[Yeniset]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico &#8220;Hermanos Ameijeiras&#8221;  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>60</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232021000400011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232021000400011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232021000400011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La artritis reumatoide se manifiesta como enfermedad inflamatoria sistémica presenta manifestaciones extrarticulares.  Objetivos:  Determinar la frecuencia de manifestaciones extrarticulares en pacientes con artritis reumatoide, identificar las más frecuentes y su asociación con anticuerpos contra péptidos cíclicos citrulinados.  Métodos:  Se realizó un estudio descriptivo y transversal, en 101 pacientes con diagnóstico de artritis reumatoide, atendidos en La Consulta Protocolizada del Servicio de Reumatología del Hospital Clínico Quirúrgico &#8220;Hermanos Ameijeiras&#8221;, entre agosto y diciembre del año 2019. Se identificaron características sociodemográficas como edad, sexo, tiempo de evolución de la artritis reumatoide y tabaquismo. Se buscaron presencia de manifestaciones extrarticulares por el interrogatorio, examen físico y con ayuda de exámenes complementarios y se determinaron los títulos de anticuerpos contra péptidos cíclicos citrulinados en el plasma de los pacientes.  Resultados:  Las manifestaciones extrarticulares estuvieron presentes en 38 pacientes para 37,6 % de los casos, las más frecuentes fueron los nódulos subcutáneos 37 pacientes, y la anemia en 35 que constituyen 36,6 % y 34,7 % de los casos, respectivamente. Fueron positivos a antipéptidos cíclicos citrulinados 78 enfermos, 77,2 % de la muestra, no existió asociación entre presencia de los antipéptidos cíclicos citrulinados y la actividad de la enfermedad. No existió asociación significativa entre estos anticuerpos y las manifestaciones extrarticulares p&lt;0,0001. Fue significativa la asociación entre los niveles de antipéptidos cíclicos citrulinados y el número de manifestaciones extrarticulares en un paciente p=0,0018.  Conclusiones:  Las manifestaciones articulares existentes en los pacientes estudiados se asociaron, significativamente, con la presencia de los antipéptidos cíclicos citrulinados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Rheumatoid arthritis within its expression as a systemic inflammatory disease presents extra-articular manifestations.  Objectives:  To determine the frequency of extra-articular manifestations in patients with rheumatoid arthritis, to identify the most frequent and their association with antibodies against citrullinated cyclic peptides.  Methods:  A descriptive and cross-sectional study was carried out in 101 patients with a diagnosis of rheumatoid arthritis, assisted in the protocolized consultation of Rheumatology service at Hermanos Ameijeiras Clinical Surgical Hospital, from August to December 2019. Sociodemographic characteristics were identified, such as age, sex, time of evolution of rheumatoid arthritis, smoking habits. The presence of extra-articular manifestations was searched for by questioning, physical examination and with the help of complementary tests, and the titers of antibodies against citrullinated cyclic peptides were determined in the plasma of the patients.  Results:  Extra-articular manifestations were present in 38 patients, 37.6% of the cases, the most frequent were subcutaneous nodules in 37 patients, and anemia in 35, which constituted 36.6% and 34.7% of the cases, respectively. Seventy eight patients were positive for citrullinated cyclic antipeptides, 77.2% of the sample, there was no association between the presence of citrullinated cyclic antipeptides and the activity of the disease. There was no significant association between the presence of these antibodies and the presence of extra-articular manifestations p &lt;0.0001, the association between the levels of citrullinated cyclic antipeptides and the number of extra-articular manifestations in a patient was significant p=0.0018.  Conclusions:  The existing joint manifestations in the studied patients were significantly associated with the presence of citrullinated cyclic antipeptides.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[artritis reumatoide]]></kwd>
<kwd lng="es"><![CDATA[manifestaciones extrarticulares]]></kwd>
<kwd lng="es"><![CDATA[péptidos cíclicos citrulinados]]></kwd>
<kwd lng="en"><![CDATA[rheumatoid arthritis]]></kwd>
<kwd lng="en"><![CDATA[extra-articular manifestations]]></kwd>
<kwd lng="en"><![CDATA[citrullinated cyclic peptides]]></kwd>
</kwd-group>
</article-meta>
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