<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Cuban de Med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232023000400013</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Restricción de líquidos en pacientes con sepsis]]></article-title>
<article-title xml:lang="en"><![CDATA[Fluid Restriction in Patients with Sepsis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cárdenas-Ponce]]></surname>
<given-names><![CDATA[Jorge Luís]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Panimbosa-Llamuca]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rocha-Ramírez]]></surname>
<given-names><![CDATA[Paúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Ambato  ]]></institution>
<addr-line><![CDATA[ Ambato]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Ecuatoriano de Seguridad Social  ]]></institution>
<addr-line><![CDATA[ Ambato]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Técnica de Ambato Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[ Ambato]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Regional Autónoma de los Andes Facultad de Ciencias Médicas ]]></institution>
<addr-line><![CDATA[ Ambato]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>62</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232023000400013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232023000400013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232023000400013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La sepsis es una respuesta inflamatoria del cuerpo a una infección. En la actualidad continúa como una causa importante de morbimortalidad en todo el mundo. La administración temprana de líquidos es una estrategia fundamental en el manejo de la sepsis. Sin embargo, la cantidad y el tipo de líquidos administrados en pacientes con sepsis es aún objeto de debate.  Objetivo:  Evaluar los resultados de ensayos clínicos aleatorios para una comprensión más profunda de la efectividad de la restricción de líquidos en pacientes con sepsis.  Métodos:  Se realizó una búsqueda sistemática en diferentes bases de datos para realizar una evaluación crítica acerca de los artículos incluidos, se utilizaron las herramientas de evaluación de riesgo de sesgo cochrane y análisis de datos.  Resultados:  Se incluyeron 13 ensayos clínicos aleatorios controlados que compararon la restricción de líquidos versus la administración de líquidos en pacientes adultos con sepsis.  Conclusiones:  Se encontró que la restricción de líquidos se asoció con una reducción en la mortalidad y un menor número de días de soporte respiratorio y cardiovascular en pacientes con sepsis. Sin embargo, algunos estudios no encontraron diferencias significativas en la mortalidad entre la restricción de líquidos y la administración de líquidos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Sepsis is an inflammatory response of the body to an infection. Currently it continues as a major cause of morbidity and mortality worldwide. Early fluid administration is a fundamental strategy in the management of sepsis. However, the amount and type of fluids administered in patients with sepsis is still a matter of debate.  Objective: To evaluate the results of randomized clinical trials for a deeper understanding of the effectiveness of fluid restriction in patients with sepsis.  Methods:  A systematic search was carried out in different databases to carry out a critical evaluation of the included articles, the Cochrane risk of bias assessment tools and data analysis were used.  Results: Thirteen randomized controlled trials were included, which compared fluid restriction versus fluid administration in adult patients with sepsis.  Conclusions:  We found that fluid restriction was associated with a reduction in mortality and a lower number of days of respiratory and cardiovascular support in patients with sepsis. However, some studies found no significant difference in mortality between fluid restriction and fluid administration.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[líquidos]]></kwd>
<kwd lng="es"><![CDATA[restricción]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[liquids]]></kwd>
<kwd lng="en"><![CDATA[restriction]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
</kwd-group>
</article-meta>
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