<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7531</journal-id>
<journal-title><![CDATA[Revista Cubana de Pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Pediatr]]></abbrev-journal-title>
<issn>0034-7531</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75312018000400005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Respuesta al tratamiento radioterápico en pacientes con tumores malignos de cabeza y cuello]]></article-title>
<article-title xml:lang="en"><![CDATA[Response to radiotherapy treatment in patients with head and neck malignant tumors]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Verdecia Cañizares]]></surname>
<given-names><![CDATA[Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alonso Pírez]]></surname>
<given-names><![CDATA[Magda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alert Silva]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lam Díaz]]></surname>
<given-names><![CDATA[Rosa María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Pediátrico Universitario &#8220;William Soler&#8221; Servicio de Oncocirugía ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Oncología y Radiobiología Servicio de Radioterapia ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Hematología e Inmunología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>90</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75312018000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75312018000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75312018000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La radioterapia es una de las variantes de tratamiento más antiguas con que contamos hoy día para curar los pacientes afectos de neoplasias malignas, pero debe ser cuidadosamente seleccionada en pacientes pediátricos.  Objetivo:  Evaluar la respuesta al tratamiento radiante en niños con tumores de cabeza y cuello.  Métodos:  Se realizó un estudio descriptivo, retrospectivo lineal, donde se incluyeron 26 pacientes ingresados en el Servicio de Oncocirugía del hospital &#8220;William Soler&#8221; desde enero de 2000 a enero de 2013, con diferentes tipos de tumores malignos de cabeza y cuello y edades comprendidas entre 1 y 18 años. Se tuvieron en cuenta los efectos tóxicos a largo plazo del tratamiento radiante, asociado o no a tratamiento quimioterápico adyuvante o concurrente y a la cirugía.  Resultados: Todos los pacientes recibieron radioterapia corporal externa, el 73,1 % de los casos recibió quimioterapia adyuvante en su mayoría con diagnóstico de linfomas y 7,7 % recibió quimioterapia concurrente. Esta última en dos pacientes: uno con sarcoma facial y otro con carcinoma de parótida. Cinco pacientes (19,2 %) solo recibieron cirugía y radioterapia como tratamiento: dos casos con neuroblastoma, un caso con sarcoma facial y dos con hemangiopericitomas.  Conclusión:  El estudio demostró la gran utilidad del empleo de la radioterapia en el control de las enfermedades malignas de la infancia localizadas en cabeza y cuello.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Radiotherapy is one of the oldest treatments used nowadays for curing patients suffering from malignant neoplasias, but it must be carefully selected in pediatric patients.  Objective:  To evaluate the response of radiotherapy treatments in children with head and neck tumors.  Methods:  A descriptive, lineal retrospective study was carried out, in which were included 26 patients admitted in the Service of Oncosurgery of &#8220;William Soler&#8221; Hospital from January, 2000 to January, 2013. These patients presented different kinds of head and neck malignant tumors; their ages were among 1 and 18 years. The long term toxic effects of radiotherapy were taken into account, being those associated or not to concurrent or adyuvant chemotherapy, and to surgery.  Results: All the patients received physical external radiotherapy. 73,1 % of the cases (most of them with a diagnosis of lymphoma) received adyuvant chemotherapy and 7,7 % had concurrent chemotherapy. This last one in two patients: one with facial sarcoma and the other one with parotid carcinoma. Just five patients (19.2 %) had surgery and radiotherapy as treatment: two cases with neuroblastoma, one case with facial sarcoma, and two cases of hemangiopericytomas.  Conclusions:  This study has demonstrated the usefulness of radiotherapy in the control of head and neck malignant diseases in children.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[radioterapia]]></kwd>
<kwd lng="es"><![CDATA[tumores de cabeza y cuello]]></kwd>
<kwd lng="es"><![CDATA[pediatría]]></kwd>
<kwd lng="en"><![CDATA[radioteraphy]]></kwd>
<kwd lng="en"><![CDATA[head and neck tumors]]></kwd>
<kwd lng="en"><![CDATA[pediatrics]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[NN]]></given-names>
</name>
<name>
<surname><![CDATA[Ting]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[WC]]></given-names>
</name>
<name>
<surname><![CDATA[Lui]]></surname>
<given-names><![CDATA[LT]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of magnetic resonance imaging versus CT on nasopharyngeal carcinoma primary tumor target delineation for radiotherapy]]></article-title>
<source><![CDATA[Head Neck]]></source>
<year>2004</year>
<volume>26</volume>
<page-range>241-6</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alert]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Empleo del tratamiento radiante en los tumores de cabeza y cuello en el niño (parte I tumores malignos)]]></article-title>
<source><![CDATA[Rev Cubana Oncol]]></source>
<year>2001</year>
<volume>17</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>200-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hitt]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Tumores cabeza y cuello. ORL]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hitt]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Efectos secundarios a largo plazo en tratamiento del cáncer. ASCO]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spycher]]></surname>
<given-names><![CDATA[BD]]></given-names>
</name>
<name>
<surname><![CDATA[Lupatsch]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Zwahlen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Röösli]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Niggli]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Grotzer]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Background ionizing radiation and the risk of childhood cancer a census-based nationwide cohort study: Environ]]></article-title>
<collab>Swiss Pediatric Oncology Group</collab>
<source><![CDATA[Health]]></source>
<year>2015</year>
<volume>123</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>622-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wohlleben]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Scherzad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Güttler]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vordermark]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kuger]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Flentje]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influence of hypoxia and irradiation on osteopontin expression in head and neck cancer and glioblastoma cell lines]]></article-title>
<source><![CDATA[Radiat Oncol]]></source>
<year>2015</year>
<volume>10</volume>
<page-range>167</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Qin]]></surname>
<given-names><![CDATA[YT]]></given-names>
</name>
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[ZX]]></given-names>
</name>
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sp1 is over-expressed in nasopharyngeal cancer and is a poor prognostic indicator for patients receiving radiotherapy]]></article-title>
<source><![CDATA[Int J Clin Exp Pathol]]></source>
<year>2015</year>
<volume>8</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>6936-43</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gatta]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Zigons]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Capocaccia]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Coebergh]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Desandes]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Kaatsch]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Survival of european children and young adults with cancer diagnosed 1995-2002]]></article-title>
<source><![CDATA[Eur J Cancer]]></source>
<year>2009</year>
<volume>45</volume>
<page-range>992-1005</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McBride]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Daganzo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Banerjee]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lamborn]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Prudor]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumors]]></article-title>
<source><![CDATA[Int J Radiat Oncol Biol Phys]]></source>
<year>2008</year>
<volume>72</volume>
<page-range>1349-23</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hudgins]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Kingdom]]></surname>
<given-names><![CDATA[TT]]></given-names>
</name>
<name>
<surname><![CDATA[Weissler]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Selective Neck dissection CT and MR imaging findings]]></article-title>
<source><![CDATA[AJNR]]></source>
<year>2005</year>
<volume>26</volume>
<page-range>1174-7</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mack]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Balzer]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<name>
<surname><![CDATA[Straub]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Eichler]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vogl TJ- Supermara magnetic Iron Oxide enhanced MR Imaging of Head and Neck Lymph Nodes]]></article-title>
<source><![CDATA[Radiology]]></source>
<year>2002</year>
<volume>222</volume>
<page-range>239-44</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fukui]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Blodgett]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Snyderman]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Combined PET-CT in the Head and Neck Part I: Diagnostic Uses and pitfalls of oncologic imaging]]></article-title>
<source><![CDATA[Radiographics]]></source>
<year>2005</year>
<volume>25</volume>
<page-range>913-30</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liao]]></surname>
<given-names><![CDATA[CT]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[JTC]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
<name>
<surname><![CDATA[Hsueh]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[LY]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[SF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of risk factors of predictive local tumor control in oral cavity cancer]]></article-title>
<source><![CDATA[Ann Surg Oncol]]></source>
<year>2008</year>
<volume>15</volume>
<page-range>915-22</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moran Guasch]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[León]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Recher]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Gras Cabrerizo]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Bergés Bueno]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tumores de las partes blandas de Cabeza y Cuello]]></article-title>
<collab>IM&amp;C, SA</collab>
<source><![CDATA[Manual del Residente de ORL y Patología Cérvico-Facial]]></source>
<year>2002</year>
<publisher-loc><![CDATA[Barcelona ]]></publisher-loc>
<publisher-name><![CDATA[IM&amp;C, SA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zumsteg]]></surname>
<given-names><![CDATA[ZS]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Tighiouart]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Shiao]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of concomitant chemoradiation on survival for patients with T1-2N1 head and neck cancer]]></article-title>
<source><![CDATA[Cancer]]></source>
<year>2017</year>
<volume>123</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1555-65</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Budach]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Stromberger]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Poettgen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hyperfractionated accelerated Radiation therapy (HART) of 70 6 Gy with concurrent 5-FU/mitomycin C is superior to HART of 77.6 Gy alone in locally advanced head and neck cancer: long-term results of the AR0 95-06 randomized phase III trial]]></article-title>
<source><![CDATA[Int J Radiat Oncol Biol Phys]]></source>
<year>2015</year>
<volume>91</volume>
<page-range>916-24</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
