<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7531</journal-id>
<journal-title><![CDATA[Revista Cubana de Pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Pediatr]]></abbrev-journal-title>
<issn>0034-7531</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75312021000400004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Biomarcadores en la sepsis y su valor predictivo en pacientes pediátricos]]></article-title>
<article-title xml:lang="en"><![CDATA[Biomarkers in Sepsis and Their Predictive Value in Pediatric Patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Francisco Pérez]]></surname>
<given-names><![CDATA[Julio César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Llerena Mesa]]></surname>
<given-names><![CDATA[María de las Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piedra Garcés]]></surname>
<given-names><![CDATA[Mileny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Concepción Pérez]]></surname>
<given-names><![CDATA[Elibet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno Guerra]]></surname>
<given-names><![CDATA[Yuslei]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lescay Vizcaya]]></surname>
<given-names><![CDATA[Ayme]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Hospital Pediátrico &#8220;Borrás Marfán ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Hospital Militar &#8220;Luis Díaz Soto ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Facultad de Ciencias médicas de Artemisa  ]]></institution>
<addr-line><![CDATA[ Artemisa]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Hospital Pediátrico Universitario &#8220;William Soler&#8221; ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>93</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75312021000400004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75312021000400004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75312021000400004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La sepsis en niños, es causa de gran preocupación entre los pediatras. La incorporación de nuevos biomarcadores posibilita la obtención de un diagnóstico rápido y preciso.  Objetivo: Determinar la capacidad predictiva de mortalidad de un grupo de biomarcadores en pacientes pediátricos con sepsis.  Métodos: Estudio multicéntrico descriptivo analítico, prospectivo y longitudinal en 60 pacientes ingresados en dos Unidades de cuidados intensivos: Hospital Dediátrico docente &#8220;Borrás-Marfán&#8221; y Hospital Pediátrico Universitario &#8220;William Soler&#8221; entre diciembre de 2016 y diciembre de 2018, con diagnóstico de sepsis severa y shock séptico. Se caracterizó la muestra según variables demográficas, origen y estadios de la sepsis y mortalidad; además se determinaron los biomarcadores más sensibles para el diagnóstico inicial y de mejor valor predictivo. Se empleó la estadística descriptiva y se realizaron pruebas diagnósticas con más de dos resultados (curva ROC).  Resultados: Se observó una distribución similar de la muestra en cuanto sexo, con una media edad promedio de 5 años; dos tercios se diagnosticaron como sepsis graves y 23,3 % falleció El lactato fue el marcador con mayor sensibilidad.  Conclusiones: Los biomarcadores más sensibles para el diagnóstico inicial de la sepsis fueron: lactato, proteína C reactiva y velocidad de sedimentación globular; los dos primeros junto a los leucocitos, neutrófilos y plaquetas, también resultaron buenos predictores de mortalidad. La velocidad de sedimentación globular fue el biomarcador predictor de mortalidad menos significativo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Sepsis in children is a cause of great concern among pediatricians. New biomarkers makes it possible to obtain quick and accurate diagnosis.  Objective:  To determine the predictive capacity of mortality of a group of biomarkers in pediatric patients with sepsis.  Methods: An analytical, prospective and longitudinal descriptive multicenter study was carried out in 60 patients admitted to two intensive care units at Borrás-Marfán Teaching Pediatric Hospital and William Soler University Pediatric Hospital from December 2016 to December 2018. These patients had a diagnosis of sepsis severe and septic shock. The sample was characterized according to demographic variables, origin and stages of sepsis and mortality. In addition, the most sensitive biomarkers for the initial diagnosis and the best predictive value were determined. Descriptive statistics were used and diagnostic tests were performed with more than two results (ROC curve).  Results:  A similar distribution of the sample was observed in terms of sex, with average age of 5 years; two thirds were diagnosed as severe sepsis and 23.3% died. Lactate was the marker with the highest sensitivity.  Conclusions:  The most sensitive biomarkers for the initial diagnosis of sepsis were lactate, C-reactive protein and erythrocyte sedimentation rate; the first two, together with leukocytes, neutrophils, and platelets, were also good predictors of mortality. Erythrocyte sedimentation rate was the least significant predictor of mortality biomarker.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[shock séptico]]></kwd>
<kwd lng="es"><![CDATA[biomarcador]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[biomarker]]></kwd>
</kwd-group>
</article-meta>
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