<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7531</journal-id>
<journal-title><![CDATA[Revista Cubana de Pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Pediatr]]></abbrev-journal-title>
<issn>0034-7531</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75312021000500010</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tuberculosis infantil sistémica]]></article-title>
<article-title xml:lang="en"><![CDATA[Systemic childhood tuberculosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Neyra-León]]></surname>
<given-names><![CDATA[Jesús Andreé]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[De la Cruz-Chacaliaza]]></surname>
<given-names><![CDATA[Nicolas]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jorge-Fernández]]></surname>
<given-names><![CDATA[Dalma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdivia-Heredia]]></surname>
<given-names><![CDATA[Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Privada San Juan Bautista Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ Ica]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Asociación de Investigación y Ciencia Universidad Privada San Juan Bautista ]]></institution>
<addr-line><![CDATA[ Ica]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Regional de Ica Departamento de Pediatría ]]></institution>
<addr-line><![CDATA[ Ica]]></addr-line>
<country>Perú</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>93</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75312021000500010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75312021000500010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75312021000500010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La tuberculosis infantil, definida como la enfermedad infectocontagiosa producida por el bacilo de Koch en pacientes menores de 15 años, continúa siendo un problema de salud pública debido a la cantidad de casos que anualmente se informan, además de ser un desafío para el pediatra en el diagnóstico y tratamiento de esta enfermedad.  Objetivo:  Describir el caso de un paciente varón con un cuadro de tuberculosis multisistémica.  Presentación de caso:  Paciente varón de 13 años con un cuadro progresivo de pérdida de peso de 20 kilos en 3 meses, dolor abdominal de localización difusa, tos seca e hiporexia. En los exámenes realizados, se encontraron lesiones cavitarias pulmonares, múltiples adenopatías enteroperitoneales y baciloscopia positiva en heces y orina; con lo que se llegó al diagnóstico de tuberculosis sistémica infantil y se inició esquema antituberculoso. El paciente evolucionó favorablemente y se encuentra estable.  Conclusiones: Ante un paciente pediátrico con síndrome consuntivo, procedente de una zona endémica, la tuberculosis debe ser una de las primeras opciones en el diagnóstico diferencial.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Childhood tuberculosis, defined as the infectious-contagious disease caused by the Koch bacillus in patients under 15 years of age, continues to be a public health problem due to the number of cases that are reported annually; in addition to represent a challenge for the pediatrician in the diagnosis and treatment of this disease.  Objective:  Describe the case of a male patient with a picture of multisystem tuberculosis.  Case presentation:  A 13-year-old male patient with a progressive weight loss of 20 kg in 3 months, abdominal pain of diffuse location, dry cough and hyporexia. In the examinations carried out, pulmonary cavitary lesions, multiple enteroperitoneal adenopathies and positive smears in feces and urine were found; with which the diagnosis of systemic tuberculosis in children was reached and an antituberculous scheme was initiated. The patient progressed favorably and he is stable.  Conclusions:  In the case of a pediatric patient with a wasting syndrome, and coming from an endemic area, tuberculosis should be one of the first options in the differential diagnosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[mycobacterium tuberculosi]]></kwd>
<kwd lng="es"><![CDATA[tuberculosis gastrointestinal]]></kwd>
<kwd lng="es"><![CDATA[adolescente]]></kwd>
<kwd lng="en"><![CDATA[Tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[mycobacterium tuberculosi]]></kwd>
<kwd lng="en"><![CDATA[gastrointestinal tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[adolescent]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Pirez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Childhood tuberculosis: a clinical case of a typical presentation]]></article-title>
<source><![CDATA[Arch Pediatr Urog]]></source>
<year>2015</year>
<volume>86</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>30-4</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parra]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pediatric tuberculosis]]></article-title>
<source><![CDATA[Bol Med Hosp Infant Mex]]></source>
<year>2017</year>
<volume>74</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-2</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Becerra]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Olivera]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Quiroz]]></surname>
<given-names><![CDATA[TV]]></given-names>
</name>
<name>
<surname><![CDATA[Guedez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Branco]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical and epidemiological features of tuberculosis in children and adolescents]]></article-title>
<source><![CDATA[Rev Bras Enferm]]></source>
<year>2019</year>
<volume>72</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1271-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kimberlin]]></surname>
<given-names><![CDATA[DW]]></given-names>
</name>
<name>
<surname><![CDATA[Barnett]]></surname>
<given-names><![CDATA[ED]]></given-names>
</name>
<name>
<surname><![CDATA[Lynfield]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sawyer]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
</person-group>
<source><![CDATA[Red Book: 2021-2024 Report of the Committee on Infectious Diseases]]></source>
<year>2021</year>
<edition>32va</edition>
<publisher-loc><![CDATA[Itasca, IL ]]></publisher-loc>
<publisher-name><![CDATA[American Academy of Pediatrics]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Faddoul]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Childhood Tuberculosis, an overview]]></article-title>
<source><![CDATA[Adv Pediatr (Canada)]]></source>
<year>2015</year>
<volume>62</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>59-90</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vázquez]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Acosta]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Miranda]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Fuentes]]></surname>
<given-names><![CDATA[YC]]></given-names>
</name>
<name>
<surname><![CDATA[Labra]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[DO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case-series analysis of tuberculosis in pediatric patients treated in a tertiary level hospital]]></article-title>
<source><![CDATA[Bol Med. Hosp. Infant. Mex]]></source>
<year>2017</year>
<volume>74</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-33</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Cardoso]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Martire]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Battista]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Couto]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aspectos epidemiológicos, manifestaciones clínicas y prevención de la tuberculosis pediátrica desde la perspectiva de la estrategia End TB]]></article-title>
<source><![CDATA[J Bras Pneumol Sao Paulo]]></source>
<year>2018</year>
<volume>44</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>134-44</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rubiano]]></surname>
<given-names><![CDATA[YLM]]></given-names>
</name>
<name>
<surname><![CDATA[Puerto]]></surname>
<given-names><![CDATA[AHG]]></given-names>
</name>
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tuberculosis infantil: una revisión narrativa de la literatura]]></article-title>
<source><![CDATA[Investigac Andinas (Colombia)]]></source>
<year>2016</year>
<volume>18</volume>
<numero>32</numero>
<issue>32</issue>
<page-range>1455-79</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alarcón]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Alarcón]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Figueroa]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tuberculosis en el Perú: situación epidemiológica, avance y desafíos para su control]]></article-title>
<source><![CDATA[Rev Peruana Med. Exp Salud Pública]]></source>
<year>2017</year>
<volume>34</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Furín]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Advances in the diagnosis, treatment, and prevention of tuberculosis in children]]></article-title>
<source><![CDATA[Expert Rev Respirator Med]]></source>
<year>2019</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>301-11</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shingadia]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tuberculosis in childhood]]></article-title>
<source><![CDATA[Therapeutic Adv Respiratoyr Dis]]></source>
<year>2012</year>
<volume>6</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>161-71</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Lee Meijuan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Loh]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
<name>
<surname><![CDATA[Thoon]]></surname>
<given-names><![CDATA[KC]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[NWH]]></given-names>
</name>
<name>
<surname><![CDATA[Chong]]></surname>
<given-names><![CDATA[CY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pediatric Abdominal Tuberculosis in Singapore: A 10-Year Retrospective Series]]></article-title>
<source><![CDATA[Glob Pediatr Health]]></source>
<year>2020</year>
<volume>7</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rathi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gambhire]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Abdominal Tuberculosis]]></article-title>
<source><![CDATA[J Assoc Physicians (India)]]></source>
<year>2016</year>
<volume>64</volume>
<page-range>38</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Figueiredo]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Lucon]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Urogenital tuberculosis: update and review of 8961 cases from the world literature]]></article-title>
<source><![CDATA[Rev Urol]]></source>
<year>2008</year>
<volume>10</volume>
<page-range>207</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muneer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Macrae]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Krishnamoorthy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zumla]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Urogenital tuberculosis-epidemiology, pathogenesis and clinical features]]></article-title>
<source><![CDATA[Nat Rev Urol]]></source>
<year>2019</year>
<volume>16</volume>
<page-range>573-98</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<collab>MINSA Perú</collab>
<source><![CDATA[Norma técnica de salud para la atención integral de las personas afectadas por tuberculosis; aprobada por R.M.N 752-2018/MINSA]]></source>
<year>2018</year>
<publisher-loc><![CDATA[Perú ]]></publisher-loc>
<publisher-name><![CDATA[Ministerio de salud]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Bravo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[linical and epidemiological features of tuberculosis in children and adolescents]]></article-title>
<source><![CDATA[Rev Bras Enfermer (Brasilia)]]></source>
<year>2019</year>
<volume>72</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1271-8</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duke]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kasa Tom]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Poka]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Welch]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Holistic care of complicated tuberculosis in healthcare settings with limited resources]]></article-title>
<source><![CDATA[Arch Dis Child]]></source>
<year>2017</year>
<volume>102</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1161-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
