<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0138-6557</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Militar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Med Mil]]></abbrev-journal-title>
<issn>0138-6557</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0138-65572022000100004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La edad como variable asociada a la gravedad en pacientes con la COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Age as a variable associated with severity in patients with COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera Cartaya]]></surname>
<given-names><![CDATA[Carlos Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lage Dávila]]></surname>
<given-names><![CDATA[Agustín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betancourt Cervantes]]></surname>
<given-names><![CDATA[Julio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barreto Fiu]]></surname>
<given-names><![CDATA[Eligio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Valdés]]></surname>
<given-names><![CDATA[Lizet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Claro]]></surname>
<given-names><![CDATA[Lilibeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Universitario &#8220;Arnaldo Milián Castro&#8221; Departamento de Medicina Intensiva ]]></institution>
<addr-line><![CDATA[ Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Militar &#8220;Comandante Manuel Fajardo Rivero&#8221; Departamento de Medicina Intensiva ]]></institution>
<addr-line><![CDATA[ Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro de Inmunología Molecular  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Ciencias Médicas Departamento de Bioestadística ]]></institution>
<addr-line><![CDATA[ Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>51</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0138-65572022000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0138-65572022000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0138-65572022000100004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La COVID-19, estremeció al mundo en diciembre de 2019. Desde sus inicios se ha observado que los pacientes de mayor edad son propensos a desarrollar formas graves de la enfermedad.  Objetivo: Determinar el papel de la edad como variable asociada a la gravedad en pacientes con la COVID-19.  Métodos:  Se realizó un estudio analítico retrospectivo de cohorte en 150 pacientes diagnosticados con la COVID-19, desde marzo hasta junio de 2020. Se analizó la gravedad según grupos de edades, mediante un modelo de regresión logística binaria simple. Fueron resumidas variables clínicas y de laboratorio al ingreso hospitalario, para la comparación de 2 grupos de edad a partir del punto de corte óptimo para la edad mediante la curva ROC. Se utilizó el software libre R versión 4.0.2 (22-06-2020) para el procesamiento.  Resultados : La edad de los pacientes tuvo un amplio rango; predominó la gravedad de la enfermedad en los grupos de edad avanzada. El punto de corte óptimo calculado fue 71,5; se observó que a partir de los 70 años los pacientes tenían mayor comorbilidad y pruebas de laboratorio alteradas. Igualmente, tuvieron mayor cantidad de síntomas, estadía hospitalaria y número de fallecidos.  Conclusiones:  La edad constituye un factor de riesgo asociado a la gravedad en pacientes con la COVID-19; aumenta significativamente a partir de los 70 años, cuando coexisten una serie de factores que, unidos a la edad avanzada, juegan un importante papel en el pronóstico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  COVID-19, rocked the world in December 2019. Since its inception, it has been observed that older patients are prone to develop severe forms of the disease.  Objective: To determine the role of age as a variable associated with severity in COVID-19 patients.  Methods:  A retrospective cohort analytical study was conducted in 150 patients diagnosed with COVID-19, during March to June 2020. The severity was analyzed according to age groups, and a simple binary logistic regression model was used. Clinical and laboratory variables at hospital admission were summarized for the comparison of two age groups from the optimal cut-off point for age using the ROC curve. The free software R version 4.0.2 (22-06-2020) was used for processing.  Results:  The age of the patients had a wide range, with disease severity predominating in the older age groups. The optimal cut-off point calculated was 71.5. Was observed that from 70 years of age onwards patients had greater comorbidity and altered laboratory tests. Likewise, a greater number of symptoms, hospital stay, and number of deaths.  Conclusions:  Age is a risk factor associated with severity in patients with COVID-19, which increases significantly after 70 years of age, where a series of factors coexist which, together with advanced age, play an important role in the prognosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[edad]]></kwd>
<kwd lng="es"><![CDATA[riesgo]]></kwd>
<kwd lng="es"><![CDATA[pronóstico]]></kwd>
<kwd lng="es"><![CDATA[comorbilidad]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[age]]></kwd>
<kwd lng="en"><![CDATA[risk]]></kwd>
<kwd lng="en"><![CDATA[prognosis]]></kwd>
<kwd lng="en"><![CDATA[comorbidity]]></kwd>
</kwd-group>
</article-meta>
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