<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0138-6557</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Militar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. cuban. med. mil.]]></abbrev-journal-title>
<issn>0138-6557</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0138-65572022000400013</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aspergilosis pulmonar crónica necrotizante]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic necrotizing pulmonary aspergillosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta Sánchez]]></surname>
<given-names><![CDATA[Dainer Rogelio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lastre Rubio]]></surname>
<given-names><![CDATA[Yarleti de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Molina]]></surname>
<given-names><![CDATA[Indira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez Sánchez]]></surname>
<given-names><![CDATA[Leordanys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Docente &#8220;Dr. Juan Bruno Zayas Alfonso&#8221;  ]]></institution>
<addr-line><![CDATA[ Santiago de Cuba]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Docente &#8220;Orlando Pantoja Tamayo&#8221;  ]]></institution>
<addr-line><![CDATA[ Santiago de Cuba]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>51</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0138-65572022000400013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0138-65572022000400013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0138-65572022000400013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La aspergilosis crónica necrotizante es una enfermedad infrecuente que se caracteriza por ser un proceso destructivo y crónico en el parénquima pulmonar. Se clasifica en cavitaria, necrotizante y fibrosante.  Objetivo: Presentar una paciente con aspergilosis crónica necrotizante, sus características clínicas, diagnósticas y procedimiento terapéutico empleado.  Caso clínico: Paciente femenina de 20 años de edad con antecedentes de asma bronquial que hace 6 meses presenta tos con expectoración amarrilla; realizó varios ciclos de antibióticos con poca mejoría clínica, un mes atrás comenzó con fiebre de 38 ºC, falta de aire y hemoptisis. Se ingresó en la sala de neumología con la sospecha de tuberculosis pulmonar o micosis pulmonar. Se estableció el diagnóstico definitivo de aspergilosis crónica necrotizante, a través de la tinción de Grocott y ácido peryódico de Schiff, los esputos micológicos y la tomografía axial computarizada. Se instauró tratamiento con anfotericina B liofilizada, por 21 días y luego itraconazol por vía oral, por 3 meses; la evolución fue satisfactoria.  Conclusiones: La sospecha clínica y la confirmación, tanto radiológica como micológica en todo paciente con manifestaciones clínicas de evolución insidiosa y escasa respuesta a los antibióticos, es fundamental para llegar al diagnóstico de aspergilosis pulmonar.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Chronic necrotizing aspergillosis is a rare disease that is characterized by being a destructive and chronic process in the lung parenchyma. It is classified as cavitary, necrotizing and fibrosing.  Objective:  To present a patient with chronic necrotizing aspergillosis, her clinical and diagnostic characteristics and the therapeutic procedure used.  Clinical case:  A 20-year-old female patient with a history of bronchial asthma who had a cough with yellow expectoration 6 months ago; she underwent several cycles of antibiotics with little clinical improvement, a month ago she started with a fever of 38 ºC, shortness of breath and hemoptysis. She was admitted to the pulmonology ward with suspected pulmonary tuberculosis or pulmonary mycosis. The definitive diagnosis of chronic necrotizing aspergillosis was established through Grocott and Schiff periodic acid staining, mycological sputum, and computerized axial tomography. Treatment with lyophilized amphotericin B was established for 21 days and then oral itraconazole for 3 months; the evolution was satisfactory.  Conclusions:  Clinical suspicion and confirmation, both radiological and mycological in all patients with clinical manifestations of insidious evolution and poor response to antibiotics, is essential to reach the diagnosis of pulmonary aspergillosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[aspergilosis crónica]]></kwd>
<kwd lng="es"><![CDATA[necrotizante]]></kwd>
<kwd lng="es"><![CDATA[micosis]]></kwd>
<kwd lng="es"><![CDATA[broncoscopia]]></kwd>
<kwd lng="en"><![CDATA[chronic aspergillosis]]></kwd>
<kwd lng="en"><![CDATA[necrotizing]]></kwd>
<kwd lng="en"><![CDATA[mycoses]]></kwd>
<kwd lng="en"><![CDATA[bronchoscopy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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