<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0253-570X</journal-id>
<journal-title><![CDATA[Revista de Salud Animal]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Salud Anim.]]></abbrev-journal-title>
<issn>0253-570X</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Sanidad Agropecuaria]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0253-570X2018000200009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Necrólisis Epidérmica canina Tóxica en perros. Reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Toxic Epidermal Necrolysis in dogs. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murcia-Marroquín]]></surname>
<given-names><![CDATA[Edgar Humberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camacho-Castro]]></surname>
<given-names><![CDATA[Aracely]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salcedo-Sánchez]]></surname>
<given-names><![CDATA[Hermes Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vaquiro-Rumique]]></surname>
<given-names><![CDATA[Angela Rocio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la Amazonia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Sanidad Animal UDCA  ]]></institution>
<addr-line><![CDATA[ Bogotá]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>40</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0253-570X2018000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0253-570X2018000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0253-570X2018000200009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Ingresa a consulta un canino mestizo de dos meses y medio de edad, pesando 3,5 kg, con pérdida de aproximadamente 60 % de piel a nivel toracolumbar y con compromiso del área perianal. Había sido tratado con anterioridad por presentar gastroenteritis hemorrágica, con fluidoterapia y antibiótico vía intravenosa (IV), (Solución Hartmann, Metronidazol) y Metoclopramida vía subcutánea (SC), durante los tres primeros días y mostró mejoría. Al cuarto día de tratamiento se le formaron ampollas en la piel a nivel dorsal, que luego rompieron dejando una gran solución de continuidad. Se aplicó Prednisolona, Trihidrato de Amoxicilina+Clavulanato de Potasio (Uniclav®), en dosis no presentadas en la Historia Clínica remitida, sin mejoría alguna. La lesión progresó hasta afectar la zona ventral, por lo cual la propietaria decidió llevarlo a otro centro veterinario. Con base en la anamnesis y los hallazgos anotados, se instaura tratamiento con antibiótico vía intramuscular (IM): Penicilina Benzatínica+Procaínica (Sancillín®) con dosis de 1 mL por cada 10 kg de peso vivo (0,3 mL intramuscular cada 72 horas); 5 mg de Prednisolona, dosis 0,2 mg/kg (½ tableta vía oral dos veces al día durante siete días y a continuación &#8211; de tableta diaria cada dos días durante siete días, se termina con ½ tableta diaria por otros siete días); Multivitamínico, Mirrapel®dosis de 1 mL por cada 4 kg de peso (1 mL vía oral cada 24 horas); Domeboro®polvo (un sobre disuelto en ¼ litro de agua, dos baños diarios). Se observó recuperación del epitelio hasta el cierre definitivo de la herida, tanto dorsal como ventral. El diagnóstico presuntivo fue el de la Necrólisis Epidérmica Tóxica, confirmado mediante histopatología.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The study was based on a mestizo canine of two and a half months old, weighing 3.5 kg, with loss of approximately 60% of skin at the thoracolumbar level and with the perianal area compromised. The dog had previously been treated for hemorrhagic gastroenteritis, with fluid therapy and intravenous antibiotics (IV), (Hartmann's solution, Metronidazole) plus Metoclopramide via subcutaneous (SC), during the first three days, showing an improvement. On the fourth day of treatment, blisters were formed on the skin at the dorsal level that later broke leaving a great solution of continuity. Prednisolone, Amoxicillin Trihydrate+Potassium Clavulanate (Uniclav®) were applied (doses not presented in the medical records submitted), without any improvement. The lesion progressed to affect the ventral area, reason why the owner decided to take the dog to another veterinary center. Based on the anamnesis and the recorded findings, the antibiotic treatment was established intramuscularly (IM): Penicillin Benzathine+Procaine (Sancillin®), dose of 1 mL per 10 kg of live weight mL (0.3 mL intramuscular every 72 hours); Prednisolone 5 mg, dose of 0.2 mg/kg (½ tablet orally twice a day for seven days), continuing with &#8211; tablet daily every other day for seven days, and ending with ½ tablet daily for other seven days; Multivitamin, Mirrapel®, dose of 1 mL per 4 kg of weight, administering 1 mL orally every 24 hours; Domeboro® powder, an envelope dissolved in ¼ liter of water, two daily baths, recovering the epithelium, until the final closure of the dorsal and ventral wound. The presumptive diagnosis was that of the Toxic Epidermal Necrolysis, confirmed by histopathology.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[canino]]></kwd>
<kwd lng="es"><![CDATA[dermatitis]]></kwd>
<kwd lng="es"><![CDATA[epitelio]]></kwd>
<kwd lng="es"><![CDATA[necrólisis epidérmica tóxica]]></kwd>
<kwd lng="en"><![CDATA[canine]]></kwd>
<kwd lng="en"><![CDATA[dermatitis]]></kwd>
<kwd lng="en"><![CDATA[epithelium]]></kwd>
<kwd lng="en"><![CDATA[toxic epidermal necrolysis]]></kwd>
</kwd-group>
</article-meta>
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