<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0375-0760</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Trop]]></abbrev-journal-title>
<issn>0375-0760</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0375-07602020000300005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Morbilidad por COVID-19: análisis de los aspectos epidemiológicos, clínicos y diagnósticos]]></article-title>
<article-title xml:lang="en"><![CDATA[COVID-19 morbidity: analysis of epidemiological, clinical and diagnostic aspects]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bandera Jiménez]]></surname>
<given-names><![CDATA[Digna de la C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morandeira Padrón]]></surname>
<given-names><![CDATA[Hilda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés García]]></surname>
<given-names><![CDATA[Luis E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Valdés]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sagaró del Campo]]></surname>
<given-names><![CDATA[Nelsa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palú Orozco]]></surname>
<given-names><![CDATA[Adrián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero Moya]]></surname>
<given-names><![CDATA[Lázaro I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Provincial de Higiene Epidemiologia y Microbiologia  ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Dirección Provincial de Salud  ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Santiago de Cuba  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Provincial Saturnino Lora  ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>72</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0375-07602020000300005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0375-07602020000300005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0375-07602020000300005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  En marzo de 2020 la OMS declaró pandemia a la COVID-19, enfermedad causada por el virus denominado SARS-CoV-2. Cuba, hasta el 9 de junio, reportó 2211 casos y 83 fallecidos; de estos 49 casos eran de Santiago de Cuba, con una letalidad de 6,12.  Objetivo:  Caracterizar la morbilidad por COVID-19 en Santiago de Cuba según aspectos epidemiológicos, clínicos y de diagnóstico seleccionados.  Métodos:  Estudio descriptivo transversal con los 49 pacientes confirmados en la provincia. Se efectuó la revisión de base de datos, estadísticas, historias epidemiológicas y clínicas. Se calcularon las tasas de incidencia, media aritmética y mediana, diferencia porcentual de tasas y prueba exacta de Fischer. Se utilizó el software EPIDAT con un nivel de confianza 95 % y significancia &#8804; 0,05 para determinar asociación estadística.  Resultados: La tasa de incidencia fue 4,7 por 1000 habitantes. Los municipios comprometidos fueron Santiago, Contramaestre y Palma Soriano. El mayor riesgo estuvo en el grupo de los mayores de 60 años, con síntomas frecuentes tos, fiebre y rinitis. El 26,53 % se encontró asintomático. Las principales comorbilidades asociadas fueron hipertensión arterial, trastornos neurológicos y respiratorios. Los procedimientos diagnósticos informaron RT-PCR positiva, LDH elevada, proteína C reactiva, hiperglucemia e infiltrado inflamatorio difuso pulmonar. Existió asociación estadística entre el periodo de evolución, 7 y más días desde el inicio de síntomas al ingreso, y el nivel de gravedad.  Conclusiones: El mayor riesgo de enfermar y fallecer se constató en edades más avanzadas de la vida. Los síntomas más frecuentes se comportaron de manera similar a lo descrito en la bibliografía consultada, así como los resultados de laboratorio. La demora en acudir a instituciones de salud y comorbilidades asociadas constituyeron un riesgo, de evolucionar hacia la gravedad y muerte.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  COVID-19, a disease caused by the virus named SARS-CoV-2, was declared pandemic by the WHO in March 2020. Until 9 June Cuba had reported 2 211 cases and 83 deaths. Forty-nine of these cases were from Santiago de Cuba, for a lethality of 6.12.  Objective:  Characterize COVID-19 morbidity in Santiago de Cuba based on the analysis of selected epidemiological, clinical and diagnostic aspects.  Method:  A descriptive cross-sectional study was conducted of the 49 patients confirmed in the province. A review was performed of databases, statistics, and clinical and epidemiological records. Estimation was made of incidence rates, arithmetic mean and median, percentage difference between the rates, and Fischer's exact test. Statistical association was determined with the software EPIDAT, using a confidence level of 95% and a significance level of &#8804; 0.05.  Results: The incidence rate was 4.7 per 1 000 inhabitants. The municipalities involved were Santiago, Contramaestre and Palma Soriano. The greatest risk lay in patients aged over 60 years, among whom coughing, fever and rhinitis were common symptoms. Of the patients studied, 26.53% were asymptomatic. The main associated comorbidities were hypertension and neurological and respiratory disorders. The results of the diagnostic procedures applied were positive RT-PCR, high LDH, C-reactive protein, hyperglycemia and diffuse inflammatory pulmonary infiltrate. A statistical association was found between the evolution period, 7 and more days from symptom onset to admission, and the degree of severity.  Conclusions: The highest risk of becoming ill and dying was found in the most advanced ages of life. The most common symptoms behaved in a manner similar to the one described in the bibliography consulted, and so did the laboratory results obtained. Delay in reporting to health institutions and associated comorbidities were risks for progression to severity and death.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[síntomas]]></kwd>
<kwd lng="es"><![CDATA[comorbilidad]]></kwd>
<kwd lng="es"><![CDATA[gravedad]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[symptoms, comorbidity]]></kwd>
<kwd lng="en"><![CDATA[severity]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="">
<collab>Ministerio de Sanidad</collab>
<source><![CDATA[Enfermedad por coronavirus, COVID-19. Actualización]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<collab>Cuba. Ministerio de Salud Pública</collab>
<source><![CDATA[Parte de Cierre del día 11 de mayo a las 12 de la noche]]></source>
<year>2020</year>
<publisher-name><![CDATA[Sitio Oficial de Gobierno del Ministerio de Salud Pública en Cuba]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berlin]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Gulick]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
</person-group>
<source><![CDATA[M.D Severe Covid-19]]></source>
<year></year>
<publisher-name><![CDATA[The New England Journal of Medicine]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zangrillo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beretta]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Scandroglio]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<source><![CDATA[Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy Crit Care Resusc]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodriguez-Morales]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis]]></article-title>
<source><![CDATA[Travel Med Infect Dis]]></source>
<year>2020</year>
<volume>34</volume>
<page-range>101623</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar Singh]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Misra]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers]]></article-title>
<source><![CDATA[Diabetes Metab Syndr]]></source>
<year>2020</year>
<volume>14</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>283-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guan]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis]]></article-title>
<source><![CDATA[Eur Respir J]]></source>
<year>2020</year>
<volume>55</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>2000547</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[International Journal of Infectious Diseases]]></source>
<year>2020</year>
<volume>94</volume>
<page-range>91-5</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="">
<collab>Sociedad Europea de Endocrinología</collab>
<source><![CDATA[COVID-19 y enfermedades endócrinas]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ching-Sung]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Yu-Jiun]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The outbreak of COVID-19: An overview]]></article-title>
<source><![CDATA[J Chin Med Assoc]]></source>
<year>2020</year>
<volume>83</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>217-20</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Irabien-Ortiz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Miocarditis fulminante por COVID-19]]></article-title>
<source><![CDATA[Rev Esp Cardiol]]></source>
<year>2020</year>
<volume>73</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>503-15</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Zhi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bi]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China]]></article-title>
<source><![CDATA[Clin Res Cardiol]]></source>
<year>2020</year>
<volume>109</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>531-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Freund]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[COVID-19: ¿Quiénes son los más afectados y por qué?]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trilla]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Un mundo, una salud: la epidemia por el nuevo coronavirus COVID-19]]></article-title>
<source><![CDATA[Med Clin (Barc)]]></source>
<year>2020</year>
<volume>154</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>175177</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Du]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China a retrospective cohort study]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2020</year>
<volume>395</volume>
<page-range>1054-62</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2020</year>
<volume>323</volume>
<page-range>1061-9</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="">
<collab>Centro Para el Control y la Prevención de Enfermedades</collab>
<source><![CDATA[Preguntas frecuentes sobre el coronavirus (COVID-19)]]></source>
<year>2020</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
